gene

CD19

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD19: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

182Connections

0Hypotheses

0Analyses

50Outgoing

41Incoming

Summary

CD19 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, regulates, interacts with. Associated with ALS, Aging, Als. Connected to 115 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CD19
Full Name	CD19 Molecule
Chromosome	16p11.2
Function	is a member of the immunoglobulin superfamily and functions as a critical signaling co-receptor on the surface of B cells.
Pathways	PI3K, PI3K Pathway, NF-κB
UniProt ID	P15391
NCBI Gene ID	933
Ensembl ID	ENSG00000177455
OMIM	107741
GeneCards	CD19
Human Protein Atlas	CD19
Associated Diseases	ALS, Autoimmune, Cancer, Inflammation, Lymphoma, Multiple Sclerosis
Known Drugs/Compounds	Inebilizumab-Cdon
Interactions	EEF2, CCL5, TNF, TLR7, CAT, ACTB
KG Connections	181 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CD19 — AlphaFold P15391 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CD19["CD19"]
    CD19 -.biomarker for.-> MS["MS"]
    CD19 -->|"target for"| Multiple_Sclerosis["Multiple Sclerosis"]
    CD19 -->|"target for"| Inflammation["Inflammation"]
    CD19 -->|"target for"| Als["Als"]
    CD19 -->|"target for"| Neuroinflammation["Neuroinflammation"]
    CD19 -->|"target for"| Autoimmune["Autoimmune"]
    CD19 -->|"target for"| Ms["Ms"]
    CD19 -->|"target for"| Leukemia["Leukemia"]
    CD19 -->|"regulates"| Cancer["Cancer"]
    AQP4["AQP4"] -->|"inhibits"| CD19
    ATG3["ATG3"] -->|"regulates"| CD19
    IRF1["IRF1"] -->|"regulates"| CD19
    TNF["TNF"] -->|"regulates"| CD19
    STAT1["STAT1"] -->|"regulates"| CD19
    GENES["GENES"] -->|"regulates"| CD19
    RB1CC1["RB1CC1"] -->|"regulates"| CD19
    TNFR1["TNFR1"] -->|"regulates"| CD19
    CD4["CD4"] -->|"interacts"| CD19
    MAPK3["MAPK3"] -->|"interacts"| CD19

Outgoing (140)

Target	Relation	Type	Str
Als	therapeutic_target	disease	0.95
NEUROMYELITIS OPTICA SPECTRUM DISORDER	therapeutic_target	entity	0.90
CD4	associated_with	gene	0.80
CD8	associated_with	gene	0.80
macrophages	expressed_in	cell_type	0.80
Multiple Sclerosis	therapeutic_target	disease	0.75
Lymphoma	therapeutic_target	disease	0.75
B Cell Activation	regulates	process	0.70
MS	biomarker_for	disease	0.70
Checkpoint Inhibitor	therapeutic_target	pathway	0.70
T cells	expressed_in	cell_type	0.70
microglia	expressed_in	cell_type	0.70
Inflammation	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Tumor	associated_with	disease	0.65
Lymphoma	associated_with	disease	0.65
Ms	regulates	disease	0.65
Autoimmune	associated_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Autism	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Neuroinflammation	causes	disease	0.65
Inflammation	causes	disease	0.65
Multiple Sclerosis	causes	disease	0.65
ALS	causes	disease	0.65
Autoimmune	causes	disease	0.65
Infection	therapeutic_target	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	causes	disease	0.65
Cancer	biomarker_for	disease	0.65
BECN1	regulates	gene	0.60
CD47	therapeutic_target	gene	0.60
GBM	therapeutic_target	gene	0.60
EEF2	interacts_with	gene	0.60
CCL5	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
TLR7	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
RAC2	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
CDK4	interacts_with	gene	0.60
CDKN1A	interacts_with	gene	0.60

Incoming (42)

Source	Relation	Type	Str
Inebilizumab-Cdon	targets	drug	0.85
BCL2	therapeutic_target	gene	0.70
MYC	therapeutic_target	gene	0.70
AQP4	inhibits	gene	0.60
ATG3	regulates	gene	0.60
IRF1	regulates	gene	0.60
TNF	regulates	gene	0.60
STAT1	regulates	gene	0.60
RB1CC1	regulates	gene	0.60
TNFR1	regulates	gene	0.60
CD4	interacts_with	gene	0.60
MAPK3	interacts_with	gene	0.60
ZAP70	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
CD47	therapeutic_target	gene	0.60
AQP4	therapeutic_target	gene	0.60
FAS	regulates	gene	0.60
SF3B1	therapeutic_target	gene	0.60
CDK1	inhibits	gene	0.60
GBM	therapeutic_target	gene	0.60
BECN1	regulates	gene	0.60
C5	inhibits	gene	0.60
GENES	regulates	gene	0.60
MIRNAS	regulates	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
PHAGOCYTOSIS	therapeutic_target	gene	0.60
COMPLEMENT	inhibits	gene	0.60
ASTROCYTES	causes	gene	0.60
GLIOBLASTOMA	therapeutic_target	gene	0.60
APOPTOSIS	regulates	gene	0.60
AUTOPHAGY-RELATED GENES	regulates	gene	0.60
ASTROCYTE	causes	gene	0.60
NEUROINFLAMMATION	causes	gene	0.60
ASTROCYTE	therapeutic_target	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
RNA	associated_with	gene	0.60
AND	associated_with	gene	0.60
CANCER	causes	gene	0.60
ATG3	co_expressed_with	gene	0.50
BECN1	co_expressed_with	gene	0.50
CANCER	co_discussed	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CD19

Understanding Entity Pages

Summary

Wiki Pages (21)

CD19 Gene

Ion Channel Dysfunction in ALS

Neuromyelitis Optica Spectrum Disorder (NMOSD)

Paraneoplastic Cerebellar Degeneration Neurons

CSF1R Modulation Therapy: Microglia Reset Protocol

ATG3 Gene

Limbic Encephalitis Recovery and Residual Neuronal Changes

Walter A. Kukull

Asterias Biotherapy

CR2 (Complement Receptor Type 2)

Rituximab

Experimental: CAAR-T Cell Therapy for Autoantibody-Mediated Neurotoxicity in AD

Adaptive Immunity in Neurodegeneration: Investment Landscape

Tertiary Lymphoid Organs in Neurodegeneration

FOXP1 Protein

UAB TSPO PET Neuroinflammation in PD Trial

B Cells (B Lymphocytes)

Oligodendrocyte Precursor Cell Therapy