HYPOTHALAMIC-PITUITARY-ADRENAL AXIS

Understanding Entity Pages

This page aggregates everything SciDEX knows about HYPOTHALAMIC-PITUITARY-ADRENAL AXIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    HYPOTHALAMIC_PITUITARY_ADRENAL["HYPOTHALAMIC-PITUITARY-ADRENAL AXIS"]
    HYPOTHALAMIC_PITUITARY_ADRENAL -->|"mediates"| Stress_Response["Stress Response"]
    HYPOTHALAMIC_PITUITARY_ADRENAL -->|"promotes"| inflammation["inflammation"]
    HYPOTHALAMIC_PITUITARY_ADRENAL -->|"contributes to"| Alopecia_Areata["Alopecia Areata"]
    HYPOTHALAMIC_PITUITARY_ADRENAL -->|"correlates_with"| Th1_Immune_Response["Th1 Immune Response"]
    HYPOTHALAMIC_PITUITARY_ADRENAL -->|"correlates_with"| Skin_Th1_Cytokines["Skin Th1 Cytokines"]
    HYPOTHALAMIC_PITUITARY_ADRENAL -->|"contributes to"| Sepsis_Associated_Encephalopat["Sepsis-Associated Encephalopathy"]
    psychological_stress["psychological stress"] -->|"activates"| HYPOTHALAMIC_PITUITARY_ADRENAL
    CRH["CRH"] -->|"component_of"| HYPOTHALAMIC_PITUITARY_ADRENAL
    AVP["AVP"] -->|"component_of"| HYPOTHALAMIC_PITUITARY_ADRENAL
    CRHR1["CRHR1"] -->|"component_of"| HYPOTHALAMIC_PITUITARY_ADRENAL
    CRHR2["CRHR2"] -->|"component_of"| HYPOTHALAMIC_PITUITARY_ADRENAL
    NR3C1["NR3C1"] -->|"regulates"| HYPOTHALAMIC_PITUITARY_ADRENAL
    NR3C2["NR3C2"] -->|"regulates"| HYPOTHALAMIC_PITUITARY_ADRENAL
    alopecia_areata["alopecia areata"] -->|"associated_with_higher_tone"| HYPOTHALAMIC_PITUITARY_ADRENAL