DUX4

Understanding Entity Pages

This page aggregates everything SciDEX knows about DUX4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    DUX4["DUX4"] -->|"causes"| Facioscapulohumeral_Muscular_D["Facioscapulohumeral Muscular Dystrophy"]
    style Facioscapulohumeral_Muscular_D fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    DUX4["DUX4"] -->|"expressed in"| Skeletal_Muscle["Skeletal Muscle"]
    style Skeletal_Muscle fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    DUX4["DUX4"] -->|"therapeutic target"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    DUX4["DUX4"] -.->|"inhibits"| MAPK["MAPK"]
    style MAPK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    DUX4["DUX4"] -.->|"inhibits"| P38["P38"]
    style P38 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    DUX4["DUX4"] -->|"expressed in"| AND["AND"]
    style AND fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    DUX4["DUX4"] -->|"therapeutic target"| App["App"]
    style App fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    p38__MAPK["p38alpha MAPK"] -->|"regulates"| DUX4["DUX4"]
    style p38__MAPK fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    MAPK_1["MAPK"] -->|"regulates"| DUX4["DUX4"]
    style MAPK_1 fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    P38_2["P38"] -.->|"inhibits"| DUX4["DUX4"]
    style P38_2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style DUX4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold