concept

CORTEX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CORTEX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1927Connections

7Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

CORTEX is a concept in neurodegeneration research. Key relationships include: co discussed, associated with, activates. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 105 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	CORTEX
Key Genes/Proteins	ABCA1, ABCA7, ABI3, ACHE, ACSL4, ADAM10
Related Diseases	ACETYLCHOLINE, AGING, ALS, ALZHEIMER, ALZHEIMER'S

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Temporal Association Cortex

cell · 2640 words

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Pathway Diagram

graph TD
    CORTEX["CORTEX"]
    BDNF["BDNF"] -->|"expressed in"| CORTEX
    MEF2C["MEF2C"] -->|"expressed in"| CORTEX
    HCN1["HCN1"] -->|"expressed in"| CORTEX
    EPILEPSY["EPILEPSY"] -->|"expressed in"| CORTEX
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| CORTEX
    AGING["AGING"] -->|"expressed in"| CORTEX
    TET2["TET2"] -->|"expressed in"| CORTEX
    DNA["DNA"] -->|"expressed in"| CORTEX
    GENES["GENES"] -->|"expressed in"| CORTEX
    CANCER["CANCER"] -->|"expressed in"| CORTEX

Outgoing (736)

Target	Relation	Type	Str
NEURON	interacts_with	cell_type	0.95
HIPPOCAMPUS	inhibits	brain_region	0.95
NEURON	activates	cell_type	0.95
HIPPOCAMPUS	regulates	brain_region	0.95
HIPPOCAMPUS	activates	brain_region	0.95
INTERNEURONS	expressed_in	cell_type	0.95
EPILEPSY	interacts_with	disease	0.95
STEM CELLS	activates	cell_type	0.95
STRIATUM	expressed_in	brain_region	0.95
PARVALBUMIN INTERNEURONS	expressed_in	entity	0.85
NEURON	associated_with	cell_type	0.80
CA1	causes	brain_region	0.70
SYNAPTIC LOSS	regulates	phenotype	0.70
ASTROCYTE	causes	cell_type	0.70
ALS	treats	disease	0.70
SYNAPTIC LOSS	causes	phenotype	0.70
TAU PHOSPHORYLATION	activates	phenotype	0.65
PINK1	activates	gene	0.65
TUMOR	activates	disease	0.65
MAPK	regulates	gene	0.65
TEMPORAL LOBE	activates	brain_region	0.65
PREFRONTAL CORTEX	impairs	brain_region	0.65
TAU	phosphorylates	gene	0.65
DLG4	degrades	gene	0.65
MEMORY LOSS	treats	phenotype	0.65
THALAMUS	expressed_in	brain_region	0.65
NEURODEGENERATION	regulates	process	0.65
GLUTAMATERGIC	activates	cell_type	0.65
PREFRONTAL CORTEX	transports	brain_region	0.65
PREFRONTAL CORTEX	contributes_to	brain_region	0.65
COGNITIVE DECLINE	causes	phenotype	0.65
GFAP	associated_with	gene	0.65
LYSOSOMAL DYSFUNCTION	activates	phenotype	0.65
NEURONS	produces	cell_type	0.65
ENTORHINAL	associated_with	brain_region	0.65
FRONTAL	regulates	brain_region	0.65
WHITE MATTER	reduces	brain_region	0.65
SPINAL CORD	accumulates_in	brain_region	0.65
GRAY MATTER	regulates	brain_region	0.65
NEURONS	reduces	cell_type	0.65
INTERNEURON	targets	cell_type	0.65
PERICYTE	interacts_with	cell_type	0.65
INTERNEURONS	targets	cell_type	0.65
ADAM10	activates	gene	0.65
PREFRONTAL	regulates	brain_region	0.65
MICROGLIAL ACTIVATION	inhibits	phenotype	0.65
PI3K	causes	gene	0.65
HIPPOCAMPUS	targets	brain_region	0.65
PINK1	treats	gene	0.65
ANXIETY	causes	disease	0.65

Incoming (1191)

Source	Relation	Type	Str
MICROGLIA	associated_with	cell_type	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
NF-KB	associated_with	protein	1.00
APP	associated_with	gene	1.00
AMYLOID	associated_with	protein	1.00
TAU	associated_with	protein	1.00
ASTROCYTES	associated_with	cell_type	1.00
TARDBP	associated_with	gene	1.00
TNF	associated_with	gene	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
ALS	associated_with	disease	0.98
schizophrenia	affects	disease	0.90
APP	expressed_in	gene	0.90
unfolded protein response	active_in	pathway	0.90
neurodegeneration	affects	disease	0.90
DNA	expressed_in	gene	0.90
Alzheimer's disease	affects	disease	0.90
aging	affects	disease	0.90
HCN1	expressed_in	entity	0.90
ALS	affects	disease	0.90
ALS	expressed_in	gene	0.90
BDNF	expressed_in	gene	0.90
BDNF	associated_with	gene	0.90
GFAP	expressed_in	gene	0.90
frontotemporal dementia	affects	disease	0.90
traumatic brain injury	affects	disease	0.90
RNA	expressed_in	gene	0.90
depression	affects	disease	0.90
epilepsy	affects	disease	0.90
neuroinflammation	affects	disease	0.90
SST	expressed_in	gene	0.90
DNA METHYLATION	expressed_in	entity	0.85
ASTROCYTES	expressed_in	cell_type	0.82
AMPK	associated_with	gene	0.82
autism	affects	disease	0.80
APOE	expressed_in	gene	0.80
anxiety	affects	disease	0.80
PI3K-AKT-mTOR signaling	active_in	pathway	0.80
dopamine receptor	expressed_in	receptor	0.80
CREB	expressed_in	gene	0.80
nicotinic receptor	expressed_in	receptor	0.80
TDP43	expressed_in	entity	0.80
RELN	expressed_in	entity	0.80
TNF	expressed_in	gene	0.80
AMPK	expressed_in	gene	0.80
AQP4	expressed_in	gene	0.80
HDAC3	expressed_in	gene	0.80
GABA	expressed_in	gene	0.80
MAPT	expressed_in	gene	0.80
FUS	expressed_in	gene	0.80

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.784	alzheimers	Circuit-level neural dynamics in neurode
Rab27A/B-mediated exosomal tau secretion from microglia driv	0.690	neurodegeneration	Which tau propagation mechanism predomin
Layer-Specific Excitatory Neuron Vulnerability in Temporal C	0.636	neurodegeneration	Methodology challenge: dataset 'Allen Br
Closed-loop transcranial focused ultrasound targeting motor	0.633	als	-
APOE4 Induces Region-Specific Microglial Senescence Driving	0.600	neuroinflammation	How do regional, age, and sex-dependent

Entorhinal Cortex (EC)-Hippocampus Closed-Loop Interface Res	0.535	alzheimers	Closed-loop optogenetic targeting PV int
Gait-Motor Cortex Plasticity Enhancement	0.000	-	Digital biomarkers and AI-driven early d

Mentioning Analyses (1)

Scientific analyses that reference this entity

Allen Mouse Brain Aging Atlas: cross-age gene expression analysis

neurodegeneration | 2026-04-23 | 8 hypotheses Top: 0.519

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How does gene expression change across age groups (young/middle/old) in hippocam

closed · Rounds: 4 · Score: 1.00 · 2026-04-24

Related Research

Hypotheses and analyses mentioning CORTEX in their description or question text

Entorhinal Cortex (EC)-Hippocampus Closed-Loop Interface Restores Layer-Specific

Score: 0.535 · alzheimers · 2026-04-28

Aβ accumulation in EC disrupts layer II stellate cell projections to dentate gyrus, fragmenting theta-phase precession a

Gait-Motor Cortex Plasticity Enhancement

Score: 0.000 · unknown disease · 2026-04-28

Transcranial stimulation protocols targeting motor cortex plasticity, combined with proprioceptive training, to strength