concept

REACTIVE OXYGEN SPECIES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about REACTIVE OXYGEN SPECIES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

525Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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💡 Concept Info

Name	REACTIVE OXYGEN SPECIES
Key Genes/Proteins	ABCD3, ACTIN, ALZHEIMER DISEASE, AMBRA1, AMPK, ATG
Related Diseases	ALS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Reactive Oxygen Species (ROS) Pathway

mechanism · 3211 words

→

Pathway Diagram

graph TD
    REACTIVE_OXYGEN_SPECIES["REACTIVE OXYGEN SPECIES"]
    REACTIVE_OXYGEN_SPECIES -->|"modulates"| DUBS["DUBS"]
    REACTIVE_OXYGEN_SPECIES -->|"modulates"| DUB["DUB"]
    REACTIVE_OXYGEN_SPECIES -->|"involved_in"| Neutrophil_Extracellular_Traps["Neutrophil Extracellular Traps"]
    REACTIVE_OXYGEN_SPECIES -.biomarker for.-> Hypertrophic_Scar["Hypertrophic Scar"]
    REACTIVE_OXYGEN_SPECIES -->|"modulates"| Catalytic_Cysteine["Catalytic Cysteine"]
    REACTIVE_OXYGEN_SPECIES -->|"contributes to"| amyloid_beta["amyloid beta"]
    REACTIVE_OXYGEN_SPECIES -->|"activates"| Separating_Microneedles["Separating Microneedles"]
    REACTIVE_OXYGEN_SPECIES -->|"contributes to"| Learning_and_Memory_Deficits["Learning and Memory Deficits"]
    REACTIVE_OXYGEN_SPECIES -->|"contributes to"| Protein_Accumulation["Protein Accumulation"]
    REACTIVE_OXYGEN_SPECIES -->|"activates"| mitochondrial_dysfunction["mitochondrial dysfunction"]
    HSPA1A["HSPA1A"] -->|"inhibits"| REACTIVE_OXYGEN_SPECIES
    Antioxidants["Antioxidants"] -->|"downregulates"| REACTIVE_OXYGEN_SPECIES
    PGC1A["PGC1A"] -->|"regulates"| REACTIVE_OXYGEN_SPECIES
    SLC7A11["SLC7A11"] -->|"downregulates"| REACTIVE_OXYGEN_SPECIES
    MT1["MT1"] -->|"modulates"| REACTIVE_OXYGEN_SPECIES
    MT2["MT2"] -->|"modulates"| REACTIVE_OXYGEN_SPECIES
    Dolutegravir["Dolutegravir"] -->|"upregulates"| REACTIVE_OXYGEN_SPECIES
    Lactic_Acid["Lactic Acid"] -->|"downregulates"| REACTIVE_OXYGEN_SPECIES
    GJA1_20k["GJA1-20k"] -->|"downregulates"| REACTIVE_OXYGEN_SPECIES
    Mitophagic_Flux_Inhibition["Mitophagic Flux Inhibition"] -->|"causes"| REACTIVE_OXYGEN_SPECIES

Outgoing (72)

