protein

TAF15

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAF15: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

126Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

Summary

Page for TAF15 Protein

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🔬 Protein Info

Gene Symbol	TAF15
Full Name	TATA-Binding Protein Associated Factor 15
Chromosome	16p11.2
Protein Type	Transcription Factor
Function	TAF15 contains an N-terminal transcriptional activation domain and a C-terminal RNA recognition motif (RRM) domain, allowing it to function in both transcription and RNA processing.
Primary Expression	most tissues with highest expression in:
Molecular Weight	65 kDa
UniProt ID	Q92804
NCBI Gene ID	8148
Ensembl ID	ENSG00000172660
OMIM	601679
GeneCards	TAF15
Human Protein Atlas	TAF15
Associated Diseases	Als, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety, Dementia, Huntington
Interactions	FUS, HNRNPA2B1, HNRPU, NUCLEOLIN, HNRNPA1, DNA
KG Connections	126 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TAF15["<b>TAF15</b>"]
    Ms{"Ms"}
    TAF15 -->|"expressed in"| Ms
    Cancer{"Cancer"}
    TAF15 -->|"expressed in"| Cancer
    FUS["FUS"]
    TAF15 -->|"associated with"| FUS
    EWSR1["EWSR1"]
    TAF15 -->|"associated with"| EWSR1
    DDIT3["DDIT3"]
    TAF15 -->|"associated with"| DDIT3
    neurodegeneration["neurodegeneration"]
    TAF15 -->|"implicated in"| neurodegeneration
    style TAF15 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (64)

Target	Relation	Type	Str
Ftld-Fet	component_of	disease	0.90
neurons	expressed_in	cell_type	0.70
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Als	activates	disease	0.65
Dementia	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Aging	activates	disease	0.65
ALS	activates	disease	0.65
Als	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Huntington	regulates	disease	0.65
ALS	inhibits	disease	0.65
Anxiety	associated_with	disease	0.65
TAU	associated_with	entity	0.60
FUS	associated_with	gene	0.60
EWSR1	associated_with	gene	0.60
DDIT3	associated_with	gene	0.60
FUS	activates	gene	0.60
HNRNPA2B1	inhibits	gene	0.60
HNRPU	inhibits	gene	0.60
NUCLEOLIN	inhibits	gene	0.60
HNRNPA1	activates	gene	0.60
GAIN	associated_with	gene	0.60
HUNTINGTIN	regulates	gene	0.60
TDP-43	associated_with	gene	0.60
FUS	transports	gene	0.60
TARDBP	associated_with	gene	0.60
VAPB	associated_with	gene	0.60
VCP	associated_with	gene	0.60
Tdp-43	associated_with	pathway	0.60
DNA	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
RNA	expressed_in	gene	0.60
FTLD	associated_with	gene	0.60
Neuron	associated_with	cell_type	0.60
ALS	associated_with	gene	0.60
RNA	activates	gene	0.60
HUNTINGTON	regulates	gene	0.60
AMYLOID	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
Dna Repair	interacts_with	pathway	0.60
DEMENTIA	activates	gene	0.60
AND	associated_with	gene	0.60
Actin	interacts_with	protein	0.60

Incoming (62)

Source	Relation	Type	Str
FUS	associated_with	entity	0.60
UBIQUITIN	activates	gene	0.60
P62	activates	gene	0.60
TDP-43	associated_with	gene	0.60
HNRNPA2B1	inhibits	gene	0.60
HNRPU	inhibits	gene	0.60
NUCLEOLIN	inhibits	gene	0.60
SRPK1	inhibits	gene	0.60
FUS	transports	gene	0.60
GAIN	associated_with	gene	0.60
HNRNPA1	activates	gene	0.60
FUS	regulates	gene	0.60
HUNTINGTIN	regulates	gene	0.60
FUS	implicated_in	gene	0.60
SRPK1	interacts_with	gene	0.60
FUS	translocates_to	gene	0.60
ALS2	associated_with	gene	0.60
ANG	associated_with	gene	0.60
DAO	associated_with	gene	0.60
DCTN1	associated_with	gene	0.60
FIG4	associated_with	gene	0.60
NEFH	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
SETX	associated_with	gene	0.60
SPG11	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
AND	associated_with	gene	0.60
FTLD	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
ALS	activates	gene	0.60
AND	activates	gene	0.60
FTLD	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
AMYLOID	activates	gene	0.60
DEMENTIA	activates	gene	0.60
DNA	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
AND	inhibits	gene	0.60
FTLD	transports	gene	0.60
RNA	transports	gene	0.60
AND	transports	gene	0.60
ANXIETY	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
RNA	activates	gene	0.60
GENETIC MUTATIONS	associated_with	gene	0.60
DNA	regulates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TAF15

Understanding Entity Pages

Summary

Wiki Pages (21)

TAF15 Gene

Biomolecular Condensates in Neurodegeneration

TAR DNA-Binding Protein 43 (TDP-43)

FUS Mutations in Amyotrophic Lateral Sclerosis

frontotemporal-lobar-degeneration

FUS — Fused in Sarcoma

FUS (Fused in Sarcoma) Protein

FUS-Targeting Therapies for Amyotrophic Lateral Sclerosis

EWSR1 Protein

SPG11 Gene - Spastic Paraplegia 11

HNRNPU Gene

fus-phase-separation-neurodegeneration

RNA Splicing in Neurodegeneration

FUS Proteinopathy Neurons

FUS Protein

LLPS Modulator Therapy

FUS Proteinopathy

SPG11 Cytoskeletal Protein