concept

IL-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1626Connections

3Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	IL-1
Key Genes/Proteins	NLRP3, NF-κB, IL-17, NF-KB
Related Diseases	Cognitive Impairment, Mitochondrial dysfunction-associated senescence, Atherosclerosis, Inflammatory Senescence-Associated Secretory Phenotype, Senescence-associated secretory phenotype

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    IL_1["IL-1"]
    style IL_1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    IL_1 -->|"contributes to"| Atherosclerosis["Atherosclerosis"]
    IL_1 -->|"mediates"| Inflammatory_Senescence_Associ(Inflammatory Senescence-Associated Secretory Phenotype)
    IL_1 -->|"activates"| Ms["Ms"]
    IL_1 -->|"activates"| Tumor["Tumor"]
    IL_1 -->|"activates"| Inflammation["Inflammation"]
    IL_1 -->|"activates"| Alzheimer["Alzheimer"]
    IL_1 -->|"activates"| Aging["Aging"]
    IL_1 -->|"activates"| Phagocytosis["Phagocytosis"]
    IL_1 -->|"activates"| OCLN([OCLN])
    IL_1 -->|"activates"| MLCK([MLCK])
    NLRP3([NLRP3]) -->|"activates"| IL_1
    IL_17([IL-17]) -->|"co_expressed_with"| IL_1
    DISEASE_ASSOCIATED_MICROGLIA([DISEASE-ASSOCIATED MICROGLIA]) -->|"activates"| IL_1
    TNFR1([TNFR1]) -->|"activates"| IL_1
    AND([AND]) -->|"activates"| IL_1
    MICROGLIA([MICROGLIA]) -->|"activates"| IL_1
    MYELIN([MYELIN]) -->|"activates"| IL_1
    CYTOKINES([CYTOKINES]) -->|"activates"| IL_1
    NEURODEGENERATIVE_DISEASES([NEURODEGENERATIVE DISEASES]) -->|"activates"| IL_1
    PHAGOCYTOSIS([PHAGOCYTOSIS]) -->|"activates"| IL_1

Outgoing (800)

Target	Relation	Type	Str
Cognitive Impairment	associated_with	phenotype	0.85
Systemic Inflammation	mediates	process	0.85
Atherosclerosis	contributes_to	disease	0.80
Inflammatory Senescence-Associated Secretory Phenotype	mediates	phenotype	0.80
MICROGLIA	upregulates	cell_type	0.80
Senescence-associated secretory phenotype	regulates	phenotype	0.80
Ms	activates	disease	0.65
Als	associated_with	disease	0.65
Tumor	activates	disease	0.65
Aging	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Aging	activates	disease	0.65
Senescence	activates	disease	0.65
Tumor	associated_with	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Autoimmune	activates	disease	0.65
ALS	activates	disease	0.65
Inflammation	interacts_with	disease	0.65
Ischemia	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ferroptosis	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Stroke	activates	disease	0.65
Diabetes	activates	disease	0.65
Pyroptosis	associated_with	disease	0.65
Als	activates	disease	0.65
Parkinson	activates	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Fibrosis	activates	disease	0.65
Ferroptosis	activates	disease	0.65
Cancer	activates	disease	0.65
Obesity	activates	disease	0.65
Dementia	activates	disease	0.65
Alzheimer	contributes_to	disease	0.65
Als	contributes_to	disease	0.65
Dementia	contributes_to	disease	0.65
Neurodegeneration	contributes_to	disease	0.65
Neuroinflammation	contributes_to	disease	0.65
Stroke	inhibits	disease	0.65
Pyroptosis	inhibits	disease	0.65
Alzheimer	therapeutic_target	disease	0.65

Incoming (826)

Source	Relation	Type	Str
NLRP3	activates	protein	0.90
NF-κB	upregulates	protein	0.85
Mitochondrial dysfunction-associated senescence	inhibits	phenotype	0.85
IL-17	co_expressed_with	protein	0.80
ALZHEIMER'S DISEASE	associated_with	disease	0.74
NF-KB	associated_with	protein	0.66
ALS	associated_with	disease	0.66
DISEASE-ASSOCIATED MICROGLIA	activates	gene	0.60
TNFR1	activates	gene	0.60
AND	activates	gene	0.60
IL-10	associated_with	gene	0.60
MICROGLIA	activates	gene	0.60
MYELIN	activates	gene	0.60
CYTOKINES	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
IL-10	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
APOE	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AGING	activates	gene	0.60
NAD	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
ALPK1	activates	gene	0.60
TRAF2	activates	gene	0.60
LAMP1	associated_with	gene	0.60
PPAR	activates	gene	0.60
CLDN1	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
C1Q	activates	gene	0.60
PSME3	therapeutic_target	gene	0.60
BAD	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
LAMP2	therapeutic_target	gene	0.60
BID	therapeutic_target	gene	0.60
TLR2	associated_with	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
SPR	inhibits	gene	0.60
PFKFB3	inhibits	gene	0.60
LDHA	inhibits	gene	0.60
HK2	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
STROKE	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
NRF2	activates	gene	0.60
STROKE	activates	gene	0.60
CX3CR1	activates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral	0.601	neuroinflammation	How do B cells mechanistically orchestra
TNF-α/IL-1β-Cx43 Hemichannel Axis as Upstream Link Between S	0.548	cell biology	What is the relative contribution of con
TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Functio	0.499	neuroinflammation	Why do TAM receptors protect against neu

Mentioning Analyses (1)

Scientific analyses that reference this entity

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.521

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IL-1

Understanding Entity Pages

Wiki Pages (20)

Corticobasal Syndrome (CBS)

Paraventricular Hypothalamic Nucleus (PVN) Neurons

Glia-Neuron Crosstalk in Alzheimer's Disease

Gut-Brain Axis in Neurodegeneration

Wallerian Degeneration

Neuroinflammation in Amyotrophic Lateral Sclerosis

Longevity and Rejuvenation Therapies Landscape

UBE2V1 Gene (UEV-1)

Progressive Supranuclear Palsy

Neuroinflammation Microglia

NLRP3 Inflammasome Activation Pathway in Neurodegeneration

Complement-Mediated Synapse Loss

Neuroinflammation in Alzheimer's Disease

NIH Drug Repurposing Program for Neurodegenerative Diseases

TLR5-Mediated Microglial Neuroinflammation Hypothesis

IL1RAP — Interleukin-1 receptor accessory protein