protein

HNRPU

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HNRPU: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

20Connections

0Hypotheses

0Analyses

14Outgoing

6Incoming

0Experiments

0Debates

Summary

Page for HNRPU — HNRPU Protein

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🔬 Protein Info

Gene Symbol	HNRPU
Full Name	Heterogeneous Nuclear Ribonucleoprotein U
Chromosome	1q44
Function	HNRNP U (hnRNP U) encodes a nuclear matrix protein with multiple functional domains including an acidic region, glycine-rich domains, and an RNA-binding domain.
Subcellular Localization	the nucleus, where it associates with nuclear matrix structures and chromatin, though emerging evidence suggests cytopla
Molecular Weight	120 kDa
Amino Acids	806 aa
UniProt ID	[Q00839](https://www.uniprot.org/uniprot/Q00839)
Ensembl ID	ENSG00000197181
OMIM	604365
GeneCards	HNRPU
Human Protein Atlas	HNRPU
Associated Diseases	ALS
Interactions	Actin, AND, DNA, HNRNPA2B1, NUCLEOLIN, Proteins
KG Connections	20 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HNRPU — Heterogeneous Nuclear Ribonucleoprotein U

gene · 681 words

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HNRPU — HNRPU Protein

protein · 797 words

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Pathway Diagram

flowchart TD
    N0["HNRPU"]
    N1["Als"]
    N0 -->|"inhibits"| N1
    N2["ALS"]
    N0 -->|"inhibits"| N2
    N3["SRPK1"]
    N0 -->|"inhibits"| N3
    N4["NUCLEOLIN"]
    N0 -->|"inhibits"| N4
    N5["RNA"]
    N0 -->|"inhibits"| N5
    N6["AND"]
    N0 -->|"inhibits"| N6
    N7["TAF15"]
    N0 -->|"inhibits"| N7
    N8["Dna Repair"]
    N0 -->|"inhibits"| N8
    N9["HNRNPA2B1"]
    N0 -->|"inhibits"| N9
    N10["DNA"]
    N0 -->|"inhibits"| N10
    N11["Actin"]
    N0 -->|"inhibits"| N11
    N7 -->|"inhibits"| N0
    N10 -->|"inhibits"| N0
    N9 -->|"inhibits"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 pathway
    class N9 gene
    class N10 gene
    class N11 protein

Outgoing (14)

Target	Relation	Type	Str
ALS	inhibits	disease	0.65
Als	inhibits	disease	0.65
TAF15	inhibits	gene	0.60
AND	inhibits	gene	0.60
Dna Repair	inhibits	pathway	0.60
RNA	inhibits	gene	0.60
HNRNPA2B1	inhibits	gene	0.60
DNA	inhibits	gene	0.60
Actin	inhibits	protein	0.60
ALS	associated_with	disease	0.60
SRPK1	inhibits	gene	0.60
NUCLEOLIN	inhibits	gene	0.60
TAF15	co_expressed_with	protein	0.50
Proteins	inhibits	protein	0.50

Incoming (6)

Source	Relation	Type	Str
TAF15	inhibits	gene	0.60
HNRNPA2B1	inhibits	gene	0.60
NUCLEOLIN	inhibits	gene	0.60
DNA	inhibits	gene	0.60
RNA	inhibits	gene	0.60
HNRNPA2B1	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity