gene

DUSP9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DUSP9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections
0Hypotheses
0Analyses
8Outgoing
1Incoming

Summary

DUSP9 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, implicated in. Associated with Cancer, Tumor. Connected to 10 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolDUSP9
AliasesMKP-4
ChromosomeXq28
Protein TypePhosphatase
FunctionDUSP9 encodes MKP-4, a dual-specificity phosphatase belonging to the family of MAPK phosphatases (MKPs).
Primary Expressionplacental and embryonic tissues
Amino Acids170 aa
PathwaysMAPK signaling, MAPK
UniProt IDQ99956
NCBI Gene ID1852
Ensembl IDENSG00000138617
OMIM300480
GeneCardsDUSP9
Human Protein AtlasDUSP9
Gene NameDual Specificity Phosphatase 9
Associated Diseasesneurodegeneration
InteractionsFOXO3, KLF4, P38, HIF1, ERK
KG Connections9 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: DUSP9 — AlphaFold Q99956 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

DUSP9 Gene

gene · 926 words

MAP2K2 Gene

gene · 2515 words

dusp14

gene · 1452 words

DUSP8 Gene

gene · 966 words

Genes

index · 271 words

Pathway Diagram

graph TD
    DUSP9["<b>DUSP9</b>"]
    Cancer{"Cancer"}
    DUSP9 -->|"regulates"| Cancer
    Tumor{"Tumor"}
    DUSP9 -->|"activates"| Tumor
    FOXO3["FOXO3"]
    DUSP9 -->|"activates"| FOXO3
    HIF1["HIF1"]
    DUSP9 -->|"activates"| HIF1
    KLF4["KLF4"]
    DUSP9 -->|"activates"| KLF4
    CANCER["CANCER"]
    DUSP9 -->|"regulates"| CANCER
    P38["P38"]
    DUSP9 -->|"activates"| P38
    Mapk(["Mapk"])
    DUSP9 -->|"activates"| Mapk
    neurodegeneration["neurodegeneration"]
    DUSP9 -->|"implicated in"| neurodegeneration
    ERK["ERK"]
    ERK -->|"activates"| DUSP9
    style DUSP9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

TargetRelationTypeStr
Cancerregulatesdisease0.65
Tumoractivatesdisease0.65
FOXO3activatesgene0.60
KLF4activatesgene0.60
P38activatesgene0.60

Incoming (1)

SourceRelationTypeStr
ERKactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found