gene

DIAPH3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DIAPH3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

4Outgoing

2Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	DIAPH3
Full Name	Diaphanous Formin 3 (mDia1, DRF1)
Aliases	Diaphanous Formin 3 (mDia1, DRF1)
Chromosome	13q21.2
Protein Family	Formin family
Function	is a member of the formin family of actin-nucleating proteins.
Subcellular Localization	Cytoplasm, Cytoskeleton, Membrane
Molecular Weight	146 kDa
Amino Acids	256 aa
Exons	29
Pathways	NF-κB
UniProt ID	Q9UQD0
GeneCards	DIAPH3
Human Protein Atlas	DIAPH3
Profilin	Binding (FH1 domain)
Associated Diseases	ANSD
KG Connections	6 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: DIAPH3 — AlphaFold Q9UQD0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DIAPH3["<b>DIAPH3</b>"]
    Als{"Als"}
    DIAPH3 -->|"therapeutic target"| Als
    Tumor{"Tumor"}
    DIAPH3 -->|"therapeutic target"| Tumor
    Glioblastoma{"Glioblastoma"}
    DIAPH3 -->|"therapeutic target"| Glioblastoma
    SYT1["SYT1"]
    DIAPH3 -->|"associated with"| SYT1
    neurodegeneration["neurodegeneration"]
    DIAPH3 -->|"implicated in"| neurodegeneration
    KCNH7["KCNH7"]
    KCNH7 -->|"associated with"| DIAPH3
    GBM["GBM"]
    GBM -->|"associated with"| DIAPH3
    style DIAPH3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (4)

Target	Relation	Type	Str
Als	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
SYT1	associated_with	gene	0.60

Incoming (2)

Source	Relation	Type	Str
KCNH7	associated_with	gene	0.60
GBM	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DIAPH3

Understanding Entity Pages

Wiki Pages (7)

diaph3

KCNH7 Gene

DIAPH3 Protein

Cochlear Hair Cells in Auditory Neuropathy Spectrum Disorder

INF2 (Inverted Formin 2)