gene

AVP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AVP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

135Connections
0Hypotheses
0Analyses
50Outgoing
45Incoming

Summary

AVP is a gene implicated in neurodegeneration research. Key relationships include: expressed in, activates, regulates. Associated with ALS, Als, Cardiovascular. Connected to 43 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolAVP
Chromosome20p13
FunctionThe AVP gene encodes preprovasopressin, which is processed to mature AVP (arginine vasopressin) along with neurophysin I and a glycopeptide.
Primary Expressionbrain regions involved in social and homeostatic functions:
PathwaysChaperone
Ensembl IDENSG00000101290
GeneCardsAVP
Human Protein AtlasAVP
Associated DiseasesAlopecia Areata, Alzheimer, Cancer, Cardiovascular, Diabetes, Hypertension
InteractionsJUN, CLOCK, Rb, CRH, FKBP5, NR3C1
KG Connections135 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

AVP Gene

gene · 926 words

calcium-dysregulation-comparison

mechanism · 6468 words

cerebral-cortical-vasal-neurons

cell_type · 4639 words

Paraventricular Hypothalamic Nucleus (PVN) Neurons

cell · 4274 words

Sleep and Neurodegeneration

mechanism · 3566 words

HPA Axis Dysfunction in Neurodegeneration

mechanism · 3381 words

Pathway Diagram

graph TD
    AVP["<b>AVP</b>"]
    Tumor{"Tumor"}
    AVP -->|"expressed in"| Tumor
    Als{"Als"}
    AVP -->|"activates"| Als
    Diabetes{"Diabetes"}
    AVP -->|"activates"| Diabetes
    Ms{"Ms"}
    AVP -->|"contributes to"| Ms
    Heart_Failure{"Heart Failure"}
    AVP -->|"activates"| Heart_Failure
    AVP -->|"regulates"| Diabetes
    AVP -->|"regulates"| Ms
    Cardiovascular{"Cardiovascular"}
    AVP -->|"regulates"| Cardiovascular
    ALS{"ALS"}
    AVP -->|"activates"| ALS
    POMC["POMC"]
    AVP -->|"expressed in"| POMC
    CRHR1["CRHR1"]
    AVP -->|"expressed in"| CRHR1
    NR3C1["NR3C1"]
    AVP -->|"expressed in"| NR3C1
    CRH["CRH"]
    CRH -->|"expressed in"| AVP
    AQP4["AQP4"]
    AQP4 -->|"expressed in"| AVP
    MICROTUBULES["MICROTUBULES"]
    MICROTUBULES -->|"regulates"| AVP
    POMC -->|"expressed in"| AVP
    CRHR1 -->|"expressed in"| AVP
    AND["AND"]
    AND -->|"expressed in"| AVP
    TNF["TNF"]
    TNF -->|"expressed in"| AVP
    ESR1["ESR1"]
    ESR1 -->|"expressed in"| AVP
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"activates"| AVP
    JUN["JUN"]
    JUN -->|"activates"| AVP
    ESR2["ESR2"]
    ESR2 -->|"expressed in"| AVP
    NR3C1 -->|"expressed in"| AVP
    style AVP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (90)

TargetRelationTypeStr
ACTHassociated_withprotein0.90
Hypothalamic-Pituitary-Adrenal Axiscomponent_ofpathway0.90
Alopecia Areataassociated_withdisease0.85
Alopecia Areataupregulatesdisease0.85
Suprachiasmatic Nucleusexpressed_incell_type0.80

Incoming (45)

SourceRelationTypeStr
CRHexpressed_ingene0.60
AQP4expressed_ingene0.60
POMCexpressed_ingene0.60
CRHR1expressed_ingene0.60
TNFexpressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found