protein

CHOLESTEROL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHOLESTEROL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1791Connections

4Hypotheses

4Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	CHOLESTEROL
Associated Diseases	ALZHEIMER'S DISEASE, COGNITIVE DECLINE, DEPRESSION, GLUTAMATE, IMMUNE RESPONSE, LYSOSOMAL DYSFUNCTION
Known Drugs/Compounds	LUTEOLIN, RAPAMYCIN, DEXAMETHASONE
KG Connections	189 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CHOLESTEROL["CHOLESTEROL"] -->|"correlated with"| DEPRESSION["DEPRESSION"]
    style DEPRESSION fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    CHOLESTEROL["CHOLESTEROL"] -->|"triggers"| inflammasome_activation["inflammasome activation"]
    style inflammasome_activation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    CHOLESTEROL["CHOLESTEROL"] -->|"destabilizes"| LDLR["LDLR"]
    style LDLR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CHOLESTEROL["CHOLESTEROL"] -->|"activates"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    style PARKINSON_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    CHOLESTEROL["CHOLESTEROL"] -->|"interacts"| PROTEIN_AGGREGATION["PROTEIN AGGREGATION"]
    style PROTEIN_AGGREGATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    CHOLESTEROL["CHOLESTEROL"] -->|"regulates"| BACE1["BACE1"]
    style BACE1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CHOLESTEROL["CHOLESTEROL"] -->|"stabilizes"| SYNAPTIC_PLASTICITY["SYNAPTIC PLASTICITY"]
    style SYNAPTIC_PLASTICITY fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    APOE["APOE"] -->|"transports"| CHOLESTEROL["CHOLESTEROL"]
    style APOE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CYP46A1["CYP46A1"] -->|"metabolizes"| CHOLESTEROL["CHOLESTEROL"]
    style CYP46A1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    LRP1["LRP1"] -->|"transports"| CHOLESTEROL["CHOLESTEROL"]
    style LRP1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CA1["CA1"] -->|"regulates"| CHOLESTEROL["CHOLESTEROL"]
    style CA1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    DEXAMETHASONE["DEXAMETHASONE"] -->|"activates"| CHOLESTEROL["CHOLESTEROL"]
    style DEXAMETHASONE fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    style CHOLESTEROL fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (308)

Target	Relation	Type	Str
LDLR	destabilizes	gene	0.70
LDLR	causes	gene	0.70
PARKINSON'S DISEASE	activates	disease	0.70
PROTEIN AGGREGATION	interacts_with	phenotype	0.70
BACE1	regulates	gene	0.70
SYNAPTIC PLASTICITY	stabilizes	phenotype	0.70
MEMORY LOSS	inhibits	phenotype	0.70
MEMORY LOSS	activates	phenotype	0.70
CEREBELLUM	produces	brain_region	0.70
CEREBELLUM	destabilizes	brain_region	0.70
BDNF	destabilizes	gene	0.70
ASTROCYTE	produces	cell_type	0.70
DOPAMINE	inhibits	phenotype	0.70
APOE	protects_against	gene	0.70
APOE	produces	gene	0.70
DEMENTIA	interacts_with	disease	0.70
SYNAPTIC PLASTICITY	inhibits	phenotype	0.70
INSULIN RESISTANCE	treats	phenotype	0.65
NICOTINAMIDE	causes	drug	0.65
PYROPTOSIS	causes	phenotype	0.65
PYROPTOSIS	regulates	phenotype	0.65
BDNF	protects_against	gene	0.65
CEREBRAL CORTEX	interacts_with	brain_region	0.65
DEMYELINATION	treats	phenotype	0.65
NEURONS	causes	cell_type	0.65
NEURONS	treats	cell_type	0.65
NEURONS	produces	cell_type	0.65
OXIDATIVE STRESS	transports	phenotype	0.65
LDLR	treats	gene	0.65
MULTIPLE SCLEROSIS	causes	disease	0.65
LUTEOLIN	inhibits	drug	0.65
HMGCR	destabilizes	gene	0.65
WHITE MATTER	causes	brain_region	0.65
WHITE MATTER	activates	brain_region	0.65
LRRK2	activates	gene	0.65
LRRK2	regulates	gene	0.65
ALZHEIMER'S DISEASE	increases_risk	disease	0.65
CORTEX	interacts_with	brain_region	0.65
AUTOPHAGY	protects_against	phenotype	0.65
CYP46A1	encodes	gene	0.65
NLRP3 INFLAMMASOME	regulates	pathway	0.65
NEUROINFLAMMATION	exacerbates	phenotype	0.65
HEDGEHOG SIGNALING	inhibits	pathway	0.65
LYSOSOMAL DYSFUNCTION	regulates	phenotype	0.65
SENESCENCE	causes	phenotype	0.65
PROTEIN AGGREGATION	activates	phenotype	0.65
LYSOSOMAL DYSFUNCTION	causes	phenotype	0.65
NEURON	converts	cell_type	0.60
ASTROCYTE	converts	cell_type	0.60
APOE	converts	gene	0.60

Incoming (1483)

Source	Relation	Type	Str
CA1	regulates	brain_region	0.70
DEXAMETHASONE	activates	drug	0.70
ROS	treats	phenotype	0.70
LRP1	regulates	gene	0.70
MACROPHAGES	inhibits	cell_type	0.70
APOE	treats	gene	0.70
APOE	destabilizes	gene	0.70
APOE	causes	gene	0.70
FIBROBLASTS	interacts_with	cell_type	0.65
SIRT1	regulates	gene	0.65
MITOPHAGY	treats	phenotype	0.65
NF-KB SIGNALING	activates	pathway	0.65
NF-KB SIGNALING	regulates	pathway	0.65
NRF2 PATHWAY	interacts_with	pathway	0.65
NRF2	treats	gene	0.65
CYP46A1	produces	gene	0.65
RAPAMYCIN	treats	drug	0.65
RAPAMYCIN	inhibits	drug	0.65
EXOSOME	treats	organelle	0.65
PSEN1	produces	gene	0.65
AMYLOID	exacerbates	protein	0.65
AMYLOID	treats	protein	0.65
NIEMANN-PICK DISEASE	causes	disease	0.65
ASTROCYTES	treats	cell_type	0.65
FERROPTOSIS	protects_against	phenotype	0.65
STING	degrades	gene	0.65
MIGRAINE	regulates	disease	0.65
GLUTAMATE	activates	phenotype	0.65
BECN1	inhibits	gene	0.65
MICROGLIA	degrades	cell_type	0.65
MICROGLIA	encodes	cell_type	0.65
GLUTAMATE	targets	phenotype	0.65
ASTROCYTES	protects_against	cell_type	0.65
CYP46A1	regulates	gene	0.60
ABCG1	implicated_in	gene	0.60
CYP46A1	depleted_in	gene	0.60
NEURON	targets	cell_type	0.60
APOE	stabilizes	gene	0.60
ABCA1	targets	gene	0.60
APP	converts	gene	0.60
APP	treats	gene	0.60
CYP46A1	targets	gene	0.60
APOE	synergizes_with	gene	0.60
APP	implicated_in	gene	0.55
TDP-43	implicated_in	gene	0.55
LIPID RAFT	expressed_in	organelle	0.55
TFEB	implicated_in	gene	0.55
TFEB	participates_in	gene	0.55
ABCA1	participates_in	gene	0.55
APOE	participates_in	gene	0.55

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-Mediated Cholesterol Dysregulation in Microglial Senes	0.574	neurodegeneration	Gene expression changes in aging mouse b
TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulati	0.563	neuroimmunology	What is the temporal sequence of TREM2 s
Membrane Cholesterol Gradient Modulators	0.517	neurodegeneration	Lipid raft composition changes in synapt
Cholesterol-CRISPR Convergence Therapy for Neurodegeneration	0.484	neurodegeneration	CRISPR-based therapeutic approaches for

Mentioning Analyses (4)

