concept

B CELLS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about B CELLS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

208Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	B CELLS
Key Genes/Proteins	NF-KB, MOG, AQP4, CXCL10, BDNF
Related Diseases	LYMPHOMA, ROS, AGING
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    B_CELLS["B CELLS"]
    B_CELLS -->|"mediates"| Tolerance_To_AQP4["Tolerance To AQP4"]
    B_CELLS -->|"activates"| NF_KB["NF-KB"]
    B_CELLS -->|"regulates"| Immune_Tolerance["Immune Tolerance"]
    B_CELLS -->|"contributes to"| Salivary_Gland_Damage["Salivary Gland Damage"]
    B_CELLS -->|"regulates"| AQP4["AQP4"]
    B_CELLS -->|"involved_in"| Neuromyelitis_Optica["Neuromyelitis Optica"]
    DDX5["DDX5"] -->|"regulates"| B_CELLS
    APOPTOSIS["APOPTOSIS"] -->|"activates"| B_CELLS
    AQP4 -->|"activates"| B_CELLS
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| B_CELLS
    AKT["AKT"] -->|"activates"| B_CELLS

Outgoing (96)

Target	Relation	Type	Str
Tolerance To AQP4	mediates	process	0.95
Tolerance	mediates	process	0.95
NF-KB	activates	gene	0.95
Immune Tolerance	regulates	process	0.90
Salivary Gland Damage	contributes_to	phenotype	0.90
AQP4	regulates	protein	0.90
AQP4	regulates	protein	0.90
Neuromyelitis Optica	involved_in	disease	0.85
AQP4	interacts_with	protein	0.85
AQP4	modulates	protein	0.85
Immune Tolerance	mediates	process	0.85
Autoimmune Tolerance	regulates	process	0.85
Neuromyelitis Optica	protects_against	disease	0.85
Autoimmune Response	suppresses	process	0.85
Autoimmune Disease	participates_in	disease	0.80
AQP4	associated_with	protein	0.80
Immune Tolerance	mediates	process	0.80
neuromyelitis optica spectrum disorder	biomarker_for	disease	0.80
central nervous system	involved_in	brain_region	0.80
MS	associated_with	disease	0.80
LYMPHOMA	activates	disease	0.80
T CELLS	interacts_with	cell_type	0.80
Neuromyelitis optica spectrum disorder activity	related_to	disease	0.70
MACROPHAGES	treats	cell_type	0.70
T CELLS	activates	cell_type	0.65
LYMPHOMA	interacts_with	disease	0.65
LYMPHOMA	regulates	disease	0.65
INFLAMMATION	activates	process	0.65
LYMPHOMA	inhibits	disease	0.65
LYMPHOMA	depleted_in	disease	0.55
MULTIPLE SCLEROSIS	implicated_in	disease	0.55
BCL2	interacts_with	gene	0.50
BAX	interacts_with	gene	0.50
IL-6	activates	gene	0.50
CASP3	activates	gene	0.50
BCL2	activates	gene	0.50
ENDOTHELIAL CELLS	interacts_with	cell_type	0.50
FIBROBLASTS	interacts_with	cell_type	0.50
MACROPHAGES	activates	cell_type	0.50
LYMPHOMA	associated_with	disease	0.50
DENDRITIC CELLS	associated_with	concept	0.50
PURINERGIC SIGNALING	regulates	process	0.35
IL-6	inhibits	gene	0.35
COMPLEMENT	inhibits	protein	0.35
FOXO1	interacts_with	gene	0.35
NICOTINAMIDE	activates	drug	0.35
MYC	activates	gene	0.35
HEPATOCELLULAR CARCINOMA	activates	disease	0.35
OXIDATIVE STRESS	activates	process	0.35
RAPAMYCIN	activates	drug	0.35

Incoming (112)

Source	Relation	Type	Str
NF-kB signaling	active_in	pathway	0.90
DDX5	regulates	gene	0.80
spinal muscular atrophy	affects	disease	0.80
CD8	associated_with	gene	0.70
CD4	associated_with	gene	0.70
MOG	exacerbates	gene	0.70
unfolded protein response	active_in	pathway	0.70
AQP4	treats	gene	0.65
CXCL10	activates	gene	0.65
ROS	activates	phenotype	0.65
AGING	activates	phenotype	0.65
BDNF	activates	gene	0.65
AQP4	associated_with	gene	0.60
AQP4	activates	gene	0.60
AQP4	expressed_in	gene	0.60
AQP4	inhibits	gene	0.60
AQP4	treats	gene	0.60
Golgi apparatus	found_in	organelle	0.60
NAMPT	activates	gene	0.60
MYC	activates	gene	0.60
MYC	expressed_in	gene	0.60
GFAP	activates	gene	0.60
GFAP	regulates	gene	0.60
BCL2	regulates	gene	0.60
BCL2	releases	gene	0.60
AMPK signaling	active_in	pathway	0.60
NMDA receptor	expressed_in	receptor	0.60
glutamate signaling	active_in	pathway	0.60
IL1B	associated_with	gene	0.60
CD38	regulates	gene	0.60
NAD	activates	gene	0.60
DNA	regulates	gene	0.60
DNA	modulates	gene	0.60
ATP	activates	gene	0.60
ATP	regulates	gene	0.60
RNA	expressed_in	gene	0.60
glioblastoma	affects	disease	0.60
TLR	activates	gene	0.60
AMPK	activates	gene	0.60
multiple sclerosis	affects	disease	0.60
RNA	associated_with	gene	0.60
AGING	participates_in	phenotype	0.55
APOPTOSIS	activates	process	0.50
AQP4	associated_with	gene	0.50
CD40	activates	gene	0.50
T Cell	activates	cell_type	0.50
T CELLS	activates	concept	0.50
AQP4	interacts_with	gene	0.50
CD40	interacts_with	gene	0.50
disease	interacts_with	disease	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ	0.612	neuroinflammation	How do B cells mechanistically orchestra

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do B cells mechanistically orchestrate tolerance to AQP4 and prevent autoimm

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.612

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

B CELLS

Understanding Entity Pages

Wiki Pages (20)

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