Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GRM8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | GRM8 |
| Full Name | Glutamate Metabotropic Receptor 8 |
| Chromosome | 7q31.3 |
| Protein Type | Receptor |
| Function | The GRM8 gene encodes metabotropic glutamate receptor 8 (mGluR8), a class C G-protein coupled receptor that functions as a presynaptic autoreceptor inhibiting glutamate release. |
| Primary Expression | brain regions involved in anxiety and fear processing (amygdala, hippocampus) |
| UniProt ID | [Q9URF5](https://www.uniprot.org/uniprotkb/Q9URF5/entry) |
| Ensembl ID | ENSG00000128514 |
| GeneCards | GRM8 |
| Human Protein Atlas | GRM8 |
| Associated Diseases | Als |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GRM8["GRM8"]
Als{"Als"}
GRM8 -->|"associated_with"| Als
ESR1["ESR1"]
GRM8 -->|"regulates"| ESR1
PDE4B["PDE4B"]
GRM8 -->|"regulates"| PDE4B
FOXP2["FOXP2"]
GRM8 -->|"regulates"| FOXP2
CACNA1E["CACNA1E"]
GRM8 -->|"regulates"| CACNA1E
DCC["DCC"]
GRM8 -->|"regulates"| DCC
AXON["AXON"]
GRM8 -->|"regulates"| AXON
TRAF3["TRAF3"]
GRM8 -->|"regulates"| TRAF3
NCAM1["NCAM1"]
NCAM1 -->|"regulates"| GRM8
GRIA1["GRIA1"]
GRIA1 -->|"regulates"| GRM8
neurodegeneration["neurodegeneration"]
GRM8 -->|"implicated_in"| neurodegenerationHypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||