concept

CORTEX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CORTEX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1843Connections

1Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

CORTEX is a concept in neurodegeneration research. Key relationships include: co discussed, associated with, activates. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 105 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	CORTEX
Summary	Page for Cerebral Cortex
Key Genes/Proteins	NF-KB, TARDBP, AMYLOID
Related Diseases	ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, ALS, EPILEPSY
Linked Hypotheses	8 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Cerebral Cortex

brain · 775 words

→

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    CORTEX["CORTEX"]
    BDNF["BDNF"] -->|"expressed in"| CORTEX
    MEF2C["MEF2C"] -->|"expressed in"| CORTEX
    HCN1["HCN1"] -->|"expressed in"| CORTEX
    EPILEPSY["EPILEPSY"] -->|"expressed in"| CORTEX
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| CORTEX
    AGING["AGING"] -->|"expressed in"| CORTEX
    TET2["TET2"] -->|"expressed in"| CORTEX
    DNA["DNA"] -->|"expressed in"| CORTEX
    GENES["GENES"] -->|"expressed in"| CORTEX
    CANCER["CANCER"] -->|"expressed in"| CORTEX

Outgoing (669)

Target	Relation	Type	Str
STRIATUM	expressed_in	brain_region	0.95
NEURON	activates	cell_type	0.95
HIPPOCAMPUS	regulates	brain_region	0.95
STEM CELLS	activates	cell_type	0.95
HIPPOCAMPUS	activates	brain_region	0.95
EPILEPSY	interacts_with	disease	0.95
INTERNEURONS	expressed_in	cell_type	0.95
NEURON	interacts_with	cell_type	0.95
HIPPOCAMPUS	inhibits	brain_region	0.95
PARVALBUMIN INTERNEURONS	expressed_in	entity	0.85
NEURON	implicated_in	cell_type	0.80
SYNAPTIC LOSS	causes	phenotype	0.70
SYNAPTIC LOSS	regulates	phenotype	0.70
ALS	treats	disease	0.70
ASTROCYTE	causes	cell_type	0.70
CA1	causes	brain_region	0.70
FUS	regulates	gene	0.65
SOD1	regulates	gene	0.65
SPINAL CORD	expressed_in	brain_region	0.65
HIPPOCAMPUS	accumulates_in	brain_region	0.65
WHITE MATTER	reduces	brain_region	0.65
ENTORHINAL	associated_with	brain_region	0.65
FRONTAL	associated_with	brain_region	0.65
HIPPOCAMPUS	expressed_in	brain_region	0.65
HIPPOCAMPUS	contributes_to	brain_region	0.65
MOTOR NEURON	causes	cell_type	0.65
NEURON	reduces	cell_type	0.65
NEURONS	reduces	cell_type	0.65
PYRAMIDAL	reduces	cell_type	0.65
GFAP	sensitizes_to	gene	0.65
GABAERGIC	targets	cell_type	0.65
INTERNEURON	targets	cell_type	0.65
INTERNEURONS	targets	cell_type	0.65
FRONTAL	regulates	brain_region	0.65
PREFRONTAL	regulates	brain_region	0.65
SPINAL CORD	accumulates_in	brain_region	0.65
GLUTAMATERGIC	activates	cell_type	0.65
TUMOR	activates	disease	0.65
IPSC	activates	cell_type	0.65
GRAY MATTER	expressed_in	brain_region	0.65
MTOR	activates	gene	0.65
SCHIZOPHRENIA	regulates	disease	0.65
FRONTOTEMPORAL DEMENTIA	activates	disease	0.65
THALAMUS	expressed_in	brain_region	0.65
NEURODEGENERATION	regulates	process	0.65
EPILEPSY	expressed_in	disease	0.65
PREFRONTAL CORTEX	impairs	brain_region	0.65
TAU	phosphorylates	gene	0.65
PREFRONTAL CORTEX	contributes_to	brain_region	0.65
PREFRONTAL CORTEX	transports	brain_region	0.65

Incoming (1174)

