pathway

inflammation

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about inflammation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13905Connections

6Hypotheses

23Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	inflammation
Key Genes/Proteins	TNF, STAT3, BECN1, TNF-α, RIPK1, LUZP1
Related Diseases	depression, age-related diseases, Metabolic Dysfunction-Associated Fatty Liver Disease
Related Pathways	IL6/JAK/STAT3 pathway, PI3K-AKT signaling pathway, hypothalamic-pituitary-adrenal axis
Linked Hypotheses	7 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    inflammation["inflammation"] -->|"causes"| neuronal_cell_death["neuronal cell death"]
    style neuronal_cell_death fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    inflammation["inflammation"] -.->|"inhibits"| LDLR["LDLR"]
    style LDLR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    inflammation["inflammation"] -->|"causes"| Alzheimer_s_disease["Alzheimer's disease"]
    style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    inflammation["inflammation"] -->|"associated"| Parkinson_s_disease["Parkinson's disease"]
    style Parkinson_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    inflammation["inflammation"] -->|"causes"| neurodegeneration["neurodegeneration"]
    style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    inflammation["inflammation"] -->|"causes"| depression["depression"]
    style depression fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    inflammation["inflammation"] -->|"associated"| cognitive_deficits["cognitive deficits"]
    style cognitive_deficits fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    BECN1["BECN1"] -.->|"inhibits"| inflammation["inflammation"]
    style BECN1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    IL6_JAK_STAT3_pathway["IL6/JAK/STAT3 pathway"] -->|"causes"| inflammation["inflammation"]
    style IL6_JAK_STAT3_pathway fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#e0e0e0
    TNF__["TNF-alpha"] -->|"causes"| inflammation["inflammation"]
    style TNF__ fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    HO_1["HO-1"] -.->|"inhibits"| inflammation["inflammation"]
    style HO_1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    PIEZO1["PIEZO1"] -->|"activates"| inflammation["inflammation"]
    style PIEZO1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style inflammation fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (6041)

Target	Relation	Type	Str
hepatocyte death	drives	process	0.92
depression	promotes	disease	0.90
age-related diseases	drives	disease	0.90
Metabolic Dysfunction-Associated Fatty Liver Disease	drives	disease	0.90
aging	drives	process	0.85
lung	associated_with	brain_region	0.85
Delirium	drives	disease	0.85
Hk2-Pink1	activates	pathway	0.85
neuronal cell death	causes	phenotype	0.80
LDLR	inhibits	gene	0.80
choroidal neovascularization	promotes	phenotype	0.80
senescence	promotes	process	0.80
HK2-PINK1 pathway	activates	pathway	0.80
orthodontic tooth movement	modulates	process	0.75
Alzheimer's disease	activates	disease	0.70
Parkinson's disease	associated_with	disease	0.70
Parkinson's disease	causes	disease	0.70
neurodegeneration	causes	disease	0.70
depression	causes	disease	0.70
cognitive deficits	associated_with	process	0.70
Alzheimer's disease and related dementias	associated_with	disease	0.70
ion imbalance	causes	process	0.70
excitotoxicity	causes	process	0.70
epigenetic dysregulation	causes	process	0.70
retinal neurodegeneration	promotes	process	0.70
fibrosis	activates	phenotype	0.64
PIEZO1	regulates	gene	0.56
PIEZO2	regulates	gene	0.56
HCC	contributes_to	disease	0.56
Sphingolipid	associated_with	pathway	0.50
disease	associated_with	disease	0.50
Inflammatory Bowel Disease	associated_with	disease	0.50
CERAMIDE	interacts_with	concept	0.50
CERAMIDE	regulates	concept	0.50
CHRONIC INFLAMMATION	interacts_with	concept	0.50
oxidative stress	activates	phenotype	0.50
CELL DEATH	causes	concept	0.50
Infection	causes	disease	0.50
DNA DAMAGE	activates	concept	0.50
CHRONIC INFLAMMATION	activates	concept	0.50
disease	regulates	disease	0.50
Macrophage	regulates	cell_type	0.50
MACROPHAGES	regulates	concept	0.50
disease	activates	disease	0.50
atherosclerosis	activates	disease	0.50
FIBROSIS	inhibits	disease	0.50
Macrophage	inhibits	cell_type	0.50
MACROPHAGES	inhibits	concept	0.50
FIBROSIS	activates	disease	0.50
Macrophage	activates	cell_type	0.50

Incoming (7864)

Source	Relation	Type	Str
TNF	promotes	protein	0.95
STAT3	promotes	protein	0.92
BECN1	inhibits	gene	0.90
IL6/JAK/STAT3 pathway	causes	pathway	0.90
TNF-α	causes	protein	0.90
PI3K-AKT signaling pathway	promotes	pathway	0.90
RIPK1	promotes	protein	0.90
LUZP1	inhibits	protein	0.90
NLRP3	promotes	protein	0.90
ferritinophagy	promotes	process	0.90
hypothalamic-pituitary-adrenal axis	promotes	pathway	0.90
NLRP3	involved_in	gene	0.90
NLRP3 inflammasome activation	drives	process	0.90
Artemisia annua	inhibits	compound	0.90
116B	suppresses	compound	0.90
M1-type macrophages	promotes	cell_type	0.90
ALOX15	promotes	gene	0.90
ANXA1	suppresses	protein	0.90
TREM2/TYROBP signaling pathway	modulates	pathway	0.88
HDAC3	promotes	protein	0.88
IL1B	mediates	protein	0.88
TFAM	suppresses	protein	0.88
PI3K-AKT signaling pathway	regulates	pathway	0.87
NLRP3	regulates	protein	0.85
itaconate	prevents	metabolite	0.85
metabolic dysregulation	promotes	process	0.85
apoptotic pathways	modulates	pathway	0.85
sesquiterpenoids	modulates	compound	0.85
HK2	promotes	gene	0.85
very long chain ceramides	promotes	compound	0.85
MAPK	drives	protein	0.85
CHIP	promotes	process	0.85
PIEZO1 deletion	suppresses	phenotype	0.85
PI3K-Akt signaling pathway	regulates	pathway	0.82
HO-1	inhibits	protein	0.80
PIEZO1	activates	protein	0.80
AGE-RAGE pathway	causes	pathway	0.80
SIRT1	regulates	protein	0.80
TGN-020	treats	drug	0.80
IL-10	associated_with	entity	0.80
NRF2	modulates	protein	0.80
SIRT1	modulates	protein	0.80
SIRT1	inhibits	gene	0.80
Luteolin	inhibits	compound	0.80
Alox12	promotes	protein	0.80
TGM2	associated_with	gene	0.80
Piezo1	inhibits	gene	0.80
efferocytosis	inhibits	process	0.80
ACBA	inhibits	drug	0.75
LCN2	promotes	protein	0.75

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone	0.645	neurodegeneration	What are the precise temporal dynamics o
STING Antagonism Prevents Acute-to-Chronic Neuroinflammation	0.605	neuroinflammation	What molecular mechanisms drive the tran
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43	0.601	neurodegeneration	What are the mechanisms by which gut mic
Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammatio	0.486	translational neuroscience	Which metabolic biomarkers can distingui
Soluble TREM2 (sTREM2) as Therapeutic Mimic — Decoupling Pha	0.452	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro

Cardiovascular-Neuroinflammation Crosstalk Interruption	0.437	Alzheimer's disease	Neuroinflammation and microglial priming

Mentioning Analyses (23)

