| Gene Symbol | DNA |
| Full Name | Dependent Protein Kinase Catalytic Subunit (DNA-PKcs) |
| Chromosome | 8q11.21 |
| Protein Family | PI3/PI4-related protein kinase family |
| Function | is an epigenetic modification that regulates gene expression without changing the DNA sequence. |
| Subcellular Localization | Nucleus (nuclear matrix), cytoplasm |
| Molecular Weight | 469 kDa (4,127 amino acids) |
| Pathways | AMPK signaling, Adaptive Immunity, Akt, Amyloid, Angiogenesis |
| UniProt ID | P78527 |
| GeneCards | DNA |
| Human Protein Atlas | DNA |
| Protein Name | DNA-PKcs (DNA-Dependent Protein Kinase Catalytic Subunit) |
| Gene | PRKDC |
| PDB Structures | 1JQT, 3KGV, 5W5R |
| Associated Diseases | AD, ALI, ALS, AMI, ARM, Addiction |
| Known Drugs/Compounds | rapamycin, metformin, ketamine, valproic acid, resveratrol |
| Interactions | MAPT, FAS, PEN2, APH1B, PSEN1, TARDBP |
| KG Connections | 5631 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |