gene

CTSK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTSK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

0Analyses

6Outgoing

2Incoming

0Experiments

0Debates

Summary

Cysteine protease with collagenolytic activity implicated in bone disorders and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	CTSK
Full Name	Cathepsin K
Chromosome	1q21.3
Protein Type	Protease
Function	is a gene encoding a member of the papain family of cysteine proteases with remarkable collagenolytic activity.
Primary Expression	various tissues including the brain, where it participates in extracellular matrix remodeling, protein aggregate clearance, and neuroinflammatory proc
Amino Acids	329 aa
UniProt ID	[P43235](https://www.uniprot.org/uniprot/P43235)
Ensembl ID	ENSG00000136754
OMIM	601105
GeneCards	CTSK
Human Protein Atlas	CTSK
Propeptide	15-20 residues that maintain enzyme latency
Catalytic domain	~215 residues containing the active site
Unique N-terminal region	Conferring collagen-binding properties
Associated Diseases	Alzheimer's disease, Parkinson's disease
KG Connections	8 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CTSK — Cathepsin K

gene · 1476 words

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Pathway Diagram

graph TD
    CTSK["<b>CTSK</b>"]
    Cancer{"Cancer"}
    CTSK -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    CTSK -->|"expressed in"| Tumor
    MARCKS["MARCKS"]
    CTSK -->|"expressed in"| MARCKS
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    CTSK -->|"expressed in"| IMMUNE_INFILTRATION
    CANCER["CANCER"]
    CTSK -->|"expressed in"| CANCER
    APP["APP"]
    CTSK -->|"expressed in"| APP
    neurodegeneration["neurodegeneration"]
    CTSK -->|"implicated in"| neurodegeneration
    CD4["CD4"]
    CD4 -->|"expressed in"| CTSK
    THBS2["THBS2"]
    THBS2 -->|"expressed in"| CTSK
    style CTSK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
IMMUNE INFILTRATION	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
MARCKS	expressed_in	gene	0.60
APP	expressed_in	gene	0.60

Incoming (2)

Source	Relation	Type	Str
THBS2	expressed_in	gene	0.60
CD4	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity