gene 681 words KG: HNRPU 2026-03-12
kind:genesection:genesstate:published
Contents

HNRPU — Heterogeneous Nuclear Ribonucleoprotein U

🧬 Gene Info
Gene SymbolHNRPU
Full NameHeterogeneous Nuclear Ribonucleoprotein U
Chromosome1q44
FunctionHNRNP U (hnRNP U) encodes a nuclear matrix protein with multiple functional domains including an acidic region, glycine-rich domains, and an RNA-binding domain.
Subcellular Localizationthe nucleus, where it associates with nuclear matrix structures and chromatin, though emerging evidence suggests cytopla
Molecular Weight120 kDa
Amino Acids806 aa
UniProt ID[Q00839](https://www.uniprot.org/uniprot/Q00839)
Ensembl IDENSG00000197181
OMIM604365
GeneCardsHNRPU
Human Protein AtlasHNRPU
Associated DiseasesALS
InteractionsSRPK1, NUCLEOLIN, TAF15, HNRNPA2B1, RNA, AND
KG Connections20 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (2)

Axonal RNA Transport Reconstitution
Score: 0.45
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (17)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40
s:** - Temporal analysis showing mitochondrial defects prece
falsification · proposed · Score: 0.40
Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.40
s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40

See Also (8)

Nucleolin Protein
protein · KG edge: inhibits
Proteins
index · KG edge: inhibits
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: inhibits
TAF15 Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

HNRPU inhibits SRPK1
HNRPU inhibits NUCLEOLIN
HNRPU inhibits TAF15
HNRPU inhibits HNRNPA2B1
HNRPU inhibits Als
HNRPU inhibits RNA
HNRPU inhibits AND
HNRPU inhibits ALS
HNRPU inhibits Dna Repair
HNRPU inhibits DNA