MAPK signaling

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    MAPK_signaling["MAPK signaling"] -->|"crosstalk with"| PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"]
    style PI3K_AKT_mTOR_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    MAPK_signaling["MAPK signaling"] -->|"crosstalk with"| NF_kB_signaling["NF-kB signaling"]
    style NF_kB_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    MAPK_signaling["MAPK signaling"] -->|"active in"| microglia["microglia"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    MAPK_signaling["MAPK signaling"] -->|"active in"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    MAPK_signaling["MAPK signaling"] -->|"crosstalk with"| unfolded_protein_response["unfolded protein response"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    MAPK_signaling["MAPK signaling"] -->|"active in"| astrocytes["astrocytes"]
    style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    MAPK_signaling["MAPK signaling"] -->|"mediates"| pyroptosis["pyroptosis"]
    style pyroptosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ERK["ERK"] -->|"participates in"| MAPK_signaling["MAPK signaling"]
    style ERK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    JNK["JNK"] -->|"participates in"| MAPK_signaling["MAPK signaling"]
    style JNK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PI3K["PI3K"] -->|"participates in"| MAPK_signaling["MAPK signaling"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    MAPK["MAPK"] -->|"participates in"| MAPK_signaling["MAPK signaling"]
    style MAPK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    neuroinflammation["neuroinflammation"] -->|"involves"| MAPK_signaling["MAPK signaling"]
    style neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    style MAPK_signaling fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold