PDE4B

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDE4B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

PDE4B is a gene implicated in neurodegeneration research. Key relationships include: inhibits, activates, interacts with. Associated with Als, Alzheimer, Cardiac. Connected to 38 entities in the SciDEX knowledge graph.

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graph TD
    PDE4B["<b>PDE4B</b>"]
    Dementia{"Dementia"}
    PDE4B -->|"inhibits"| Dementia
    Alzheimer{"Alzheimer"}
    PDE4B -->|"inhibits"| Alzheimer
    Als{"Als"}
    PDE4B -->|"inhibits"| Als
    Ms{"Ms"}
    PDE4B -->|"interacts with"| Ms
    PDE4B -->|"therapeutic target"| Als
    Schizophrenia{"Schizophrenia"}
    PDE4B -->|"interacts with"| Schizophrenia
    Apoptosis(["Apoptosis"])
    PDE4B -->|"inhibits"| Apoptosis
    APP_PS1["APP/PS1"]
    PDE4B -->|"inhibits"| APP_PS1
    APP["APP"]
    PDE4B -->|"inhibits"| APP
    BDNF["BDNF"]
    PDE4B -->|"inhibits"| BDNF
    APOPTOSIS["APOPTOSIS"]
    PDE4B -->|"inhibits"| APOPTOSIS
    BCL_2["BCL-2"]
    PDE4B -->|"inhibits"| BCL_2
    APP -->|"inhibits"| PDE4B
    BCL_2 -->|"inhibits"| PDE4B
    BDNF -->|"inhibits"| PDE4B
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"inhibits"| PDE4B
    NDEL1["NDEL1"]
    NDEL1 -->|"therapeutic target"| PDE4B
    DISC1["DISC1"]
    DISC1 -->|"interacts with"| PDE4B
    style PDE4B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0