protein

CACNA1E

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CACNA1E: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

74Connections

0Hypotheses

0Analyses

39Outgoing

35Incoming

0Experiments

Summary

Page for CACNA1E Protein (Cav2.3 R-type Calcium Channel)

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🔬 Protein Info

Gene Symbol	CACNA1E
Full Name	Calcium Voltage-Gated Channel Subunit Alpha1 E
Aliases	Cav2.3 R-type Calcium Channel
Chromosome	1q25.1
Function	The CACNA1E gene encodes the α1E subunit that forms the pore of the R-type voltage-gated calcium channel (CaV2.3).
Primary Expression	hippocampal neurons, cerebellar granule cells, and various cortical regions - Dendritic localization: Primarily located on de
Molecular Weight	250 kDa
Amino Acids	233 aa
UniProt ID	Q15878
NCBI Gene ID	777
Ensembl ID	ENSG00000198004
GeneCards	CACNA1E
Human Protein Atlas	CACNA1E
Disease	Association Type
[Alzheimer's Disease](/diseases/alzheimers-disease)	Risk Modulator
Associated Diseases	Als
Interactions	CACNA1F, CACNA1I, CACNA2D1, CACNA2D2, CACNA1H, CACNA1G
KG Connections	74 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CACNA1E — AlphaFold Q15878 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CACNA1E["<b>CACNA1E</b>"]
    CACNA2D3["CACNA2D3"]
    CACNA1E -->|"associated with"| CACNA2D3
    PRKAB1["PRKAB1"]
    CACNA1E -->|"therapeutic target"| PRKAB1
    CNR1["CNR1"]
    CACNA1E -->|"therapeutic target"| CNR1
    DIABETIC_RETINOPATHY["DIABETIC RETINOPATHY"]
    CACNA1E -->|"therapeutic target"| DIABETIC_RETINOPATHY
    EPAS1["EPAS1"]
    CACNA1E -->|"associated with"| EPAS1
    CTSD["CTSD"]
    CACNA1E -->|"associated with"| CTSD
    CEBPA["CEBPA"]
    CACNA1E -->|"associated with"| CEBPA
    neurodegeneration["neurodegeneration"]
    CACNA1E -->|"implicated in"| neurodegeneration
    EPAS1 -->|"associated with"| CACNA1E
    CACNG6["CACNG6"]
    CACNG6 -->|"associated with"| CACNA1E
    BIN1["BIN1"]
    BIN1 -->|"associated with"| CACNA1E
    CHRNA2["CHRNA2"]
    CHRNA2 -->|"therapeutic target"| CACNA1E
    CEBPA -->|"associated with"| CACNA1E
    GENES["GENES"]
    GENES -->|"protects against"| CACNA1E
    CNR1 -->|"therapeutic target"| CACNA1E
    CTSD -->|"associated with"| CACNA1E
    NME1["NME1"]
    NME1 -->|"therapeutic target"| CACNA1E
    PRKAB1 -->|"therapeutic target"| CACNA1E
    style CACNA1E fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (39)

Target	Relation	Type	Str
Als	associated_with	disease	0.65
CACNA2D3	associated_with	gene	0.60
PRKAB1	therapeutic_target	gene	0.60
CNR1	therapeutic_target	gene	0.60
EPAS1	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
CEBPA	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
CACNA1D	associated_with	gene	0.60
CACNA1G	associated_with	gene	0.60
DCC	regulates	gene	0.60
TRAF3	regulates	gene	0.60
CACNA2D1	associated_with	gene	0.60
GAIN	contributes_to	gene	0.60
CACNA1F	associated_with	gene	0.60
CACNA1A	associated_with	gene	0.60
CCS	contributes_to	gene	0.60
CACNA2D2	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
CACNA1I	associated_with	gene	0.60
CACNA1F	interacts_with	gene	0.60
CACNA1I	interacts_with	gene	0.60
CACNA2D1	interacts_with	gene	0.60
CACNA2D2	interacts_with	gene	0.60
ESR1	regulates	gene	0.60
FOXP2	regulates	gene	0.60
GRIA1	regulates	gene	0.60
GRM8	regulates	gene	0.60
NCAM1	regulates	gene	0.60
PDE4B	regulates	gene	0.60
DIABETIC RETINOPATHY	therapeutic_target	gene	0.60
AXON	regulates	gene	0.60
AND	associated_with	gene	0.60
CACNA1H	interacts_with	protein	0.50
CACNA1G	interacts_with	protein	0.50
CACNA1A	interacts_with	gene	0.50
CACNA1C	interacts_with	gene	0.50
CACNA1G	co_expressed_with	protein	0.50
CACNA1H	co_expressed_with	protein	0.50

Incoming (35)

Source	Relation	Type	Str
EPAS1	associated_with	gene	0.60
CACNG6	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
CHRNA2	therapeutic_target	gene	0.60
CEBPA	associated_with	gene	0.60
CNR1	therapeutic_target	gene	0.60
CTSD	associated_with	gene	0.60
NME1	therapeutic_target	gene	0.60
PRKAB1	therapeutic_target	gene	0.60
CACNA1A	associated_with	gene	0.60
CCS	contributes_to	gene	0.60
CACNA1C	associated_with	gene	0.60
CACNA2D2	associated_with	gene	0.60
CACNA1F	associated_with	gene	0.60
CACNA1I	associated_with	gene	0.60
CACNA2D1	associated_with	gene	0.60
NCAM1	regulates	gene	0.60
GRIA1	regulates	gene	0.60
GRM8	regulates	gene	0.60
ESR1	regulates	gene	0.60
PDE4B	regulates	gene	0.60
FOXP2	regulates	gene	0.60
CACNA1G	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
CACNA1A	interacts_with	gene	0.60
CACNA1C	interacts_with	gene	0.60
GENES	protects_against	gene	0.60
GENES	associated_with	gene	0.60
CACNA1D	interacts_with	gene	0.50
CACNA2D2	interacts_with	gene	0.50
CACNA1I	interacts_with	gene	0.50
CACNA2D1	interacts_with	gene	0.50
CACNA1C	co_expressed_with	gene	0.50
CACNA1D	co_expressed_with	gene	0.50
cacna1f	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CACNA1E

Understanding Entity Pages

Summary

Wiki Pages (21)

CACNA1E Gene

calcium-dysregulation-comparison

L-type Calcium Channel

CACNA2D2 Gene

voltage-gated-calcium-channel-neurons

PRKAB1 — Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1

sca6

Calcium Channel Dysfunction in Parkinson's Disease

CACNG1 Gene - Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 1

RBFOX1 Protein (A2BP1)

Calcium Channel Dysfunction in Neurodegeneration

SCN4A Gene

CACNG6 (TARP γ8)

CACNA1E Protein (Cav2.3 R-type Calcium Channel)

GRM8 Gene

CACNA1D Gene

CACNA2D1 Gene - Calcium Channel Voltage-Dependent Subunit Alpha2 Delta 1

CHRNA2 — Cholinergic Receptor Nicotinic Alpha 2

CACNA1S Protein - Cav1.1 Calcium Channel

CACNA2D3 Gene