gene

SYT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

189Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

SYT1 encodes synaptotagmin-1, the primary calcium sensor for fast synaptic vesicle exocytosis. Dysfunction contributes to synaptic failure in Alzheimer's disease, Parkinson's disease, and ALS.

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🧬 Gene Info

Gene Symbol	SYT1
Full Name	Synaptotagmin 1
Chromosome	12q21.2
Function	Synaptotagmin 1 is a presynaptic vesicular protein that functions as the calcium sensor for fast neurotransmitter release
Amino Acids	421 aa
Pathways	Apoptosis, Autophagy, autophagy pathway, oxidative stress response
UniProt ID	P21579
NCBI Gene ID	6856
Ensembl ID	ENSG00000130147
OMIM	185580
GeneCards	SYT1
Human Protein Atlas	SYT1
Disease	Mechanism
Alzheimer's Disease	Altered Ca²⁺ homeostasis affects synaptic vesicle cycling; SYT1 levels reduced in AD brains
Parkinson's Disease	Impaired synchronous release affects dopaminergic signaling
Associated Diseases	Alzheimer, neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	ACTB, JUN, ATG7, MAP2, SNAP25, CTSB
KG Connections	188 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SYT1 — AlphaFold P21579 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SYT1["SYT1"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    SYT1["SYT1"] -->|"activates"| Alzheimer["Alzheimer"]
    SYT1["SYT1"] -->|"activates"| Ms["Ms"]
    SYT1["SYT1"] -->|"activates"| Ischemia["Ischemia"]
    SYT1["SYT1"] -->|"activates"| Inflammation["Inflammation"]
    SYT1["SYT1"] -->|"activates"| Aging["Aging"]
    ACTB["ACTB"] -->|"activates"| SYT1["SYT1"]
    LAMP1["LAMP1"] -->|"associated"| SYT1["SYT1"]
    MTOR["MTOR"] -->|"associated"| SYT1["SYT1"]
    LC3["LC3"] -->|"associated"| SYT1["SYT1"]
    style SYT1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (104)

Target	Relation	Type	Str
Synaptic Dysfunction	biomarker_for	mechanism	0.85
Neurodegeneration	activates	disease	0.65
Alzheimer	activates	disease	0.65
Ms	activates	disease	0.65
Ischemia	activates	disease	0.65
Inflammation	activates	disease	0.65
Aging	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Stroke	activates	disease	0.65
LC3	associated_with	gene	0.60
ACTB	activates	gene	0.60
STAT3	regulates	gene	0.60
HMOX1	regulates	gene	0.60
TRPV1	regulates	gene	0.60
P2RY2	regulates	gene	0.60
FOXP3	regulates	gene	0.60
TPH2	regulates	gene	0.60
CCL3	regulates	gene	0.60
GFAP	associated_with	gene	0.60
NEFL	associated_with	gene	0.60
JUN	activates	gene	0.60
CTSB	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
TUBULIN	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
SNAP25	associated_with	gene	0.60
MAP2	associated_with	gene	0.60
TFEB	activates	entity	0.60
TUBB3	activates	entity	0.60
TUBULIN	activates	entity	0.60
MAP1LC3B	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
P62	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
ATG7	activates	gene	0.60
SYN1	associated_with	gene	0.60
Tubulin	associated_with	protein	0.60
BDNF	expressed_in	gene	0.60
SHANK2	expressed_in	gene	0.60
PRKACB	expressed_in	gene	0.60
PSD95	associated_with	gene	0.60
neurodegeneration	associated_with	disease	0.60

Incoming (85)

Source	Relation	Type	Str
ACTB	activates	gene	0.60
LAMP1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
LC3	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
ATG7	activates	gene	0.60
JUN	activates	gene	0.60
SQSTM1	associated_with	gene	0.60
MAP2	associated_with	gene	0.60
SYN1	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
SNAP25	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
P62	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
PANX1	regulates	gene	0.60
S100B	regulates	gene	0.60
RELB	regulates	gene	0.60
P2RY1	regulates	gene	0.60
CASP3	regulates	gene	0.60
SOCS3	regulates	gene	0.60
TRPA1	regulates	gene	0.60
CXCL2	regulates	gene	0.60
SNAP25	regulates	gene	0.60
P2RX7	regulates	gene	0.60
SYT2	regulates	gene	0.60
TNF	regulates	gene	0.60
SOD2	regulates	gene	0.60
NOS2	regulates	gene	0.60
P2RX3	regulates	gene	0.60
RELA	regulates	gene	0.60
SYP	regulates	gene	0.60
CHRNA7	regulates	gene	0.60
KCNH7	associated_with	gene	0.60
GBM	associated_with	gene	0.60
DIAPH3	associated_with	gene	0.60
TUBULIN	associated_with	gene	0.60
LAMP1	activates	gene	0.60
LC3	activates	gene	0.60
MTOR	activates	gene	0.60
RAGE	activates	gene	0.60
MAP1LC3B	activates	entity	0.60
MAP2	activates	entity	0.60
P62	activates	entity	0.60
SNAP25	activates	entity	0.60
SQSTM1	activates	entity	0.60
SYN1	activates	entity	0.60
PARKIN	associated_with	gene	0.60
PARKIN	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SYT1

Understanding Entity Pages

Summary

Wiki Pages (21)

SYT1 — Synaptotagmin 1

Synaptic Vesicle Trafficking in Parkinson's Disease

Allen Human Brain Atlas

PTBP2 - Polypyrimidine Tract Binding Protein 2

Synaptic Dysfunction Pathway

ALS Regional Onset and Spread: Network-Level Staging Model

Synaptic Vesicle Cycle

Synaptic Vesicle Trafficking

Synaptogenesis in Neurodegeneration

syt10

Activity-Dependent Synaptic Plasticity in Neurodegeneration

SYT9 Gene

synaptic-vesicle-cycling-neurodegeneration

SYT5 Gene

SYNAPTOGENIN — Synaptogyrin Family

Synaptic Vesicle Cycle in Neurodegeneration

Synaptic Vesicle Cycle

SYT6 (Synaptotagmin 6)

diaph3