Target	Relation	Type	Str
Neurodegeneration	causes	process	0.95
Parkinson Disease	contributes_to	disease	0.95
Alzheimer's Disease	contributes_to	disease	0.95
Neurodegeneration	contributes_to	process	0.90
PANoptosis	activates	process	0.90
DNM1L	phosphorylates	protein	0.90
AMPK-mTOR Pathway	activates	pathway	0.90
Acute Kidney Injury	associated_with	disease	0.90
GSDME	cleaves	protein	0.88
Oxidative Stress	causes	process	0.88
Amyloid Beta Aggregation	upregulates	process	0.85
Hypertrophic Scar	drives	disease	0.85
chondrocytes	associated_with	cell_type	0.85
ZBP1	activates	protein	0.85
TFEB Nuclear Translocation	mediates	mechanism	0.85
cytoskeletal proteins	degrades	protein	0.85
Mitochondrial Impairment	causes	phenotype	0.85
glioblastoma	treats	disease	0.85
P53	upstream_of	gene	0.80
Diabetes-Associated Cognitive Impairment	contributes_to	disease	0.80
amyloid beta	contributes_to	protein	0.80
Senescence	contributes_to	process	0.80
cognitive deficits	causes	phenotype	0.80
proinflammatory cytokines	increases	compound	0.80
Stimuli-responsive nanoplatforms	associated_with	compound	0.75
mitochondrial fragmentation	activates	process	0.70
mitochondrial dysfunction	activates	process	0.70
oxidative damage	activates	process	0.70
neuronal damage	activates	process	0.70
Mitochondrial dysfunction	activates	process	0.70
Oxidative stress	activates	process	0.70
BBB disruption	activates	process	0.70
neuroapoptosis	activates	process	0.70
brain damage	causes	process	0.70
Oxidative stress	causes	process	0.70
Brain cell death	activates	process	0.70
oxidative stress	activates	process	0.70
IKK complex	activates	protein	0.70
NUCLEUS	regulates	concept	0.50
CELL PROLIFERATION	associated_with	concept	0.50
Proteins	causes	protein	0.50
WNT SIGNALING	inhibits	concept	0.50
Proteins	activates	protein	0.50
NEUROFIBRILLARY TANGLES	activates	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
NUCLEUS	activates	concept	0.50
CHRONIC INFLAMMATION	interacts_with	concept	0.50
Cellular Senescence	activates	cell_type	0.50
α-SYNUCLEIN	causes	concept	0.50
FIBROBLASTS	interacts_with	concept	0.50

Incoming (453)

Source	Relation	Type	Str
Celastrol	promotes	compound	0.95
Ferroptosis	causes	process	0.95
DTG	upregulates	entity	0.95
TRPML1-TFEB pathway	inhibits	pathway	0.93
Type I photodynamic therapy	associated_with	process	0.92
Crocetin	suppresses	compound	0.90
selenium-containing compound	associated_with	compound	0.90
Rg1	associated_with	compound	0.90
DTG	upregulates	drug	0.90
stroke	causes	disease	0.90
FOXO1	regulates	gene	0.90
31745295	elevate	paper	0.90
34031600	triggers	paper	0.90
Icariin	inhibits	compound	0.90
34031600	generates	paper	0.90
curcumin	inhibits	drug	0.90
Mitochondrial Dysfunction	causes	process	0.90
PPARGC1A	regulates	gene	0.90
HSPA1A	suppresses	gene	0.90
GJA1-20k	suppresses	protein	0.90
Sevoflurane	causes	drug	0.90
Dolutegravir	upregulates	drug	0.88
Photodynamic Therapy	mediates	process	0.85
2,2,6,6-tetramethylpiperidine-1-oxyl	associated_with	compound	0.85
PPARGC1A	modulates	gene	0.85
SLC15A3	regulates	protein	0.85
CREBBP	regulates	gene	0.85
AKT	modulates	protein	0.85
Quercetier	downregulates	compound	0.85
Paeoniflorin	modulates	compound	0.85
Egcg	modulates	compound	0.80
SIRT3	regulates	gene	0.80
APOE	increases	gene	0.80
MICROGLIA	releases	cell_type	0.80
ischemia-reperfusion injury	increases	disease	0.80
Tryptamine	associated_with	compound	0.80
PRKAA1	regulates	gene	0.80
AMYLOID-BETA	associated_with	protein	0.80
5-fluorouracil	suppresses	drug	0.80
ERK	inhibits	protein	0.75
melatonin	inhibits	drug	0.70
ethanol	activates	drug	0.70
Ginsenoside Rb1	inhibits	drug	0.70
Tau protein	activates	protein	0.70
hyperphosphorylated tau	activates	protein	0.70
intraocular pressure	activates	process	0.70
amyloid beta	activates	protein	0.70
autophagy	regulates	process	0.70
Ischemia/reperfusion injury	activates	process	0.70
Amyloid β	activates	protein	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

neuroinflammation | 2026-04-08 | 5 hypotheses Top: 0.658

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While the study demonstrates both NF-κB pathway activation and increased C1qa ex

closed · Rounds: 4 · Score: 0.74 · 2026-04-21

Related Research

Hypotheses and analyses mentioning REACTIVE OXYGEN SPECIES in their description or question text

No additional research found