gene

GRIA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRIA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

193Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

GRIA1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, therapeutic target. Associated with Als, Alzheimer, Huntington. Connected to 38 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolGRIA1
Full NameGlutamate Ionotropic Receptor AMPA Type Subunit 1
Chromosome5q31.1
FunctionThe GRIA1 gene encodes the GluA1 protein subunit, one of four subunits (GluA1-4) that assemble to form AMPA-type ionotropic glutamate receptors.
PathwaysEpigenetic, Synaptic Plasticity
UniProt IDP42262
NCBI Gene ID2891
Ensembl IDENSG00000155545
OMIM138248
GeneCardsGRIA1
Human Protein AtlasGRIA1
Associated DiseasesAging, Als, Alzheimer, Autism, Bipolar, Cancer
InteractionsADRA1A, HRH1, GRIN1, HCRTR1, SNAP25, ACTG1
KG Connections193 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: GRIA1 — AlphaFold P42262 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

GRIA1 Gene

gene · 639 words

GRIA3 Gene

gene · 5408 words

Epigenetic Dysregulation in Neurodegeneration

mechanism · 4376 words

Retromer Dysfunction in Corticobasal Syndrome

mechanism · 3576 words

PTBP2 - Polypyrimidine Tract Binding Protein 2

gene · 3381 words

AMPA Receptor Neurons

cell · 3374 words

Pathway Diagram

graph TD
    GRIA1["<b>GRIA1</b>"]
    Ms{"Ms"}
    GRIA1 -->|"activates"| Ms
    Als{"Als"}
    GRIA1 -->|"activates"| Als
    Parkinson{"Parkinson"}
    GRIA1 -->|"therapeutic target"| Parkinson
    Alzheimer{"Alzheimer"}
    GRIA1 -->|"therapeutic target"| Alzheimer
    Huntington{"Huntington"}
    GRIA1 -->|"therapeutic target"| Huntington
    GRIA1 -->|"therapeutic target"| Ms
    ADRA1A["ADRA1A"]
    GRIA1 -->|"activates"| ADRA1A
    HRH1["HRH1"]
    GRIA1 -->|"activates"| HRH1
    GRIN1["GRIN1"]
    GRIA1 -->|"activates"| GRIN1
    HCRTR1["HCRTR1"]
    GRIA1 -->|"activates"| HCRTR1
    Epigenetic(["Epigenetic"])
    GRIA1 -->|"activates"| Epigenetic
    Dna_Methylation(["Dna Methylation"])
    GRIA1 -->|"activates"| Dna_Methylation
    DRD2["DRD2"]
    DRD2 -->|"activates"| GRIA1
    HRH3["HRH3"]
    HRH3 -->|"activates"| GRIA1
    HCRTR2["HCRTR2"]
    HCRTR2 -->|"activates"| GRIA1
    ADRA1B["ADRA1B"]
    ADRA1B -->|"activates"| GRIA1
    DRD1["DRD1"]
    DRD1 -->|"activates"| GRIA1
    CCT2["CCT2"]
    CCT2 -->|"interacts with"| GRIA1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"therapeutic target"| GRIA1
    GFAP["GFAP"]
    GFAP -->|"interacts with"| GRIA1
    style GRIA1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (115)

TargetRelationTypeStr
Msactivatesdisease0.65
Alsactivatesdisease0.65
Parkinsontherapeutic_targetdisease0.65
Alzheimertherapeutic_targetdisease0.65
Huntingtontherapeutic_targetdisease0.65

Incoming (78)

SourceRelationTypeStr
DRD2activatesgene0.60
HRH3activatesgene0.60
HCRTR2activatesgene0.60
ADRA1Bactivatesgene0.60
DRD1activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found