Scientific analyses that reference this entity

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.505

APOE4-driven lipid metabolism dysregulation in astrocytes and its role in AD

neuroscience | 2026-04-04 | 0 hypotheses

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Lipid raft composition changes in synaptic neurodegeneration

neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.648

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
TREM2, microglia, and Alzheimer's disease. [PMID:33516818]	Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang	Mech Ageing Dev	2021	1
Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK [PMID:31693892]	Wang Y, An H, Liu T, Qin C, Sesaki H, Gu	Cell Rep	2019	1
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. [PMID:28802038]	Ulland TK, Song WM, Huang SC, Ulrich JD,	Cell	2017	1
The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkins [PMID:39964974]	Dai L, Wang J, Meng L, Zhang X, Xiao T,	PLoS biology	2025	0
HMGCR genetic variability in Parkinson's disease in a Spanish cohort: associatio [PMID:41037108]	Díaz-Belloso R, Martín-Bornez M, Macías-	Journal of neurology	2025	0
Development of Injectable Thermosensitive Nanocomposite Hydrogel for Ratiometric [PMID:38456789]	["Zhu J", "Wei R", "Hu G", "Wang H", "Wa	Small (Weinheim an der Bergstr	2024	0
RNA-Independent Regulatory Functions of lncRNA in Complex Disease. [PMID:39123456]	["Kafida M", "Karela M", "Giakountis A"]	Cancers	2024	0
25-Hydroxycholesterol attenuates tumor necrosis factor alpha-induced blood-brain [PMID:39181516]	Loiola RA, Nguyen C, Dib S, Saint-Pol J,	Biochimica et biophysica acta.	2024	0
Raccoon eyes. [PMID:35789012]	Ning J	Journal of paediatrics and chi	2023	0
Isolated Trapeziometacarpal Joint Dislocation With Five Years of Follow-up: A Ca [PMID:36891023]	["Missaoui Z", "Moussa M", "Boushnak M",	Cureus	2023	0
Exploring factors associated with preferences for human papillomavirus (HPV) sel [PMID:37234567]	["Xiong S", "Ghebre R", "Kulasingam S",	Preventive medicine reports	2023	0
Patient's Knowledge and Perception of Endodontics Treatment: An Observational St [PMID:37654321]	["Manasa N", "Naik K", "Singh M", "Moiz	Journal of pharmacy & bioallie	2023	0
Photosynthetic acclimation to changing environments. [PMID:36892145]	["Gjindali A", "Johnson G"]	Biochemical Society transactio	2023	0
Cholinergic neurodegeneration and cholesterol metabolism dysregulation by consti [PMID:37900943]	["Comaposada-Bar\u00f3 R", "Benito-Mart\	Frontiers in molecular neurosc	2023	0
Antiviral, immunomodulatory, and anticoagulant effects of quercetin and its deri [PMID:34567823]	["Manjunath S", "Thimmulappa R"]	Journal of pharmaceutical anal	2022	0
ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheim [PMID:35236834]	Zhao Y, Hu D, Wang R, Sun X, Ropelewski	Nature communications	2022	0
Comparative study of haemodynamic effects of intravenous ketamine-fentanyl and p [PMID:35102948]	["Okeyemi A", "Suleiman A", "Oyedepo O",	The Nigerian postgraduate medi	2022	0
Magnetic control of tokamak plasmas through deep reinforcement learning. [PMID:35173339]	Degrave J, Felici F, Buchli J, Neunert M	Nature	2022	0
Ambulatory Care Sensitive Conditions in Pediatrics: Time for a Reassessment. [PMID:34215678]	Lu S	Pediatrics	2021	0

CHOLESTEROL

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Parkinson's Disease

Therapeutics

CBS/PSP Treatment Rankings

Microglial Cells — Cell Type Hierarchy

coq10-neurodegeneration

TREM2 Mechanism Hub

Astrocyte Reactivity Mechanism

Growth Factor Therapies

Oligodendrocytes

APOC4 — Apolipoprotein C-IV

Prion vs Tau/Alpha-Synuclein Propagation: Mechanistic Comparison

TREM2 Microglial Signaling Pathway in Neurodegeneration

CNTN6 — Contactin 6

dendritic-spines

omega-3-fatty-acids-neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Vascular Cognitive Impairment (VCI)

CNTN4 — Contactin 4