pathway

cGAS-STING pathway

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about cGAS-STING pathway: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

277Connections

0Hypotheses

0Analyses

37Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	cGAS-STING pathway
Key Genes/Proteins	MTOR, substance P, pathogenic DNA, PINK1
Related Diseases	Amyotrophic Lateral Sclerosis, cardiac inflammation, tumor-derived DNA

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    cGAS_STING_pathway["cGAS-STING pathway"] -->|"promotes"| astrocyte_senescence["astrocyte senescence"]
    style astrocyte_senescence fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    cGAS_STING_pathway["cGAS-STING pathway"] -->|"causes"| cardiac_inflammation["cardiac inflammation"]
    style cardiac_inflammation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    cGAS_STING_pathway["cGAS-STING pathway"] -.->|"inhibits"| MTOR["MTOR"]
    style MTOR fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    cGAS_STING_pathway["cGAS-STING pathway"] -->|"promotes"| neurodegeneration["neurodegeneration"]
    style neurodegeneration fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    cGAS_STING_pathway["cGAS-STING pathway"] -->|"regulates"| neuroinflammation["neuroinflammation"]
    style neuroinflammation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    cGAS_STING_pathway["cGAS-STING pathway"] -->|"regulates"| tumor_derived_DNA["tumor-derived DNA"]
    style tumor_derived_DNA fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    cGAS_STING_pathway["cGAS-STING pathway"] -->|"regulates"| PRO_INFLAMMATORY_CYTOKINES["PRO-INFLAMMATORY CYTOKINES"]
    style PRO_INFLAMMATORY_CYTOKINES fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Mitophagy["Mitophagy"] -->|"interacts"| cGAS_STING_pathway["cGAS-STING pathway"]
    style Mitophagy fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    substance_P["substance P"] -.->|"inhibits"| cGAS_STING_pathway["cGAS-STING pathway"]
    style substance_P fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    pathogenic_DNA["pathogenic DNA"] -->|"activates"| cGAS_STING_pathway["cGAS-STING pathway"]
    style pathogenic_DNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PINK1["PINK1"] -.->|"inhibits"| cGAS_STING_pathway["cGAS-STING pathway"]
    style PINK1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    mitochondrial_DNA["mitochondrial DNA"] -->|"activates"| cGAS_STING_pathway["cGAS-STING pathway"]
    style mitochondrial_DNA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style cGAS_STING_pathway fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (136)

Target	Relation	Type	Str
neurodegeneration	implicated_in	process	1.00
Amyotrophic Lateral Sclerosis	associated_with	disease	0.95
astrocyte senescence	promotes	process	0.92
cardiac inflammation	causes	phenotype	0.90
MTOR	inhibits	protein	0.90
neurodegeneration	promotes	process	0.90
neuroinflammation	regulates	process	0.90
tumor-derived DNA	regulates	phenotype	0.90
neuroinflammation	mediates	process	0.90
PRO-INFLAMMATORY CYTOKINES	upregulates	protein	0.85
Neurodegenerative disorders	associated_with	disease	0.85
NLRP3 inflammasome activation	regulates	process	0.85
pulmonary fibrosis	promotes	disease	0.85
senescence	regulates	process	0.85
aging	associated_with	process	0.85
innate immune activation	activates	process	0.85
ferroptosis	regulates	phenotype	0.80
anti-tumor immunity	activates	pathway	0.80
antitumor immunity	activates	pathway	0.80
NLRP3	upstream_of	protein	0.80
adaptive immunity	activates	process	0.80
neuroinflammation	drives	process	0.80
Alzheimer's disease	exacerbates	disease	0.80
autoimmunity	causes	disease	0.70
cellular senescence	causes	phenotype	0.70
inflammatory diseases	causes	disease	0.70
cancer	associated_with	disease	0.70
Alzheimer's disease	associated_with	disease	0.70
microglia	activates	cell_type	0.70
interferon responses	activates	process	0.70
Parkinson's disease	associated_with	disease	0.70
proinflammatory response	activates	process	0.70
neuroinflammation	activates	disease	0.70
neurodegenerative disorders	associated_with	disease	0.70
dopaminergic neurodegeneration	activates	process	0.70
PD-L1	activates	concept	0.50
HER2	activates	concept	0.50

Incoming (141)

Source	Relation	Type	Str
Mitophagy	interacts_with	process	0.95
mtDNA efflux	activates	process	0.95
Cytosolic DNA buildup	activates	process	0.95
substance P	inhibits	protein	0.90
pathogenic DNA	activates	gene	0.90
PINK1	inhibits	gene	0.90
mitochondrial DNA	activates	protein	0.90
Damaged mitochondria	activates	organelle	0.90
mitochondrial DNA release	activates	process	0.90
TDP-43 pathology	associated_with	mechanism	0.90
Disturbed intracellular trafficking	activates	process	0.85
H-151	inhibits	drug	0.85
tumor-derived DNA	activates	gene	0.80
Effective Mitophagy	inhibits	process	0.80
FGF21	inhibits	protein	0.80
TSG	inhibits	drug	0.70
APOE3S/S	inhibits	gene	0.70
microglia	expresses_in	cell_type	0.70
VPS13C	regulates	protein	0.70
BCL2	activates	protein	0.70
dysfunctional mitophagy	activates	process	0.70
mitophagy	inhibits	process	0.70
damaged mitochondria	activates	cell_type	0.70
DNA double-strand breaks	activates	process	0.70
APOPTOSIS	triggers	process	0.70
ANXA1	activates	protein	0.50
CGAS	activates	protein	0.50
STING	activates	gene	0.50
TUMOR	activates	disease	0.50
Cgas-Sting	activates	pathway	0.50
Macrophage	activates	cell_type	0.50
Interferon Signaling	activates	pathway	0.50
IRF3	activates	gene	0.50
TBK1	activates	gene	0.50
Neuroinflammation	causes	process	0.50
Neurodegeneration	causes	disease	0.50
CGAS	causes	protein	0.50
STING	causes	gene	0.50
Neurodegenerative Diseases	causes	disease	0.50
Cgas-Sting	causes	pathway	0.50
disease	causes	disease	0.50
CGAS	associated_with	protein	0.50
STING	associated_with	gene	0.50
Cgas-Sting	associated_with	pathway	0.50
CGAS	interacts_with	protein	0.50
STING	interacts_with	gene	0.50
ALZHEIMER	interacts_with	gene	0.50
Alzheimer'S Disease	interacts_with	disease	0.50
HUNTINGTON	interacts_with	gene	0.50
MULTIPLE SCLEROSIS	interacts_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

cGAS-STING pathway

Understanding Entity Pages

Wiki Pages (20)

Novel Therapy Index

neuroinflammation

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Neuroinflammation-Mitochondria Crosstalk Pathway

DNA Damage Response Impairment Pathway

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Necroptotic Neurons

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Vestibular Function Testing in Corticobasal Syndrome

Lipid Metabolism Dysregulation in Neurodegeneration

PBKR03

Portable Driving Simulator for PD Assessment (NCT03969927)

cGAS-STING Signaling in Parkinson's Disease

Mitochondria in Neurodegeneration

Iron Homeostasis Dysregulation in Neurodegeneration

Neuroinflammation Microglia

nct07322003

Liver-Brain Neurodegeneration Axis