protein

TRANSFERRIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRANSFERRIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

140Connections
1Hypotheses
1Analyses
24Outgoing
13Incoming

Summary

Page for Transferrin Protein

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🔬 Protein Info
Gene SymbolTRANSFERRIN
Chromosome3q21.
Molecular Weight80 kDa
Amino Acids679 aa
PathwaysBlood-Brain Barrier, Oxidative Stress, Autophagy, Mitophagy, Mitochondrial Function
GeneCardsTRANSFERRIN
Human Protein AtlasTRANSFERRIN
Associated DiseasesISCHEMIA, cancer, ferroptosis
InteractionsProteins, IGF2R, SORTILIN, FERROPORTIN, HEPCIDIN, TFR1
KG Connections37 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Transferrin Protein

redirect · 668 words

cbs-psp-daily-action-plan

therapeutic · 30834 words

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

therapeutic · 6350 words

NRF2 Oxidative Stress Pathway

mechanism · 5315 words

Pathway Diagram

graph TD
    TRANSFERRIN["<b>TRANSFERRIN</b>"]
    IRON_METABOLISM["IRON METABOLISM"]
    TRANSFERRIN -->|"involved in"| IRON_METABOLISM
    TFR1["TFR1"]
    TRANSFERRIN -->|"binds"| TFR1
    TFR1["TFR1"]
    TFR1 -->|"binds"| TRANSFERRIN
    TRANSFERRIN_RECEPTOR_1["TRANSFERRIN RECEPTOR 1"]
    TRANSFERRIN_RECEPTOR_1 -->|"binds to"| TRANSFERRIN
    TRANSFERRIN_RECEPTOR_2["TRANSFERRIN RECEPTOR 2"]
    TRANSFERRIN_RECEPTOR_2 -->|"binds to"| TRANSFERRIN
    TFR2["TFR2"]
    TFR2 -->|"binds"| TRANSFERRIN
    TXB2["TXB2"]
    TXB2 -->|"associated with"| TRANSFERRIN
    ISCHEMIA["ISCHEMIA"]
    TRANSFERRIN -->|"associated with"| ISCHEMIA
    FERROPORTIN["FERROPORTIN"]
    TRANSFERRIN -->|"associated with"| FERROPORTIN
    MACROPHAGES["MACROPHAGES"]
    TRANSFERRIN -->|"associated with"| MACROPHAGES
    HEPATOCYTES["HEPATOCYTES"]
    TRANSFERRIN -->|"associated with"| HEPATOCYTES
    ferroptosis["ferroptosis"]
    TRANSFERRIN -->|"associated with"| ferroptosis
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"]
    TRANSFERRIN -->|"activates"| BLOOD_BRAIN_BARRIER
    Proteins["Proteins"]
    TRANSFERRIN -->|"activates"| Proteins
    Proteins["Proteins"]
    TRANSFERRIN -->|"regulates"| Proteins
    Genes["Genes"]
    TRANSFERRIN -->|"interacts with"| Genes
    ST6GAL1["ST6GAL1"]
    TRANSFERRIN -->|"interacts with"| ST6GAL1
    FUT8["FUT8"]
    TRANSFERRIN -->|"interacts with"| FUT8
    IGF2R["IGF2R"]
    TRANSFERRIN -->|"interacts with"| IGF2R
    SORTILIN["SORTILIN"]
    TRANSFERRIN -->|"interacts with"| SORTILIN
    INSULIN["INSULIN"]
    TRANSFERRIN -->|"interacts with"| INSULIN
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"]
    TRANSFERRIN -->|"associated with"| BLOOD_BRAIN_BARRIER
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"]
    TRANSFERRIN -->|"interacts with"| BLOOD_BRAIN_BARRIER
    cancer["cancer"]
    TRANSFERRIN -->|"associated with"| cancer
    FERROPORTIN["FERROPORTIN"]
    TRANSFERRIN -->|"interacts with"| FERROPORTIN
    HEPCIDIN["HEPCIDIN"]
    TRANSFERRIN -->|"interacts with"| HEPCIDIN
    ferroptosis["ferroptosis"]
    TRANSFERRIN -->|"activates"| ferroptosis
    GLUTAMATE["GLUTAMATE"]
    TRANSFERRIN -->|"activates"| GLUTAMATE
    CATALASE["CATALASE"]
    TRANSFERRIN -->|"associated with"| CATALASE
    FERROPORTIN["FERROPORTIN"]
    TRANSFERRIN -->|"regulates"| FERROPORTIN

Outgoing (61)

