Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DUSP9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DUSP9 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, implicated in. Associated with Cancer, Tumor. Connected to 10 entities in the SciDEX knowledge graph.
| Gene Symbol | DUSP9 |
| Aliases | MKP-4 |
| Chromosome | Xq28 |
| Protein Type | Phosphatase |
| Function | DUSP9 encodes MKP-4, a dual-specificity phosphatase belonging to the family of MAPK phosphatases (MKPs). |
| Primary Expression | placental and embryonic tissues |
| Amino Acids | 170 aa |
| Pathways | MAPK signaling, MAPK |
| UniProt ID | Q99956 |
| NCBI Gene ID | 1852 |
| Ensembl ID | ENSG00000138617 |
| OMIM | 300480 |
| GeneCards | DUSP9 |
| Human Protein Atlas | DUSP9 |
| Gene Name | Dual Specificity Phosphatase 9 |
| Associated Diseases | neurodegeneration |
| Interactions | FOXO3, KLF4, P38, HIF1, ERK |
| KG Connections | 9 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DUSP9["<b>DUSP9</b>"]
Cancer{"Cancer"}
DUSP9 -->|"regulates"| Cancer
Tumor{"Tumor"}
DUSP9 -->|"activates"| Tumor
FOXO3["FOXO3"]
DUSP9 -->|"activates"| FOXO3
HIF1["HIF1"]
DUSP9 -->|"activates"| HIF1
KLF4["KLF4"]
DUSP9 -->|"activates"| KLF4
CANCER["CANCER"]
DUSP9 -->|"regulates"| CANCER
P38["P38"]
DUSP9 -->|"activates"| P38
Mapk(["Mapk"])
DUSP9 -->|"activates"| Mapk
neurodegeneration["neurodegeneration"]
DUSP9 -->|"implicated in"| neurodegeneration
ERK["ERK"]
ERK -->|"activates"| DUSP9
style DUSP9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Source | Relation | Type | Str |
|---|---|---|---|
| ERK | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||