| Gene Symbol | GRM4 |
| Function | The GRM4 gene encodes mGluR4 (Glutamate Metabotropic Receptor 4), a member of the metabotropic glutamate receptor family. |
| Primary Expression | Brain (cerebellum, basal ganglia, hippocampus), peripheral tissues |
| Subcellular Localization | Presynaptic terminals, dendritic shafts, postsynaptic density |
| Molecular Weight | 102 kDa (912 aa) |
| Pathways | Circadian Rhythm |
| UniProt ID | Q14833 |
| Ensembl ID | ENSG00000168913 |
| GeneCards | GRM4 |
| Human Protein Atlas | GRM4 |
| Protein Name | Metabotropic Glutamate Receptor 4 |
| Structure | Class C GPCR: VFT, cysteine-rich, 7-TM domains |
| Approach | Mechanism |
| mGluR4 PAMs | Enhance receptor activity |
| mGluR4 Agonists | Direct activation |
| Associated Diseases | ALS, Bipolar, Depression, Ms, Prognosis |
| Known Drugs/Compounds | ADX88178, LSP2-9166 |
| Interactions | NPDC1, CBX4, SYNGR1, GRIN2B, NCAM1, NRG1 |
| KG Connections | 96 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |