gene 681 words KG: HNRPU
Contents

HNRPU — Heterogeneous Nuclear Ribonucleoprotein U

🧬 Gene Info
Gene SymbolHNRPU
Full NameHeterogeneous Nuclear Ribonucleoprotein U
Chromosome1q44
FunctionHNRNP U (hnRNP U) encodes a nuclear matrix protein with multiple functional domains including an acidic region, glycine-rich domains, and an RNA-binding domain.
Subcellular Localizationthe nucleus, where it associates with nuclear matrix structures and chromatin, though emerging evidence suggests cytopla
Molecular Weight120 kDa
Amino Acids806 aa
UniProt ID[Q00839](https://www.uniprot.org/uniprot/Q00839)
Ensembl IDENSG00000197181
OMIM604365
GeneCardsHNRPU
Human Protein AtlasHNRPU
Associated DiseasesALS
InteractionsActin, DNA, HNRNPA2B1, NUCLEOLIN, Proteins, RNA
KG Connections19 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (2)

Axonal RNA Transport Reconstitution
Score: 0.70
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (17)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
s:** - Temporal analysis showing mitochondrial defects prece
falsification · proposed · Score: 0.40
Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.40
s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40

See Also (8)

Neurodegeneration
disease · KG edge: implicated_in
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: inhibits
Heterogeneous Nuclear Ribonucleoprotein A2/B1 (HNRNPA2B
gene · KG edge: inhibits
TAF15 Gene
gene · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: inhibits

Knowledge Graph (12 edges)

TAF15 inhibits HNRPU
HNRNPA2B1 inhibits HNRPU
HNRPU inhibits SRPK1
HNRPU inhibits NUCLEOLIN
HNRPU inhibits TAF15
HNRPU inhibits HNRNPA2B1
NUCLEOLIN inhibits HNRPU
HNRNPA2B1 co_expressed_with HNRPU
HNRPU co_expressed_with TAF15
DNA inhibits HNRPU

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