Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PURKINJE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
graph TD
PURKINJE["PURKINJE"]
PURKINJE -->|"interacts"| STING["STING"]
PURKINJE -->|"expressed in"| Thalamus["Thalamus"]
PURKINJE -->|"expressed in"| Substantia_Nigra["Substantia Nigra"]
PURKINJE -->|"expressed in"| Hypothalamus["Hypothalamus"]
PURKINJE -->|"expressed in"| Cerebellum["Cerebellum"]
PURKINJE -->|"expressed in"| Hippocampus["Hippocampus"]
PURKINJE -->|"expressed in"| Cortex["Cortex"]
PURKINJE -->|"expressed in"| Striatum["Striatum"]
FERROPTOSIS["FERROPTOSIS"] -->|"causes"| PURKINJE
ATAXIA["ATAXIA"] -->|"sensitizes_to"| PURKINJE
CEREBELLUM["CEREBELLUM"] -->|"expressed in"| PURKINJE
PKC["PKC"] -->|"inhibits"| PURKINJE
VDR["VDR"] -->|"expressed in"| PURKINJE
ALZHEIMER["ALZHEIMER"] -.protects against.-> PURKINJE
GCH1["GCH1"] -->|"activates"| PURKINJE
SCD1["SCD1"] -->|"activates"| PURKINJE| Target | Relation | Type | Str |
|---|---|---|---|
| STING | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ATAXIA | sensitizes_to | disease | 0.65 |
| CEREBELLUM | expressed_in | brain_region | 0.60 |
| NEURON | expressed_in | cell_type | 0.60 |
| NEURONS | expressed_in | cell_type | 0.60 |
| GABAERGIC | associated_with | cell_type | 0.60 |
| NEURON | associated_with | cell_type | 0.60 |
| NEURONS | associated_with | cell_type | 0.60 |
| CEREBELLUM | activates | brain_region | 0.60 |
| C9ORF72 | causes | gene | 0.60 |
| CEREBELLUM | causes | brain_region | 0.60 |
| CEREBELLUM | co_discussed | entity | 0.50 |
| ATAXIA | co_discussed | disease | 0.40 |
| NEURON | co_discussed | cell_type | 0.40 |
| NEURONS | co_discussed | cell_type | 0.40 |
| CORTEX | co_discussed | brain_region | 0.40 |
| INTERNEURON | co_discussed | cell_type | 0.40 |
| INTERNEURONS | co_discussed | cell_type | 0.40 |
| C9ORF72 | co_discussed | gene | 0.40 |
| ASTROCYTE | co_discussed | cell_type | 0.40 |
| ASTROCYTES | co_discussed | cell_type | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||