TargetRelationTypeStr
IRON METABOLISMinvolved_inentity0.95
NEURONtransportscell_type0.90
ISCHEMIAassociated_withdisease0.50
FERROPORTINassociated_withprotein0.50
MACROPHAGESassociated_withconcept0.50

Incoming (79)

SourceRelationTypeStr
TRANSFERRIN RECEPTOR 1binds_toentity0.95
TRANSFERRIN RECEPTOR 2binds_toentity0.90
TXB2associated_withcompound0.85
TFR1associated_withgene0.50
DMT1associated_withgene0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Magnetosonic-Triggered Transferrin Receptor Clustering 0.470 neurodegeneration Blood-brain barrier transport mechanisms

Mentioning Analyses (1)

Scientific analyses that reference this entity

Blood-brain barrier transport mechanisms for antibody therapeutics

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.566

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease. [PMID:40425446] Sehlin D, Hultqvist G, Michno W, Aguilar J Prev Alzheimers Dis 2025 1
Effect of ferroptosis on chronic cerebral hypoperfusion in vascular dementia. [PMID:37709116] Fu P, Chen Y, Wu M, Bao B, Yin X, Chen Z Exp Neurol 2023 1
On Iron Metabolism and Its Regulation. [PMID:33925597] Vogt AS, Arsiwala T, Mohsen M, Vogel M, Int J Mol Sci 2021 1
Transferrin Receptor Is a Specific Ferroptosis Marker. [PMID:32160546] Feng H, Schorpp K, Jin J, Yozwiak CE, Ho Cell Rep 2020 1
Transferrin and transferrin receptors update. [PMID:29969719] Kawabata H Free Radic Biol Med 2019 1
A proimmunotoxin nanodrug targeting AIDS-associated non-Hodgkin lymphoma. [PMID:41592623] Chen S, Qi T, Peng H, Kimura E, Zhang X J Control Release 2026 0
Time- and dose-dependent effects of bacterial infection on iron metabolism, infl [PMID:41619877] Lu Y, Zhang Y, Niu C Comp Biochem Physiol A Mol Int 2026 0
Ayanin combats against barium sulphate nanoparticles induced hepatotoxicity via [PMID:41666660] Zhu D, Lu Y, Jamil S, Ashfaq H, Al-Emam J Trace Elem Med Biol 2026 0
Role of iron and TfR1 in the application of high‑dose ascorbate against pancreat [PMID:41789665] Piotrowsky A, Leischner C, Schmieder H, Oncol Rep 2026 0
Brain and Liver Dual-Targeting Oridonin Nanoparticles to Enhance Aβ Clearance fo [PMID:41944296] Gong W, Hui W, Qiao S, Ji Q, Liu M et al Adv Sci (Weinh) 2026 0
Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in [PMID:41947413] Palsa K, Sahu AP, Rye DB, Trotti LM, Elc Ann Neurol 2026 0
Pulmonary neuroendocrine cell-derived exosomes regulate iron homeostasis and oxi [PMID:41950316] Thakur A, Zhang K, Chen J, Mei S, Chen J Sci Adv 2026 0
O-GlcNAc Modification Orchestrates HUWE1-Mediated Ubiquitination of TfR1 to Regu [PMID:41962599] Zhang H, Li M, Zhang J, Sun Q, Jin X et Free Radic Biol Med 2026 0
Protective Role of Polydatin Against Vancomycin-Induced Lung Toxicity via Oxidat [PMID:41963266] Aygörmez S, Küçükler S, Çomaklı S, Şimşe J Appl Toxicol 2026 0
Yangxin granules exert cardioprotective effects against acute myocardial infarct [PMID:41868900] Huo G, Zhou Y, Wu Z, Sun S, Zhu G, Cheng American journal of translatio 2026 0
Conformational dynamics study of TfR1 upon transferrin binding via NMA and MD si [PMID:41921418] Zemmouche M, Falque G, Cadet F, Gardebie Journal of molecular graphics 2026 0
[Effects of acupuncture on ferroptosis and ferritinophagy in cerebral ischemia-r [PMID:41839581] Wang YF, Dong YS Zhen ci yan jiu = Acupuncture 2026 0
The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibit [PMID:41854751] Nan K, Zhang L, Zhao Y, Yin S, Peng Y, H Apoptosis : an international j 2026 0
The Role of Artemisinin and its Derivatives in Cancer Therapy via Ferroptosis: A [PMID:41833023] Osmanlioglu Dag SR, Tatli Cankaya II, Oz Anti-cancer agents in medicina 2026 0
Raccoon eyes. [PMID:35789012] Ning J Journal of paediatrics and chi 2023 0