concept

EFTUD2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EFTUD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

0Analyses

24Outgoing

4Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	EFTUD2
Key Genes/Proteins	SCD1, GCH1, ATF4, AND
Related Diseases	Mandibulofacial Dysostosis With Microcephaly, Cerebellar Hypoplasia, Motor Dysfunction, Cerebellar Atrophy

Wiki Pages (1)

Knowledge base pages for this entity

SCD1 Gene

gene · 1200 words

→

Pathway Diagram

graph TD
    EFTUD2["EFTUD2"]
    EFTUD2 -->|"causes"| Mandibulofacial_Dysostosis_Wit["Mandibulofacial Dysostosis With Microcephaly"]
    EFTUD2 -->|"inhibits"| Ferroptosis["Ferroptosis"]
    EFTUD2 -->|"upregulates"| SCD1["SCD1"]
    EFTUD2 -->|"upregulates"| GCH1["GCH1"]
    EFTUD2 -->|"expressed in"| Purkinje_Cell["Purkinje Cell"]
    EFTUD2 -->|"activates"| AND["AND"]
    EFTUD2 -->|"activates"| ATF4["ATF4"]
    GCH1 -->|"activates"| EFTUD2
    SCD1 -->|"activates"| EFTUD2
    FERROPTOSIS["FERROPTOSIS"] -->|"activates"| EFTUD2
    ATF4 -->|"activates"| EFTUD2

Outgoing (24)

Target	Relation	Type	Str
Mandibulofacial Dysostosis With Microcephaly	causes	disease	0.95
Mandibulofacial Dysostosis With Microcephaly	associated_with	disease	0.95
Ferroptosis	suppresses	process	0.95
Ferroptosis	inhibits	process	0.90
Cerebellar Hypoplasia	associated_with	phenotype	0.90
SCD1	promotes	gene	0.90
GCH1	promotes	gene	0.90
SCD1	upregulates	gene	0.88
GCH1	upregulates	gene	0.88
Purkinje Cell	expressed_in	cell_type	0.85
ATF4	regulates	gene	0.85
Motor Dysfunction	associated_with	phenotype	0.85
Cerebellar Atrophy	contributes_to	phenotype	0.85
GCH1	activates	gene	0.60
AND	activates	gene	0.60
ATF4	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
P53	activates	gene	0.60
SCD1	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
Purkinje	causes	cell_type	0.60
ferroptosis	participates_in	pathway	0.60
cerebellum	expressed_in	brain_region	0.60
ferroptosis	activates	process	0.60

Incoming (4)

Source	Relation	Type	Str
GCH1	activates	gene	0.60
SCD1	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
ATF4	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found