concept

IGG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

2Hypotheses

17Analyses

2Outgoing

4Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	IGG
Key Genes/Proteins	FCGRT
Linked Hypotheses	2 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    IGG["IGG"]
    IGG -->|"activates"| AKT["AKT"]
    IGG -->|"binds"| FCGR2A["FCGR2A"]
    IGG -->|"modulates"| Inflammatory_Response["Inflammatory Response"]
    IGG -->|"binds_to"| AQP4["AQP4"]
    IGG -->|"correlates_with"| B_Cell_Surface["B Cell Surface"]
    FcRn["FcRn"] -->|"binds"| IGG
    FCRN["FCRN"] -->|"binds_to"| IGG
    FCGRT["FCGRT"] -->|"encodes"| IGG
    ST6GAL1["ST6GAL1"] -->|"modulates"| IGG
    Fcrn["Fcrn"] -->|"binds"| IGG
    FUT8["FUT8"] -->|"modulates"| IGG

Outgoing (9)

Target	Relation	Type	Str
AKT	activates	entity	0.95
Glioblastoma Stem Cell Proliferation	associated_with	process	0.95

Incoming (14)

Source	Relation	Type	Str
FCRN	binds_to	entity	0.95
FCGRT	encodes	gene	0.95
FCGRT	regulates	gene	0.60
FCGRT	protects_against	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Su	0.562	neurodegeneration	What upstream mechanisms trigger p53 act
Magnetosonic-Triggered Transferrin Receptor Clustering	0.470	neurodegeneration	Blood-brain barrier transport mechanisms

Mentioning Analyses (17)

Scientific analyses that reference this entity

What determines the GPX4/ACSL4 balance that switches microglia from protective t

immunology | 2026-04-15 | 0 hypotheses

What are the precise temporal dynamics of astrocyte ketone production decline du

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.645

What upstream mechanisms trigger p53 activation specifically in response to poly

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.562

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.455

How does PIKFYVE inhibition activate unconventional protein clearance via exocyt

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.559

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease. [PMID:40425446]	Sehlin D, Hultqvist G, Michno W, Aguilar	J Prev Alzheimers Dis	2025	1
Effect of ferroptosis on chronic cerebral hypoperfusion in vascular dementia. [PMID:37709116]	Fu P, Chen Y, Wu M, Bao B, Yin X, Chen Z	Exp Neurol	2023	1
On Iron Metabolism and Its Regulation. [PMID:33925597]	Vogt AS, Arsiwala T, Mohsen M, Vogel M,	Int J Mol Sci	2021	1
Transferrin Receptor Is a Specific Ferroptosis Marker. [PMID:32160546]	Feng H, Schorpp K, Jin J, Yozwiak CE, Ho	Cell Rep	2020	1
Transferrin and transferrin receptors update. [PMID:29969719]	Kawabata H	Free Radic Biol Med	2019	1
A proimmunotoxin nanodrug targeting AIDS-associated non-Hodgkin lymphoma. [PMID:41592623]	Chen S, Qi T, Peng H, Kimura E, Zhang X	J Control Release	2026	0
Time- and dose-dependent effects of bacterial infection on iron metabolism, infl [PMID:41619877]	Lu Y, Zhang Y, Niu C	Comp Biochem Physiol A Mol Int	2026	0
Ayanin combats against barium sulphate nanoparticles induced hepatotoxicity via [PMID:41666660]	Zhu D, Lu Y, Jamil S, Ashfaq H, Al-Emam	J Trace Elem Med Biol	2026	0
Role of iron and TfR1 in the application of high‑dose ascorbate against pancreat [PMID:41789665]	Piotrowsky A, Leischner C, Schmieder H,	Oncol Rep	2026	0
Brain and Liver Dual-Targeting Oridonin Nanoparticles to Enhance Aβ Clearance fo [PMID:41944296]	Gong W, Hui W, Qiao S, Ji Q, Liu M et al	Adv Sci (Weinh)	2026	0
Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in [PMID:41947413]	Palsa K, Sahu AP, Rye DB, Trotti LM, Elc	Ann Neurol	2026	0
Pulmonary neuroendocrine cell-derived exosomes regulate iron homeostasis and oxi [PMID:41950316]	Thakur A, Zhang K, Chen J, Mei S, Chen J	Sci Adv	2026	0
O-GlcNAc Modification Orchestrates HUWE1-Mediated Ubiquitination of TfR1 to Regu [PMID:41962599]	Zhang H, Li M, Zhang J, Sun Q, Jin X et	Free Radic Biol Med	2026	0
Protective Role of Polydatin Against Vancomycin-Induced Lung Toxicity via Oxidat [PMID:41963266]	Aygörmez S, Küçükler S, Çomaklı S, Şimşe	J Appl Toxicol	2026	0
Yangxin granules exert cardioprotective effects against acute myocardial infarct [PMID:41868900]	Huo G, Zhou Y, Wu Z, Sun S, Zhu G, Cheng	American journal of translatio	2026	0
Conformational dynamics study of TfR1 upon transferrin binding via NMA and MD si [PMID:41921418]	Zemmouche M, Falque G, Cadet F, Gardebie	Journal of molecular graphics	2026	0
[Effects of acupuncture on ferroptosis and ferritinophagy in cerebral ischemia-r [PMID:41839581]	Wang YF, Dong YS	Zhen ci yan jiu = Acupuncture	2026	0
The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibit [PMID:41854751]	Nan K, Zhang L, Zhao Y, Yin S, Peng Y, H	Apoptosis : an international j	2026	0
The Role of Artemisinin and its Derivatives in Cancer Therapy via Ferroptosis: A [PMID:41833023]	Osmanlioglu Dag SR, Tatli Cankaya II, Oz	Anti-cancer agents in medicina	2026	0
Raccoon eyes. [PMID:35789012]	Ning J	Journal of paediatrics and chi	2023	0

