Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GRIA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GRIA1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, therapeutic target. Associated with Als, Alzheimer, Huntington. Connected to 38 entities in the SciDEX knowledge graph.
| Gene Symbol | GRIA1 |
| Full Name | Glutamate Ionotropic Receptor AMPA Type Subunit 1 |
| Chromosome | 5q31.1 |
| Function | The GRIA1 gene encodes the GluA1 protein subunit, one of four subunits (GluA1-4) that assemble to form AMPA-type ionotropic glutamate receptors. |
| Pathways | Epigenetic, Synaptic Plasticity |
| UniProt ID | P42262 |
| NCBI Gene ID | 2891 |
| Ensembl ID | ENSG00000155545 |
| OMIM | 138248 |
| GeneCards | GRIA1 |
| Human Protein Atlas | GRIA1 |
| Associated Diseases | Aging, Als, Alzheimer, Autism, Bipolar, Cancer |
| Interactions | ADRA1A, HRH1, GRIN1, HCRTR1, SNAP25, ACTG1 |
| KG Connections | 193 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GRIA1["<b>GRIA1</b>"]
Ms{"Ms"}
GRIA1 -->|"activates"| Ms
Als{"Als"}
GRIA1 -->|"activates"| Als
Parkinson{"Parkinson"}
GRIA1 -->|"therapeutic target"| Parkinson
Alzheimer{"Alzheimer"}
GRIA1 -->|"therapeutic target"| Alzheimer
Huntington{"Huntington"}
GRIA1 -->|"therapeutic target"| Huntington
GRIA1 -->|"therapeutic target"| Ms
ADRA1A["ADRA1A"]
GRIA1 -->|"activates"| ADRA1A
HRH1["HRH1"]
GRIA1 -->|"activates"| HRH1
GRIN1["GRIN1"]
GRIA1 -->|"activates"| GRIN1
HCRTR1["HCRTR1"]
GRIA1 -->|"activates"| HCRTR1
Epigenetic(["Epigenetic"])
GRIA1 -->|"activates"| Epigenetic
Dna_Methylation(["Dna Methylation"])
GRIA1 -->|"activates"| Dna_Methylation
DRD2["DRD2"]
DRD2 -->|"activates"| GRIA1
HRH3["HRH3"]
HRH3 -->|"activates"| GRIA1
HCRTR2["HCRTR2"]
HCRTR2 -->|"activates"| GRIA1
ADRA1B["ADRA1B"]
ADRA1B -->|"activates"| GRIA1
DRD1["DRD1"]
DRD1 -->|"activates"| GRIA1
CCT2["CCT2"]
CCT2 -->|"interacts with"| GRIA1
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"therapeutic target"| GRIA1
GFAP["GFAP"]
GFAP -->|"interacts with"| GRIA1
style GRIA1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Parkinson | therapeutic_target | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Huntington | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Prion | therapeutic_target | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Schizophrenia | associated_with | disease | 0.65 |
| Autism | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Dementia | regulates | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Bipolar | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| ADRA1A | activates | gene | 0.60 |
| HRH1 | activates | gene | 0.60 |
| GRIN1 | activates | gene | 0.60 |
| HCRTR1 | activates | gene | 0.60 |
| SNAP25 | interacts_with | gene | 0.60 |
| ACTG1 | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| GAPDH | interacts_with | gene | 0.60 |
| MAPK1 | interacts_with | gene | 0.60 |
| PSMA3 | interacts_with | gene | 0.60 |
| SOX2 | interacts_with | gene | 0.60 |
| YWHAZ | interacts_with | gene | 0.60 |
| HSP90AB1 | interacts_with | gene | 0.60 |
| ACTB | interacts_with | gene | 0.60 |
| CDC42 | interacts_with | gene | 0.60 |
| ATP5A1 | interacts_with | gene | 0.60 |
| SOD1 | interacts_with | gene | 0.60 |
| EGFR | interacts_with | gene | 0.60 |
| DRD1 | associated_with | gene | 0.60 |
| CACNA1B | associated_with | gene | 0.60 |
| GRM5 | associated_with | gene | 0.60 |
| HTR2A | associated_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| CACNA1H | associated_with | gene | 0.60 |
| HTR2C | associated_with | gene | 0.60 |
| DRD2 | associated_with | gene | 0.60 |
| REST | regulates | gene | 0.60 |
| HDAC4 | regulates | gene | 0.60 |
| SYN1 | associated_with | gene | 0.60 |
| GRM3 | associated_with | gene | 0.60 |
| GRM8 | regulates | gene | 0.60 |
| ESR1 | regulates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DRD2 | activates | gene | 0.60 |
| HRH3 | activates | gene | 0.60 |
| HCRTR2 | activates | gene | 0.60 |
| ADRA1B | activates | gene | 0.60 |
| DRD1 | activates | gene | 0.60 |
| CCT2 | interacts_with | gene | 0.60 |
| GFAP | interacts_with | gene | 0.60 |
| SOX2 | interacts_with | gene | 0.60 |
| SNAP25 | interacts_with | gene | 0.60 |
| SOD1 | interacts_with | gene | 0.60 |
| GAPDH | interacts_with | gene | 0.60 |
| CDC42 | interacts_with | gene | 0.60 |
| HSP90AB1 | interacts_with | gene | 0.60 |
| ACTB | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| EGFR | interacts_with | gene | 0.60 |
| PSMA3 | interacts_with | gene | 0.60 |
| ATP5A1 | interacts_with | gene | 0.60 |
| GABRB2 | associated_with | gene | 0.60 |
| SLC1A1 | associated_with | gene | 0.60 |
| SLC6A2 | associated_with | gene | 0.60 |
| GRIK4 | associated_with | gene | 0.60 |
| NCAM1 | regulates | gene | 0.60 |
| CACNA1B | associated_with | gene | 0.60 |
| HTR2A | associated_with | gene | 0.60 |
| DRD1 | associated_with | gene | 0.60 |
| GRM5 | associated_with | gene | 0.60 |
| CACNA1H | associated_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| HTR2C | associated_with | gene | 0.60 |
| DRD2 | associated_with | gene | 0.60 |
| HDAC4 | regulates | gene | 0.60 |
| SYN1 | associated_with | gene | 0.60 |
| CACNA1E | regulates | gene | 0.60 |
| DCC | regulates | gene | 0.60 |
| ESR1 | regulates | gene | 0.60 |
| FOXP2 | regulates | gene | 0.60 |
| ACTG1 | interacts_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.60 |
| PARKINSON | therapeutic_target | gene | 0.60 |
| HUNTINGTON | therapeutic_target | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| PSMD14 | interacts_with | gene | 0.60 |
| FN1 | interacts_with | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| GENES | interacts_with | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||