Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GLIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | GLIA |
| Related Diseases | NEURODEGENERATIVE DISORDERS |
| Linked Hypotheses | 80 hypotheses |
Knowledge base pages for this entity
graph TD
GLIA["GLIA"]
GLIA -->|"involved_in"| Neuronal_Function["Neuronal Function"]
GLIA -->|"interacts"| inhibitory_neurons["inhibitory neurons"]
GLIA -->|"involved_in"| Alzheimer_s_Disease["Alzheimer's Disease"]
GLIA -->|"contributes to"| Motor_Neuron_Loss["Motor Neuron Loss"]
GLIA -->|"modulates"| Neurodegeneration["Neurodegeneration"]
GLIA -->|"mediates"| Ferroptosis["Ferroptosis"]
Motor_Neurons["Motor Neurons"] -->|"interacts"| GLIA
Sphingosine_1_Phosphate["Sphingosine-1-Phosphate"] -->|"expressed in"| GLIA
APOE4["APOE4"] -->|"expressed in"| GLIA
regulatory_modules["regulatory modules"] -->|"expressed in"| GLIA| Target | Relation | Type | Str |
|---|---|---|---|
| NEURONS | interacts_with | cell_type | 0.80 |
| NEURODEGENERATIVE DISORDERS | targets | disease | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Vlcfa | associated_with | compound | 0.90 |
| Motor Neurons | interacts_with | cell_type | 0.90 |
| Sphingosine-1-Phosphate | expressed_in | compound | 0.85 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.85 |
| PARKINSON'S DISEASE | associated_with | disease | 0.85 |
| APOE4 | expressed_in | protein | 0.80 |
| regulatory modules | expressed_in | pathway | 0.70 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neuroinflammation | 2026-04-15 | 1 hypotheses Top: 0.650
neuroimmunology | 2026-04-15 | 2 hypotheses Top: 0.674
neurodevelopment | 2026-04-15 | 1 hypotheses Top: 0.576
neurodegeneration | 2026-04-15 | 0 hypotheses
neuroinflammation | 2026-04-14 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214] | Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia | J Inflamm Res | 2022 | 1 |
| TREM2, microglia, and Alzheimer's disease. [PMID:33516818] | Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang | Mech Ageing Dev | 2021 | 1 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. [PMID:28802038] | Ulland TK, Song WM, Huang SC, Ulrich JD, | Cell | 2017 | 1 |
| The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663] | Krasemann S, Madore C, Cialic R, Baufeld | Immunity | 2017 | 1 |
| Modulating LRP1 Pathways in Alzheimer's Disease: Mechanistic Insights and Emergi [PMID:41772271] | Mushtaq T, Hameed H, Khan MA, Tariq U, H | Molecular neurobiology | 2026 | 0 |
| Macrophagic Sclerostin Loop2-ApoER2 Interaction Required by Sclerostin for Cardi [PMID:41276911] | Wang L, Tao X, Zhang N, Yang X, Jiang H | Adv Sci (Weinh) | 2026 | 0 |
| APOE Genotype Modulates the Relationship of Stroke With Dementia Risk: Associati [PMID:41404739] | Zhang CH, Huang LY, Feng YG, Tan CC, Tan | J Am Heart Assoc | 2026 | 0 |
| High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia: Evidence Fro [PMID:41406402] | Du Y, Borné Y, Samuelsson J, Glans I, Hu | Neurology | 2026 | 0 |
| Prime Editing of Alzheimer's Disease High-Risk APOE4 Allele by Brain-Directed Ad [PMID:41449667] | Günaydin C, Hackett NR, Wakim V, Sondhi | Hum Gene Ther | 2026 | 0 |
| The role of astrocytes in Alzheimer's disease: Pathophysiology, biomarkers, and [PMID:41527736] | Abedin MJ, Kastanenka KV | J Alzheimers Dis | 2026 | 0 |
| Endothelial TBK1 Deficiency Inhibits Endothelial-to-Mesenchymal Transition and A [PMID:41685426] | Pu Y, Dong P, He L, Huang J, Wu Y et al. | Circ Res | 2026 | 0 |
| Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differe [PMID:41692246] | Strickland MR, Wang Z, Golden LR, Wang H | J Lipid Res | 2026 | 0 |
| Protective mutations associated with APOE in Alzheimer's disease. [PMID:41703264] | Ma Y, Li Y, Wu G, Liu L, Tian M et al. | Mol Psychiatry | 2026 | 0 |
| HTRA1 and Brain Disorders: A Balancing Act Across Neurodegeneration and Repair. [PMID:41932381] | Hjæresen S, Gramkow ET, Zhang M, Svennin | Prog Neurobiol | 2026 | 0 |
| Trajectories of frailty, grip strength and gait speed preceding dementia: a nest [PMID:41936045] | Wu Z, Phyo AZZ, Cribb L, Vishwanath S, O | Age Ageing | 2026 | 0 |
| Amyloid-related imaging abnormalities in Japanese patients with Alzheimer's dise [PMID:41936348] | Shimasaki R, Kurihara M, Bannai T, Hatan | J Prev Alzheimers Dis | 2026 | 0 |
| Apolipoprotein E proteotyping as a valid alternative to genotyping in clinical p [PMID:41940854] | Alcalá Ramírez Del Puerto JM, Ortega-Mad | J Alzheimers Dis | 2026 | 0 |
| Opposing patterns of blood-brain barrier permeability and Alzheimer's disease bi [PMID:41942760] | Bernocchi F, Bonomi CG, Poli M, Di Donna | Neurological sciences : offici | 2026 | 0 |
| Structural MRI phenotyping in Alzheimer's disease: Comparison of visual rating s [PMID:41943971] | Aracki-Trenkic A, Živanović M, Milošević | Biomol Biomed | 2026 | 0 |