Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DNA DOUBLE-STRAND BREAKS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | DNA DOUBLE-STRAND BREAKS |
Knowledge base pages for this entity
graph TD
DNA_DOUBLE_STRAND_BREAKS["DNA DOUBLE-STRAND BREAKS"]
DNA_DOUBLE_STRAND_BREAKS -->|"causes"| Genomic_Instability["Genomic Instability"]
DNA_DOUBLE_STRAND_BREAKS -->|"risk_factor_for"| Neurodegenerative_Disorders["Neurodegenerative Disorders"]
DNA_DOUBLE_STRAND_BREAKS -->|"activates"| cGAS_STING_pathway["cGAS-STING pathway"]
TOP1["TOP1"] -->|"causes"| DNA_DOUBLE_STRAND_BREAKS
R_Loops["R-Loops"] -->|"causes"| DNA_DOUBLE_STRAND_BREAKS
Transcription["Transcription"] -->|"mediates"| DNA_DOUBLE_STRAND_BREAKS
Transcription_Replication_Conf["Transcription-Replication Conflicts"] -->|"causes"| DNA_DOUBLE_STRAND_BREAKS
SNCA["SNCA"] -->|"causes"| DNA_DOUBLE_STRAND_BREAKS| Target | Relation | Type | Str |
|---|---|---|---|
| Genomic Instability | causes | phenotype | 0.90 |
| RAD51 | activates | gene | 0.90 |
| XRCC5 | activates | gene | 0.90 |
| Mitochondrial Apoptosis | activates | pathway | 0.90 |
| RAD51 | activates | gene | 0.90 |
| KU70/80 | activates | protein | 0.90 |
| transcriptional promoter assembly | associated_with | process | 0.88 |
| Neurodegenerative Disorders | contributes_to | disease | 0.85 |
| G2/M phase arrest | causes | phenotype | 0.85 |
| Neurodegenerative Disorders | risk_factor_for | disease | 0.75 |
| cGAS-STING pathway | activates | pathway | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TOP1 | causes | enzyme | 0.95 |
| TOP1 | mediates | enzyme | 0.95 |
| TOP1 | causes | enzyme | 0.95 |
| Boron Neutron Capture Therapy | causes | drug | 0.95 |
| Cas9 | causes | protein | 0.95 |
| BPA-BNCT | causes | drug | 0.95 |
| R-Loops | causes | structure | 0.94 |
| TOP1 | contributes_to | enzyme | 0.92 |
| Transcription | associated_with | process | 0.90 |
| Transcription | mediates | process | 0.90 |
| Transcription-Replication Conflicts | causes | process | 0.90 |
| Transcription-Replication Conflicts | causes | process | 0.90 |
| R-Loops | causes | mechanism | 0.90 |
| Transcription | causes | process | 0.90 |
| Single-Strand Breaks | causes | mechanism | 0.90 |
| homologous recombination | involved_in | pathway | 0.90 |
| R-loops | contributes_to | compound | 0.90 |
| Transcription | promotes | process | 0.90 |
| Single-Strand Breaks | contributes_to | process | 0.90 |
| dilncRNA | associated_with | process | 0.90 |
| base editing | suppresses | process | 0.90 |
| SNCA | causes | protein | 0.80 |
| PARP1 | involved_in | protein | 0.80 |
| Topoisomerase I | causes | protein | 0.80 |
| γ-H2A.X | biomarker_for | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-08 | 0 hypotheses
neurodegeneration | 2026-04-08 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||