Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AVP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
AVP is a gene implicated in neurodegeneration research. Key relationships include: expressed in, activates, regulates. Associated with ALS, Als, Cardiovascular. Connected to 43 entities in the SciDEX knowledge graph.
| Gene Symbol | AVP |
| Chromosome | 20p13 |
| Function | The AVP gene encodes preprovasopressin, which is processed to mature AVP (arginine vasopressin) along with neurophysin I and a glycopeptide. |
| Primary Expression | brain regions involved in social and homeostatic functions: |
| Pathways | Chaperone |
| Ensembl ID | ENSG00000101290 |
| GeneCards | AVP |
| Human Protein Atlas | AVP |
| Associated Diseases | Alopecia Areata, Alzheimer, Cancer, Cardiovascular, Diabetes, Hypertension |
| Interactions | JUN, CLOCK, Rb, CRH, FKBP5, NR3C1 |
| KG Connections | 135 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
AVP["<b>AVP</b>"]
Tumor{"Tumor"}
AVP -->|"expressed in"| Tumor
Als{"Als"}
AVP -->|"activates"| Als
Diabetes{"Diabetes"}
AVP -->|"activates"| Diabetes
Ms{"Ms"}
AVP -->|"contributes to"| Ms
Heart_Failure{"Heart Failure"}
AVP -->|"activates"| Heart_Failure
AVP -->|"regulates"| Diabetes
AVP -->|"regulates"| Ms
Cardiovascular{"Cardiovascular"}
AVP -->|"regulates"| Cardiovascular
ALS{"ALS"}
AVP -->|"activates"| ALS
POMC["POMC"]
AVP -->|"expressed in"| POMC
CRHR1["CRHR1"]
AVP -->|"expressed in"| CRHR1
NR3C1["NR3C1"]
AVP -->|"expressed in"| NR3C1
CRH["CRH"]
CRH -->|"expressed in"| AVP
AQP4["AQP4"]
AQP4 -->|"expressed in"| AVP
MICROTUBULES["MICROTUBULES"]
MICROTUBULES -->|"regulates"| AVP
POMC -->|"expressed in"| AVP
CRHR1 -->|"expressed in"| AVP
AND["AND"]
AND -->|"expressed in"| AVP
TNF["TNF"]
TNF -->|"expressed in"| AVP
ESR1["ESR1"]
ESR1 -->|"expressed in"| AVP
CYTOKINES["CYTOKINES"]
CYTOKINES -->|"activates"| AVP
JUN["JUN"]
JUN -->|"activates"| AVP
ESR2["ESR2"]
ESR2 -->|"expressed in"| AVP
NR3C1 -->|"expressed in"| AVP
style AVP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ACTH | associated_with | protein | 0.90 |
| Hypothalamic-Pituitary-Adrenal Axis | component_of | pathway | 0.90 |
| Alopecia Areata | associated_with | disease | 0.85 |
| Alopecia Areata | upregulates | disease | 0.85 |
| Suprachiasmatic Nucleus | expressed_in | cell_type | 0.80 |
| Suicide Risk | risk_factor_for | phenotype | 0.75 |
| CRH | interacts_with | gene | 0.70 |
| Ptsd | associated_with | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Diabetes | activates | disease | 0.65 |
| Ms | contributes_to | disease | 0.65 |
| Heart Failure | activates | disease | 0.65 |
| Diabetes | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Cardiovascular | regulates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Cardiovascular | implicated_in | disease | 0.65 |
| Heart Failure | biomarker_for | disease | 0.65 |
| Stroke | biomarker_for | disease | 0.65 |
| Myocardial Infarction | biomarker_for | disease | 0.65 |
| Diabetes | causes | disease | 0.65 |
| Infection | activates | disease | 0.65 |
| Ischemia | activates | disease | 0.65 |
| Diabetes | associated_with | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Ataxia | expressed_in | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Alzheimer | expressed_in | disease | 0.65 |
| Depression | expressed_in | disease | 0.65 |
| Hypertension | associated_with | disease | 0.65 |
| POMC | expressed_in | gene | 0.60 |
| CRHR1 | expressed_in | gene | 0.60 |
| NR3C1 | expressed_in | gene | 0.60 |
| JUN | activates | gene | 0.60 |
| ESR1 | expressed_in | gene | 0.60 |
| TNF | expressed_in | gene | 0.60 |
| ESR2 | expressed_in | gene | 0.60 |
| CRH | expressed_in | gene | 0.60 |
| AQP4 | expressed_in | gene | 0.60 |
| FKBP5 | associated_with | gene | 0.60 |
| CRH | associated_with | gene | 0.60 |
| NR3C1 | associated_with | gene | 0.60 |
| POMC | associated_with | gene | 0.60 |
| CRH | contributes_to | gene | 0.60 |
| CLOCK | inhibits | gene | 0.60 |
| Rb | activates | protein | 0.60 |
| Rb | inhibits | protein | 0.60 |
| FKBP5 | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CRH | expressed_in | gene | 0.60 |
| AQP4 | expressed_in | gene | 0.60 |
| POMC | expressed_in | gene | 0.60 |
| CRHR1 | expressed_in | gene | 0.60 |
| TNF | expressed_in | gene | 0.60 |
| ESR1 | expressed_in | gene | 0.60 |
| JUN | activates | gene | 0.60 |
| ESR2 | expressed_in | gene | 0.60 |
| NR3C1 | expressed_in | gene | 0.60 |
| OVERVIEW | therapeutic_target | gene | 0.60 |
| REST | expressed_in | gene | 0.60 |
| ATXN3 | expressed_in | gene | 0.60 |
| BMAL1 | expressed_in | gene | 0.60 |
| PER2 | expressed_in | gene | 0.60 |
| CLOCK | inhibits | gene | 0.60 |
| CRH | biomarker_for | gene | 0.60 |
| NR3C1 | biomarker_for | gene | 0.60 |
| TAC1 | biomarker_for | gene | 0.60 |
| FOXP1 | biomarker_for | gene | 0.60 |
| CRH | associated_with | gene | 0.60 |
| POMC | associated_with | gene | 0.60 |
| NR3C1 | associated_with | gene | 0.60 |
| CRH | contributes_to | gene | 0.60 |
| MICROTUBULES | regulates | gene | 0.60 |
| CYTOKINES | activates | gene | 0.60 |
| STROKE | biomarker_for | gene | 0.60 |
| GENES | causes | gene | 0.60 |
| NEUROTOXICITY | activates | gene | 0.60 |
| CIRCADIAN RHYTHM | expressed_in | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| CLOCK GENE | inhibits | gene | 0.60 |
| IL12 | expressed_in | gene | 0.60 |
| NR3C2 | expressed_in | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| DEPRESSION | expressed_in | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
| AND | biomarker_for | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| ALZHEIMER | expressed_in | gene | 0.60 |
| AND | contributes_to | gene | 0.60 |
| ALZHEIMER'S DISEASE | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||