gene

PERK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PERK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

878Connections

1Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

PERK is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, inhibits. Associated with AD, ALI, ALS. Connected to 269 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PERK
Protein Type	Kinase
Function	Stress sensing: Accumulation of unfolded proteins in the ER lumen
Subcellular Localization	the ER membrane. As one of the three major sensors of the unfolded protein response (UPR)
Molecular Weight	125 kDa
GeneCards	PERK
Human Protein Atlas	PERK
N-terminal luminal domain (1-576)	Senses misfolded proteins in the ER lumen; interacts with BiP/GRP78
Transmembrane domain (577-597)	Anchors PERK to ER membrane
Cytosolic kinase domain (666-1114)	Serine/threonine kinase activity; phosphorylates eIF2α
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	Dolutegravir, DTG, rapamycin, SB202190
Interactions	ABCA1, ABCA7, ABCD3, ACETYL-COA, ADSL, AGGF1
SciDEX Hypotheses	Cellular Stress Response Hijacking Prevention
KG Connections	878 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PERK Protein

protein · 957 words

→

EIF2AK3 Protein (PERK)

protein · 1678 words

→

Pathway Diagram

graph TD
    PERK["PERK"] -->|"interacts"| Alzheimer["Alzheimer"]
    PERK["PERK"] -->|"interacts"| ALS["ALS"]
    PERK["PERK"] -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    PERK["PERK"] -->|"interacts"| Dementia["Dementia"]
    PERK["PERK"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    PERK["PERK"] -->|"interacts"| Parkinson["Parkinson"]
    Dolutegravir["Dolutegravir"] -->|"activates"| PERK["PERK"]
    AGGF1["AGGF1"] -.->|"inhibits"| PERK["PERK"]
    BCL2L11["BCL2L11"] -->|"interacts"| PERK["PERK"]
    DNA["DNA"] -->|"interacts"| PERK["PERK"]
    style PERK fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (536)

Target	Relation	Type	Str
glymphatic_clearance	inhibits	mechanism	0.90
Endoplasmic Reticulum Stress	mediates	process	0.90
eIF2α phosphorylation	activates	mechanism	0.90
Tumor	activates	disease	0.85
Cancer	activates	disease	0.85
Endoplasmic Reticulum Stress	involved_in	process	0.85
eIF2A	phosphorylates	protein	0.85
ATF4	upregulates	protein	0.85
Er Stress	activates	pathway	0.80
Autophagy	activates	pathway	0.80
neuroinflammation	contributes_to	mechanism	0.75
Cancer	inhibits	disease	0.75
Tumor	inhibits	disease	0.75
autophagy pathway	participates_in	pathway	0.70
AUTOPHAGY	activates	gene	0.70
CANCER	activates	gene	0.70
CANCER	inhibits	gene	0.70
NRF2	activates	gene	0.70
ATF4	activates	gene	0.70
P62	activates	gene	0.70
BCL2	activates	gene	0.70
ADSL	activates	gene	0.70
Alzheimer's disease	activates	disease	0.70
Alzheimer	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Ovarian Cancer	inhibits	disease	0.65
ALS	activates	disease	0.65
Aging	implicated_in	disease	0.65
Alzheimer	inhibits	disease	0.65
Glioblastoma	activates	disease	0.65
Lymphoma	inhibits	disease	0.65
Dementia	interacts_with	disease	0.65
Ischemia	activates	disease	0.65
Stroke	activates	disease	0.65
Infection	implicated_in	disease	0.65
Ms	activates	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Cardiac	inhibits	disease	0.65
Autoimmune	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Cardiovascular	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Cardiovascular	activates	disease	0.65
Alzheimer	activates	disease	0.65
Metabolic Syndrome	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Cardiomyopathy	activates	disease	0.65

Incoming (342)

Source	Relation	Type	Str
PMID_31539650	sustained_activation_in_AD	publication	0.00
SB202190	activates	drug	0.95
Dolutegravir	activates	drug	0.92
DTG	activates	drug	0.90
ATG2A-G433A	upregulates	variant	0.85
GRP78	interacts_with	protein	0.85
AGGF1	inhibits	gene	0.70
ROS	interacts_with	gene	0.70
XBP1	activates	gene	0.60
CXCL2	activates	gene	0.60
CLDN5	activates	gene	0.60
HSPA5	activates	gene	0.60
P62	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
VDAC1	activates	gene	0.60
CAT	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
MCU	activates	gene	0.60
NOX4	interacts_with	gene	0.60
TBK1	activates	gene	0.60
LMNA	activates	entity	0.60
MAP1LC3B	activates	entity	0.60
MAPK8	activates	entity	0.60
MFN1	activates	entity	0.60
MIRO1	activates	entity	0.60
MUL1	activates	entity	0.60
NBR1	activates	entity	0.60
NDP52	activates	entity	0.60
NLRP3	activates	entity	0.60
OPTINEURIN	activates	entity	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Cellular Stress Response Hijacking Prevention	0.000	-	What determines the selectivity and effi

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning PERK in their description or question text

No additional research found