Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about galantamine: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Name | galantamine |
Knowledge base pages for this entity
flowchart TD
GALANTAMINE["GALANTAMINE"] -->|"activates"| MEMANTINE["MEMANTINE"]
GALANTAMINE["GALANTAMINE"] -.->|"inhibits"| AUTOPHAGY["AUTOPHAGY"]
GALANTAMINE["GALANTAMINE"] -->|"activates"| AUTOPHAGY["AUTOPHAGY"]
GALANTAMINE["GALANTAMINE"] -->|"associated with"| ALZHEIMER["ALZHEIMER"]
GALANTAMINE["GALANTAMINE"] -->|"associated with"| DONEPEZIL["DONEPEZIL"]
GALANTAMINE["GALANTAMINE"] -->|"associated with"| MEMANTINE["MEMANTINE"]
GALANTAMINE["GALANTAMINE"] -->|"associated with"| GLUTAMATE["GLUTAMATE"]
GALANTAMINE["GALANTAMINE"] -->|"associated with"| NEURONS["NEURONS"]
GALANTAMINE["GALANTAMINE"] -->|"associated with"| CHOLESTEROL["CHOLESTEROL"]
CORTEX["CORTEX"] -.->|"inhibits"| GALANTAMINE["GALANTAMINE"]
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated with"| GALANTAMINE["GALANTAMINE"]
EXCITOTOXICITY["EXCITOTOXICITY"] -->|"associated with"| GALANTAMINE["GALANTAMINE"]
RIVASTIGMINE["RIVASTIGMINE"] -->|"associated with"| GALANTAMINE["GALANTAMINE"]
DONEPEZIL["DONEPEZIL"] -->|"associated with"| GALANTAMINE["GALANTAMINE"]
CHOLESTEROL["CHOLESTEROL"] -->|"associated with"| GALANTAMINE["GALANTAMINE"]
CYP46A1["CYP46A1"] -->|"associated with"| GALANTAMINE["GALANTAMINE"]
GLUTAMATE_EXCITOTOXICITY["GLUTAMATE EXCITOTOXICITY"] -->|"associated with"| GALANTAMINE["GALANTAMINE"]
style GALANTAMINE fill:#6d3000,stroke:#333,color:#e0e0e0
style MEMANTINE fill:#6d3000,stroke:#333,color:#e0e0e0
style AUTOPHAGY fill:#5d2900,stroke:#333,color:#e0e0e0
style ALZHEIMER fill:#ef5350,stroke:#333,color:#e0e0e0
style DONEPEZIL fill:#6d3000,stroke:#333,color:#e0e0e0
style GLUTAMATE fill:#5d2900,stroke:#333,color:#e0e0e0
style NEURONS fill:#00695c,stroke:#333,color:#e0e0e0
style CHOLESTEROL fill:#5d2900,stroke:#333,color:#e0e0e0
style CORTEX fill:#4527a0,stroke:#333,color:#e0e0e0
style ALZHEIMER_S_DISEASE fill:#ef5350,stroke:#333,color:#e0e0e0
style EXCITOTOXICITY fill:#5d2900,stroke:#333,color:#e0e0e0
style RIVASTIGMINE fill:#6d3000,stroke:#333,color:#e0e0e0
style CYP46A1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style GLUTAMATE_EXCITOTOXICITY fill:#5d2900,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| HDAC3 | regulates | gene | 0.65 |
| MEMANTINE | activates | drug | 0.65 |
| AUTOPHAGY | inhibits | phenotype | 0.65 |
| AUTOPHAGY | activates | phenotype | 0.65 |
| ALZHEIMER | associated_with | disease | 0.50 |
| CYP46A1 | associated_with | gene | 0.45 |
| RIVASTIGMINE | associated_with | drug | 0.45 |
| HDAC3 | associated_with | gene | 0.45 |
| APP | associated_with | gene | 0.45 |
| DONEPEZIL | associated_with | drug | 0.45 |
| MEMANTINE | associated_with | drug | 0.45 |
| GLUTAMATE | associated_with | phenotype | 0.45 |
| NEURONS | associated_with | cell_type | 0.45 |
| CHOLESTEROL | associated_with | phenotype | 0.45 |
| AUTOPHAGY | associated_with | phenotype | 0.45 |
| CORTEX | associated_with | brain_region | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CORTEX | inhibits | brain_region | 0.65 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.50 |
| RIVASTIGMINE | associated_with | drug | 0.45 |
| CYP46A1 | associated_with | gene | 0.45 |
| GLUTAMATE EXCITOTOXICITY | associated_with | phenotype | 0.45 |
| EXCITOTOXICITY | associated_with | phenotype | 0.45 |
| DONEPEZIL | associated_with | drug | 0.45 |
| CHOLESTEROL | associated_with | phenotype | 0.45 |
| COGNITIVE DECLINE | associated_with | phenotype | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||