| Gene Symbol | GRM4PROTEIN |
| Full Name | Metabotropic Glutamate Receptor 4 |
| Protein Type | Receptor |
| Function | is a Group III metabotropic glutamate receptor that serves primarily as a presynaptic autoreceptor, modulating glutamate release throughout the central nervous system. |
| Primary Expression | Brain (cerebellum, basal ganglia, hippocampus), peripheral tissues |
| Molecular Weight | 102 kDa (912 aa) |
| Amino Acids | 912 aa |
| UniProt ID | Q14833 |
| GeneCards | GRM4PROTEIN |
| Human Protein Atlas | GRM4PROTEIN |
| Venus Fly Trap (VFT) Domain | Large extracellular glutamate-binding domain with low affinity for glutamate |
| Cysteine-Rich Domain (CRD) | Essential for receptor dimerization and signal transduction |
| 7-TM Domain | Seven transmembrane helices forming the canonical GPCR bundle |
| Associated Diseases | Als, Bipolar, Depression, Ms, Prognosis |
| Known Drugs/Compounds | ADX88178, LSP2-9166 |
| Interactions | CBX4, DAO, DISC1, G72, GRIN2B, GRM3 |
| KG Connections | 91 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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