concept

ADSL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ADSL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

32Connections

0Hypotheses

0Analyses

15Outgoing

17Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ADSL
Key Genes/Proteins	STING, PERK, AUTOPHAGY
Related Diseases	Tumor, Cancer, Carcinoma, Hepatocellular Carcinoma, Glioma
Related Pathways	Autophagy, de novo purine synthesis pathway

Wiki Pages (2)

Knowledge base pages for this entity

ADSS1 — Adenylosuccinate Synthetase 1

gene · 2373 words

→

ADSS2 — Adenylosuccinate Synthetase 2

gene · 1148 words

→

Pathway Diagram

graph TD
    ADSL["ADSL"]
    ADSL -->|"inhibits"| STING["STING"]
    ADSL -->|"activates"| Tumor["Tumor"]
    ADSL -->|"regulates"| fumarate["fumarate"]
    ADSL -->|"activates"| Autophagy["Autophagy"]
    ADSL -->|"contributes to"| Cancer["Cancer"]
    ADSL -->|"activates"| Carcinoma["Carcinoma"]
    ADSL -->|"activates"| Hepatocellular_Carcinoma["Hepatocellular Carcinoma"]
    ADSL -->|"activates"| Glioma["Glioma"]
    de_novo_purine_synthesis_pathw["de novo purine synthesis pathway"] -->|"activates"| ADSL
    PERK["PERK"] -->|"activates"| ADSL
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| ADSL
    BECLIN1["BECLIN1"] -->|"activates"| ADSL
    CANCER["CANCER"] -->|"contributes to"| ADSL
    BCL_2["BCL-2"] -->|"activates"| ADSL
    BECN1["BECN1"] -->|"activates"| ADSL
    EIF2AK3["EIF2AK3"] -->|"activates"| ADSL

Outgoing (15)

Target	Relation	Type	Str
STING	inhibits	protein	0.90
Tumor	activates	disease	0.85
fumarate	regulates	process	0.70
Autophagy	activates	pathway	0.70
Cancer	contributes_to	disease	0.65
Carcinoma	activates	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Cancer	associated_with	disease	0.65
Glioma	activates	disease	0.65
Als	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Als	associated_with	disease	0.65
Er Stress	activates	pathway	0.60
Tumor Microenvironment	activates	pathway	0.60
Stem Cell	activates	pathway	0.60

Incoming (17)

Source	Relation	Type	Str
de novo purine synthesis pathway	activates	pathway	0.70
PERK	activates	gene	0.70
AUTOPHAGY	activates	gene	0.70
BECLIN1	activates	gene	0.60
CANCER	contributes_to	gene	0.60
BCL-2	activates	gene	0.60
BECN1	activates	gene	0.60
EIF2AK3	activates	gene	0.60
BCL2	activates	gene	0.60
CANCER	associated_with	gene	0.60
PTEN	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
ERK2	associated_with	gene	0.60
AKT	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
ATP	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found