IGG

Understanding Entity Pages

Wiki Pages (20)

Blood-Brain Barrier Biology and Crossing Strategies

blood-brain-barrier

PMN310 Anti-Amyloid for AD (NCT06750432)

Nanobody Therapy for Neurodegenerative Diseases

Bepranemab (UCB0107)

Pathway Diagram

Outgoing (9)

Incoming (14)

Targeting Hypotheses (2)

Mentioning Analyses (17)

What determines the GPX4/ACSL4 balance that switches microglia from protective t

What are the precise temporal dynamics of astrocyte ketone production decline du

What upstream mechanisms trigger p53 activation specifically in response to poly

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

How does PIKFYVE inhibition activate unconventional protein clearance via exocyt

How can CRISPR systems achieve persistent therapeutic effects while avoiding chr

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or c

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or e

What upstream mechanisms cause TDP-43 to trigger mPTP opening and can this be th

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

What determines the specificity of RNA-protein interactions that drive distinct

What determines the specificity of TDP-43-induced mitochondrial DNA release for

How do perivascular cells specifically recognize and respond to amyloid-β to upr

How do pathological stress granules transition from reversible to persistent in

How do disease-associated mutations in G3BP1 or its binding partners alter stres

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

Neuroinflammation and microglial priming in early Alzheimer's Disease

Related Papers (20)

IGG

Understanding Entity Pages

Wiki Pages (20)

Blood-Brain Barrier Biology and Crossing Strategies

blood-brain-barrier

PMN310 Anti-Amyloid for AD (NCT06750432)

Nanobody Therapy for Neurodegenerative Diseases

Bepranemab (UCB0107)

Multiple Sclerosis (MS)

neurovascular-dysfunction

AD Cure Roadmap — Integrated Timeline

Etalanetug (E2814)

Blood-Brain Barrier Breakdown in Neurodegeneration

Multifocal Motor Neuropathy (MMN)

DNL310

Adaptive Immunity in Neurodegeneration

Neuromyelitis Optica Spectrum Disorder (NMOSD)

Exosome Biogenesis in Neurodegeneration

ataxia-telangiectasia

Subacute Sclerosing Panencephalitis (SSPE)

viral-post-infectious-als

Polyneuron Pharmaceuticals AG

Tau Immunotherapy Mechanisms

Pathway Diagram

Outgoing (9)

Incoming (14)

Targeting Hypotheses (2)

Mentioning Analyses (17)

What determines the GPX4/ACSL4 balance that switches microglia from protective t

What are the precise temporal dynamics of astrocyte ketone production decline du

What upstream mechanisms trigger p53 activation specifically in response to poly

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

How does PIKFYVE inhibition activate unconventional protein clearance via exocyt

How can CRISPR systems achieve persistent therapeutic effects while avoiding chr

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or c

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or e

What upstream mechanisms cause TDP-43 to trigger mPTP opening and can this be th

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

What determines the specificity of RNA-protein interactions that drive distinct

What determines the specificity of TDP-43-induced mitochondrial DNA release for

How do perivascular cells specifically recognize and respond to amyloid-β to upr

How do pathological stress granules transition from reversible to persistent in

How do disease-associated mutations in G3BP1 or its binding partners alter stres

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

Neuroinflammation and microglial priming in early Alzheimer's Disease

Related Papers (20)