Scientific analyses that reference this entity

What molecular mechanisms drive the transition from acute to persistent neuroinf

neuroinflammation | 2026-04-15 | 2 hypotheses Top: 0.605

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

neurodegeneration | 2026-04-14 | 0 hypotheses

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.632

What molecular mechanisms underlie the dose-dependent protective effects of the

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.473

What are the specific molecular mechanisms by which peripheral monocytes cross t

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.584

Related Papers (8)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Complement C1q-Targeted Microglial Membrane Camouflaged Nanolipid Carriers for S [PMID:41114949]	Ding YN, Li MQ, Ding PT, Wang P, Guan PP	Nano letters	2026	1
Systemic inflammation as a central player in the initiation and development of A [PMID:40841660]	Bayraktaroglu I, Ortí-Casañ N, Van Dam D	Immunity & ageing : I & A	2025	1
Cerium-doped Prussian blue biomimetic nanozyme as an amplified pyroptosis inhibi [PMID:40050873]	Ma J, Tian Y, Du C, Zhu Y, Huang W, Ding	Journal of nanobiotechnology	2025	1
Interactions between antidiabetes medications and heart-brain axis. [PMID:39639832]	Ong LT, Sia CH	Current opinion in endocrinolo	2025	1
The Molecular Mechanisms of Cognitive Dysfunction in Long COVID: A Narrative Rev [PMID:40507911]	Popa E, Popa AE, Poroch M, Poroch V, Ung	International journal of molec	2025	1
Obesity-induced pyroptotic adipocyte death leads to TREM2-dependent macrophage d [PMID:41509917]	Choi C, Lee J, Park G, Namgoong S, Lee Y	iScience	2026	0
Air pollution, glymphatic impairment, and Alzheimer's disease. [PMID:37777345]	Hussain R, Graham U, Elder A, Nedergaard	Trends in neurosciences	2023	0
Molecular biomarkers for vascular cognitive impairment and dementia. [PMID:37957261]	Hosoki S, Hansra GK, Jayasena T, Poljak	Nature reviews. Neurology	2023	0

inflammation

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Pathway Diagram

Outgoing (6041)

Incoming (7864)

Targeting Hypotheses (6)

Mentioning Analyses (23)

What molecular mechanisms drive the transition from acute to persistent neuroinf

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

What molecular mechanisms underlie the dose-dependent protective effects of the

What are the specific molecular mechanisms by which peripheral monocytes cross t

Can TREM2 receptor switching from agonism to antagonism be achieved safely witho

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

Which specific metabolic pathways in APOE4+ microglia are most therapeutically t

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

Can circadian interventions reverse microglial priming independent of sleep disr

What specific astrocyte-derived factors can 'erase' pathological microglial memo

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

What determines the selectivity of complement-mediated synaptic elimination in p

What causes IBA1 low/negative microglia in liver disease and how does this affec

Do microglia actually switch between glycolytic and oxidative phosphorylation as

Neuroinflammation and microglial priming in early AD

Neuroinflammation and microglial priming in early Alzheimer's Disease

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

Neuroinflammation resolution mechanisms and pro-resolving mediators

Senolytic therapy for age-related neurodegeneration

Neuroinflammation resolution mechanisms and pro-resolving mediators

Related Papers (8)

inflammation

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alzheimer's Disease Mechanism Index

nhp-validation-animal-model

nimodipine-als

Neuroresilience Mechanisms and Evidence

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

CBS/PSP Treatment Rankings

Pathway Diagram

Outgoing (6041)

Incoming (7864)

Targeting Hypotheses (6)

Mentioning Analyses (23)

What molecular mechanisms drive the transition from acute to persistent neuroinf

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

What molecular mechanisms underlie the dose-dependent protective effects of the

What are the specific molecular mechanisms by which peripheral monocytes cross t

Can TREM2 receptor switching from agonism to antagonism be achieved safely witho

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

Which specific metabolic pathways in APOE4+ microglia are most therapeutically t

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

Can circadian interventions reverse microglial priming independent of sleep disr

What specific astrocyte-derived factors can 'erase' pathological microglial memo

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

What determines the selectivity of complement-mediated synaptic elimination in p

What causes IBA1 low/negative microglia in liver disease and how does this affec

Do microglia actually switch between glycolytic and oxidative phosphorylation as

Neuroinflammation and microglial priming in early AD

Neuroinflammation and microglial priming in early Alzheimer's Disease

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

Neuroinflammation resolution mechanisms and pro-resolving mediators

Senolytic therapy for age-related neurodegeneration

Neuroinflammation resolution mechanisms and pro-resolving mediators

Related Papers (8)