gene

PERK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PERK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

878Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

PERK is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, inhibits. Associated with AD, ALI, ALS. Connected to 269 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PERK
Protein Type	Kinase
Function	Stress sensing: Accumulation of unfolded proteins in the ER lumen
Subcellular Localization	the ER membrane. As one of the three major sensors of the unfolded protein response (UPR)
Molecular Weight	125 kDa
GeneCards	PERK
Human Protein Atlas	PERK
Interactor	Relationship
BiP/GRP78	Inhibitory binding partner
[eIF2α](/proteins/eif2a)	Phosphorylation substrate
ATF4	Downstream transcription factor
CHOP	ATF4 target
GADD34	Phosphatase regulator
Nrf2	PERK phosphorylates
FoxO1	PERK phosphorylates
Associated Diseases	AD, ALI, ALS, Aging, Alzheimer
Known Drugs/Compounds	Dolutegravir, SB202190, DTG, rapamycin
Interactions	MAP1LC3B, BECN1, RHOT1, STING1, LC3, MAPK8
KG Connections	878 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PERK["PERK"] -->|"interacts"| Alzheimer["Alzheimer"]
    PERK["PERK"] -->|"interacts"| ALS["ALS"]
    PERK["PERK"] -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    PERK["PERK"] -->|"interacts"| Dementia["Dementia"]
    PERK["PERK"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    PERK["PERK"] -->|"interacts"| Parkinson["Parkinson"]
    Dolutegravir["Dolutegravir"] -->|"activates"| PERK["PERK"]
    AGGF1["AGGF1"] -.->|"inhibits"| PERK["PERK"]
    BCL2L11["BCL2L11"] -->|"interacts"| PERK["PERK"]
    DNA["DNA"] -->|"interacts"| PERK["PERK"]
    style PERK fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (535)

Target	Relation	Type	Str
Endoplasmic Reticulum Stress	mediates	process	0.90
Endoplasmic Reticulum Stress	involved_in	process	0.85
eIF2A	phosphorylates	protein	0.85
ATF4	upregulates	protein	0.85
Tumor	activates	disease	0.85
Cancer	activates	disease	0.85
Er Stress	activates	pathway	0.80
Autophagy	activates	pathway	0.80
Tumor	inhibits	disease	0.75
Cancer	inhibits	disease	0.75
ATF4	activates	gene	0.70
NRF2	activates	gene	0.70
P62	activates	gene	0.70
BCL2	activates	gene	0.70
CANCER	inhibits	gene	0.70
CANCER	activates	gene	0.70
AUTOPHAGY	activates	gene	0.70
ADSL	activates	gene	0.70
Alzheimer's disease	activates	disease	0.70
autophagy pathway	participates_in	pathway	0.70
Alzheimer	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
ALS	activates	disease	0.65
Stroke	activates	disease	0.65
Ischemia	activates	disease	0.65
Als	activates	disease	0.65
Cardiac	activates	disease	0.65
Carcinoma	activates	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Infection	implicated_in	disease	0.65
Aging	implicated_in	disease	0.65
Ovarian Cancer	inhibits	disease	0.65
Lymphoma	inhibits	disease	0.65
Autoimmune	activates	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Senescence	associated_with	disease	0.65
Diabetes	inhibits	disease	0.65
Cardiac	inhibits	disease	0.65
Cardiovascular	activates	disease	0.65
Metabolic Syndrome	associated_with	disease	0.65
Ms	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Glioblastoma	activates	disease	0.65
Alzheimer	activates	disease	0.65

Incoming (343)

Source	Relation	Type	Str
SB202190	activates	drug	0.95
Dolutegravir	activates	drug	0.92
DTG	activates	drug	0.90
ATG2A-G433A	upregulates	variant	0.85
GRP78	interacts_with	protein	0.85
AGGF1	inhibits	gene	0.70
ROS	interacts_with	gene	0.70
BCL2L11	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
PARL	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
XBP1	activates	gene	0.60
ATF4	activates	gene	0.60
HSPA5	activates	gene	0.60
CXCL2	activates	gene	0.60
CLDN5	activates	gene	0.60
IL23A	activates	gene	0.60
P62	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PERK

Understanding Entity Pages

Summary

Wiki Pages (21)

PERK Protein

cbs-psp-daily-action-plan

Parkinson's Disease

Frontotemporal Dementia (FTD) Mechanistic Pathway

APOC4 — Apolipoprotein C-IV

psp-tauopathy

Niemann-Pick Disease Type C (NPC)

Copper Dyshomeostasis in Neurodegeneration

RPL30 — Ribosomal Protein L30 in Neurodegeneration

PEN2 Gene

RNA Metabolism Dysregulation in Alzheimer's Disease

TYNDASE — Tyndall

GBA1→GCase→Lysosome→PD Causal Chain

Synuclein Pathway in Parkinson's Disease

Metabolomic Alterations in PSP

tudca-udca-neurodegeneration

Transcriptional Regulation in Neurodegeneration

er-stress-neurodegeneration

Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD