cell_type

B Cell

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about B Cell: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

477Connections

1Hypotheses

1Analyses

30Outgoing

50Incoming

No summary available yet. View on Wiki →

🧫 Cell Type Info

Cell Type	B Cell
Related Genes	Igg, GLAUCOMA, PER, MICROGLIA, EXOSOMES, PHAGOCYTOSIS
Linked Hypotheses	30 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    B_Cell["B Cell"] -->|"expressed in"| ST6Gal1["ST6Gal1"]
    style ST6Gal1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    B_Cell["B Cell"] -->|"associated"| Neuromyelitis_Optica_Spectrum_["Neuromyelitis Optica Spectrum Disorder"]
    style Neuromyelitis_Optica_Spectrum_ fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    TCR["TCR"] -->|"expressed in"| B_Cell["B Cell"]
    style TCR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    CD40["CD40"] -->|"expressed in"| B_Cell["B Cell"]
    style CD40 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    CANCER["CANCER"] -->|"expressed in"| B_Cell["B Cell"]
    style CANCER fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    AQP4["AQP4"] -->|"expressed in"| B_Cell["B Cell"]
    style AQP4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    COMPLEMENT["COMPLEMENT"] -->|"expressed in"| B_Cell["B Cell"]
    style COMPLEMENT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style B_Cell fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (74)

Target	Relation	Type	Str
ST6Gal1	expressed_in	enzyme	0.90
Neuromyelitis Optica Spectrum Disorder	contributes_to	disease	0.90
Igg	expressed_in	protein	0.90
Aqp4-Igg	associated_with	biomarker	0.88
Neuromyelitis Optica Spectrum Disorder	associated_with	disease	0.80
ST6GAL1	associated_with	concept	0.50
B CELLS	associated_with	concept	0.50
FUT8	associated_with	concept	0.50
ST6GAL1	activates	concept	0.50
FUT8	activates	concept	0.50
GENE EXPRESSION	expressed_in	concept	0.50
B CELLS	expressed_in	concept	0.50
DNA DAMAGE	regulates	concept	0.50
Microrna	regulates	pathway	0.50
Dna Damage Response	regulates	pathway	0.50
Microrna	interacts_with	pathway	0.50
Proteins	interacts_with	protein	0.50
B CELLS	interacts_with	concept	0.50
Immunotherapy	activates	process	0.50
B CELLS	activates	concept	0.50
MACROPHAGES	activates	concept	0.50
T CELLS	activates	concept	0.50
STEM CELLS	activates	concept	0.50
NEUTROPHILS	activates	concept	0.50
DENDRITIC CELLS	activates	concept	0.50
MONOCYTE	activates	concept	0.50
MONOCYTES	activates	concept	0.50
Spinal Cord	expressed_in	brain_region	0.50
Brainstem	expressed_in	brain_region	0.50
Cortex	expressed_in	brain_region	0.50

Incoming (403)

Source	Relation	Type	Str
Inebilizumab	downregulates	drug	0.90
TCR	activates	gene	0.60
AQP4	inhibits	gene	0.60
CD19	inhibits	gene	0.60
ASTROCYTE	therapeutic_target	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
COMPLEMENT	inhibits	gene	0.60
EMD	activates	gene	0.60
MAX	activates	gene	0.60
AQP4	activates	gene	0.60
JUN	transports	gene	0.60
FUT8	activates	gene	0.60
ST6GAL1	transports	gene	0.60
CASPASE8	inhibits	gene	0.60
EHMT2	inhibits	gene	0.60
BAX	inhibits	gene	0.60
CASPASE3	inhibits	gene	0.60
APOPTOSIS	activates	gene	0.60
FOXO1	inhibits	gene	0.60
JUN	inhibits	gene	0.60
PARP1	inhibits	gene	0.60
IL-10	inhibits	gene	0.60
EGR2	inhibits	gene	0.60
SIRT6	inhibits	gene	0.60
NAD	activates	gene	0.60
CD38	inhibits	gene	0.60
JUN	therapeutic_target	gene	0.60
IRF4	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
DNA	regulates	gene	0.60
RNA	regulates	gene	0.60
FOXO3	protects_against	gene	0.60
AMPK	protects_against	gene	0.60
SIRT1	protects_against	gene	0.60
OCLN	activates	gene	0.60
LC3B	protects_against	gene	0.60
AUTOPHAGY	protects_against	gene	0.60
ABL1	activates	gene	0.60
NTRK3	activates	gene	0.60
PTK2B	activates	gene	0.60
PDGFRB	activates	gene	0.60
EPOR	activates	gene	0.60
TYK2	activates	gene	0.60
CRLF2	activates	gene	0.60
FLT3	activates	gene	0.60
JAK2	activates	gene	0.60
IL7R	activates	gene	0.60
ABL2	activates	gene	0.60
TSLP	activates	gene	0.60
CSF1R	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ	0.612	neuroinflammation	How do B cells mechanistically orchestra

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do B cells mechanistically orchestrate tolerance to AQP4 and prevent autoimm

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.612

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

B Cell

Understanding Entity Pages

Wiki Pages (20)

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Neuroinflammation Across AD, PD, ALS, FTD, and HD

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Endocannabinoid System Dysfunction Hypothesis in Parkinson's Disease

Neuroinflammation in Amyotrophic Lateral Sclerosis

Blood-Brain Barrier Breakdown in Neurodegeneration

CR1 Gene — Complement Component 1q Receptor