IRE1

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRE1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

IRE1 is a protein involved in neurodegeneration research. Key relationships include: activates, implicated in, expressed in. Associated with ALS. Connected to 23 entities in the SciDEX knowledge graph.

View on Wiki →

graph TD
    IRE1["<b>IRE1</b>"]
    ALS{"ALS"}
    IRE1 -->|"activates"| ALS
    IL6["IL6"]
    IRE1 -->|"activates"| IL6
    CXCL1["CXCL1"]
    IRE1 -->|"activates"| CXCL1
    Blood_Brain_Barrier(["Blood-Brain Barrier"])
    IRE1 -->|"activates"| Blood_Brain_Barrier
    Er_Stress(["Er Stress"])
    IRE1 -->|"activates"| Er_Stress
    ATF4["ATF4"]
    IRE1 -->|"activates"| ATF4
    PPP1R15A["PPP1R15A"]
    IRE1 -->|"activates"| PPP1R15A
    Endothelial_Cell["Endothelial Cell"]
    IRE1 -->|"expressed in"| Endothelial_Cell
    neurodegeneration["neurodegeneration"]
    IRE1 -->|"implicated in"| neurodegeneration
    Dolutegravir["Dolutegravir"]
    Dolutegravir -->|"activates"| IRE1
    XBP1["XBP1"]
    XBP1 -->|"activates"| IRE1
    ATF4 -->|"activates"| IRE1
    HSPA5["HSPA5"]
    HSPA5 -->|"activates"| IRE1
    CXCL2["CXCL2"]
    CXCL2 -->|"activates"| IRE1
    CLDN5["CLDN5"]
    CLDN5 -->|"activates"| IRE1
    IL23A["IL23A"]
    IL23A -->|"activates"| IRE1
    PERK["PERK"]
    PERK -->|"activates"| IRE1
    PPP1R15A -->|"activates"| IRE1
    DDIT3["DDIT3"]
    DDIT3 -->|"activates"| IRE1
    IL12B["IL12B"]
    IL12B -->|"activates"| IRE1
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"activates"| IRE1
    style IRE1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0