Source	Relation	Type	Str
ASTROCYTES	associated_with	cell_type	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
MICROGLIA	associated_with	cell_type	1.00
NF-KB	associated_with	protein	1.00
TNF	associated_with	gene	1.00
TARDBP	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
AMYLOID	associated_with	protein	1.00
APP	associated_with	gene	1.00
TAU	associated_with	protein	1.00
ALS	associated_with	disease	0.98
BDNF	associated_with	gene	0.90
HCN1	expressed_in	entity	0.90
DNA METHYLATION	expressed_in	entity	0.85
AMPK	associated_with	gene	0.82
ASTROCYTES	expressed_in	cell_type	0.82
RELN	expressed_in	entity	0.80
TDP43	expressed_in	entity	0.80
AMYLOID-BETA	expressed_in	protein	0.80
AMYGDALA	regulates	brain_region	0.80
CEREBELLUM	expressed_in	brain_region	0.80
AMYGDALA	expressed_in	brain_region	0.80
IL-6	associated_with	gene	0.80
MTOR	associated_with	gene	0.80
BDNF	expressed_in	protein	0.79
APOPTOSIS	inhibits	process	0.74
APP	inhibits	gene	0.74
FUS	associated_with	gene	0.72
TRAUMATIC BRAIN INJURY	destabilizes	disease	0.70
ALS	stabilizes	disease	0.70
ALS	inhibits	disease	0.66
TNF	activates	gene	0.66
TAU	phosphorylates	protein	0.66
ALS	regulates	disease	0.66
APOE	activates	gene	0.66
APOE	associated_with	gene	0.66
C9ORF72	regulates	gene	0.65
CEREBELLUM	accumulates_in	brain_region	0.65
ALS	activates	disease	0.65
APP	treats	gene	0.65
APOE	interacts_with	gene	0.65
APOE3	interacts_with	gene	0.65
APOE4	associated_with	gene	0.65
TUMOR GROWTH	activates	phenotype	0.65
CD33	interacts_with	gene	0.65
NLRP3	degrades	gene	0.65
DRP1	activates	gene	0.65
DOPAMINE	causes	phenotype	0.65
HUNTINGTON'S DISEASE	treats	disease	0.65
NECROPTOSIS	activates	phenotype	0.65

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (12)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social [PMID:40320404]	Qi C, Sima W, Mao H, Hu E, Ge J et al.	Nat Commun	2025
Distinct dendritic integration strategies control dynamics of inhibition in the [PMID:40592329]	Morabito A, Zerlaut Y, Dhanasobhon D, Be	Neuron	2025
Cortical somatostatin long-range projection neurons and interneurons exhibit div [PMID:38086373]	Fisher J, Verhagen M, Long Z, Moissidis	Neuron	2024
Locus Coeruleus-Dorsolateral Septum Projections Modulate Depression-Like Behavio [PMID:38155473]	Zhang Q, Xue Y, Wei K, Wang H, Ma Y et a	Adv Sci (Weinh)	2024
Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981]	Almeida VN	Ageing Res Rev	2024
Somatostatin interneurons control the timing of developmental desynchronization [PMID:38599213]	Mòdol L, Moissidis M, Selten M, Oozeer F	Neuron	2024
De novo gene synthesis by an antiviral reverse transcriptase. [PMID:39116258]	Tang S, Conte V, Zhang DJ, Žedaveinytė R	Science	2024
Novel App knock-in mouse model shows key features of amyloid pathology and revea [PMID:35690868]	Xia D, Lianoglou S, Sandmann T, Calvert	Mol Neurodegener	2022
Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapi [PMID:33070149]	Fogaça MV, Wu M, Li C, Li XY, Picciotto	Mol Psychiatry	2021
Identification of Faecalibacterium prausnitzii strains for gut microbiome-based [PMID:34622235]	Ueda A, Shinkai S, Shiroma H, Taniguchi	Cell Rep Med	2021
Somatostatin, Olfaction, and Neurodegeneration. [PMID:32140092]	Saiz-Sanchez D, Ubeda-Bañon I, Flores-Cu	Front Neurosci	2020
Somatostatin replacement: a new strategy for treating diabetic retinopathy. [PMID:23745546]	Hernández C, Simó R, European Consortium	Curr Med Chem	2013

CORTEX

Understanding Entity Pages

Summary

Wiki Pages (21)

Cerebral Cortex

cbs-psp-daily-action-plan

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Pathway Diagram

Outgoing (669)

Incoming (1174)

Targeting Hypotheses (1)

Mentioning Analyses (3)

Entorhinal cortex layer II vulnerability in Alzheimer's disease

Selective vulnerability of entorhinal cortex layer II neurons in AD

Selective vulnerability of entorhinal cortex layer II neurons in AD

Related Papers (12)

CORTEX

Understanding Entity Pages

Summary

Wiki Pages (21)

Cerebral Cortex

cbs-psp-daily-action-plan

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

nimodipine-als

Neuroresilience Mechanisms and Evidence

NPM1 Gene

PI-2620 Tau PET in PSP

Neurons — Cell Type Hierarchy

Pathway Diagram

Outgoing (669)

Incoming (1174)

Targeting Hypotheses (1)

Mentioning Analyses (3)

Entorhinal cortex layer II vulnerability in Alzheimer's disease

Selective vulnerability of entorhinal cortex layer II neurons in AD

Selective vulnerability of entorhinal cortex layer II neurons in AD

Related Papers (12)