Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Dolutegravir: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Endoplasmic Reticulum Stress | causes | process | 0.95 |
| Endoplasmic Reticulum Stress | associated_with | process | 0.95 |
| PERK | activates | protein | 0.92 |
| IRE1 | activates | protein | 0.92 |
| Blood-Brain Barrier Integrity | associated_with | phenotype | 0.90 |
| Blood-Brain Barrier Integrity | inhibits | phenotype | 0.90 |
| Brain Microvascular Endothelial Cells | targets | cell_type | 0.90 |
| Endoplasmic Reticulum Stress | induces | biological_process | 0.90 |
| Reactive Oxygen Species | upregulates | process | 0.88 |
| IL6 | upregulates | gene | 0.87 |
| CXCL1 | upregulates | gene | 0.87 |
| Neuropsychiatric Adverse Effects | causes | phenotype | 0.80 |
| eIF2α | activates | protein | 0.80 |
| Tight Junction Proteins | downregulates | protein_complex | 0.80 |
| Inflammatory Cytokines And Chemokines | increases | protein | 0.80 |
| Neuropsychiatric Adverse Effects | risk_factor_for | phenotype | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||