protein

GRM4PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRM4PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	GRM4PROTEIN
Full Name	Metabotropic Glutamate Receptor 4
Protein Type	Receptor
Function	is a Group III metabotropic glutamate receptor that serves primarily as a presynaptic autoreceptor, modulating glutamate release throughout the central nervous system.
Primary Expression	Brain (cerebellum, basal ganglia, hippocampus), peripheral tissues
Molecular Weight	102 kDa (912 aa)
Amino Acids	912 aa
UniProt ID	Q14833
GeneCards	GRM4PROTEIN
Human Protein Atlas	GRM4PROTEIN
Venus Fly Trap (VFT) Domain	Large extracellular glutamate-binding domain with low affinity for glutamate
Cysteine-Rich Domain (CRD)	Essential for receptor dimerization and signal transduction
7-TM Domain	Seven transmembrane helices forming the canonical GPCR bundle
Associated Diseases	Als, Bipolar, Depression, Ms, Prognosis
Known Drugs/Compounds	ADX88178, LSP2-9166
Interactions	CBX4, DAO, DISC1, G72, GRIN2B, GRM3
KG Connections	91 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GRM4PROTEIN — AlphaFold Q14833 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

mGluR4 Protein — Glutamate Metabotropic Receptor 4

protein · 947 words

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Pathway Diagram

graph TD
    GRM4PROTEIN["GRM4PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GRM4PROTEIN -->|"implicated_in"| neurodegeneration
    style GRM4PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GRM4PROTEIN in their description or question text

No additional research found