Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about G72: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
G72 is a concept in neurodegeneration research. Key relationships include: associated with. Associated with ALS, Als, BIPOLAR_DISORDER. Connected to 60 entities in the SciDEX knowledge graph.
| Name | G72 |
| Key Genes/Proteins | TRPM2, GENES, DRD1, BMAL1, GABRA5, GRM3 |
| Related Diseases | Bipolar Disorder, Depression, Bipolar, Schizophrenia, Als |
graph TD
G72["<b>G72</b>"]
G72 ---|"associated"| Depression["Depression"]
G72 ---|"associated"| Bipolar["Bipolar"]
G72 ---|"associated"| Schizophrenia["Schizophrenia"]
G72 ---|"associated"| Als["Als"]
G72 ---|"associated"| Ms["Ms"]
G72 ---|"associated"| ALS["ALS"]
HTTLPR["HTTLPR"] ---|"associated"| G72
MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] ---|"associated"| G72
BDNF["BDNF"] ---|"associated"| G72
PERIOD3["PERIOD3"] ---|"associated"| G72
HTR2A["HTR2A"] ---|"associated"| G72
GRM4["GRM4"] ---|"associated"| G72| Target | Relation | Type | Str |
|---|---|---|---|
| Bipolar Disorder | associated_with | disease | 0.90 |
| Depression | associated_with | disease | 0.65 |
| Bipolar | associated_with | disease | 0.65 |
| Schizophrenia | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| BIPOLAR_DISORDER | associated_with | disease | 0.64 |
| TRPM2 | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| DRD1 | associated_with | gene | 0.60 |
| BMAL1 | associated_with | gene | 0.60 |
| GABRA5 | associated_with | gene | 0.60 |
| GRM3 | associated_with | gene | 0.60 |
| DAO | associated_with | gene | 0.60 |
| NRG1 | associated_with | gene | 0.60 |
| GRIN2B | associated_with | gene | 0.60 |
| PDLIM5 | associated_with | gene | 0.60 |
| RGS4 | associated_with | gene | 0.60 |
| NCAM1 | associated_with | gene | 0.60 |
| DISC1 | associated_with | gene | 0.60 |
| POLG | associated_with | gene | 0.60 |
| MTDNA | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| FKBP5 | associated_with | gene | 0.60 |
| SYNGR1 | associated_with | gene | 0.60 |
| TPH2 | associated_with | gene | 0.60 |
| Circadian Rhythm | associated_with | pathway | 0.60 |
| HTTLPR | associated_with | gene | 0.60 |
| MITOCHONDRIAL DNA | associated_with | gene | 0.60 |
| GRM4 | associated_with | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| CIRCADIAN RHYTHM | associated_with | gene | 0.60 |
| DEPRESSION | associated_with | gene | 0.60 |
| PERIOD3 | associated_with | gene | 0.60 |
| HTR2A | associated_with | gene | 0.60 |
| Rb | associated_with | protein | 0.60 |
| App | associated_with | protein | 0.60 |
| GRIN2B | interacts_with | gene | 0.60 |
| GRM3 | interacts_with | gene | 0.60 |
| GRM4 | interacts_with | gene | 0.60 |
| NCAM1 | interacts_with | gene | 0.60 |
| NRG1 | interacts_with | gene | 0.60 |
| RGS4 | interacts_with | gene | 0.60 |
| SYNGR1 | interacts_with | gene | 0.60 |
| schizophrenia | interacts_with | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HTTLPR | associated_with | gene | 0.60 |
| MITOCHONDRIAL DNA | associated_with | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| PERIOD3 | associated_with | gene | 0.60 |
| HTR2A | associated_with | gene | 0.60 |
| GRM4 | associated_with | gene | 0.60 |
| BMAL1 | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| DAO | associated_with | gene | 0.60 |
| NCAM1 | associated_with | gene | 0.60 |
| RGS4 | associated_with | gene | 0.60 |
| DEPRESSION | associated_with | gene | 0.60 |
| GRIN2B | associated_with | gene | 0.60 |
| DRD1 | associated_with | gene | 0.60 |
| GABRA5 | associated_with | gene | 0.60 |
| FKBP5 | associated_with | gene | 0.60 |
| GRM3 | associated_with | gene | 0.60 |
| DISC1 | associated_with | gene | 0.60 |
| NRG1 | associated_with | gene | 0.60 |
| TRPM2 | associated_with | gene | 0.60 |
| POLG | associated_with | gene | 0.60 |
| SYNGR1 | associated_with | gene | 0.60 |
| PDLIM5 | associated_with | gene | 0.60 |
| MTDNA | associated_with | gene | 0.60 |
| CIRCADIAN RHYTHM | associated_with | gene | 0.60 |
| TPH2 | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| DAO | interacts_with | gene | 0.60 |
| DISC1 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||