protein

Il-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Il-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1626Connections

3Hypotheses

1Analyses

39Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	Il-1
Associated Diseases	Senescence
Interactions	REL, IL-17, COMPLEMENT, ASTROCYTES, GLAUCOMA, CD38
KG Connections	369 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Il_1["Il-1"] -->|"expressed in"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Il_1["Il-1"] -->|"expressed in"| Parkinson["Parkinson"]
    style Parkinson fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Il_1["Il-1"] -->|"therapeutic target"| Atherosclerosis["Atherosclerosis"]
    style Atherosclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Il_1["Il-1"] -->|"activates"| Glioblastoma["Glioblastoma"]
    style Glioblastoma fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Il_1["Il-1"] -->|"associated"| Senescence["Senescence"]
    style Senescence fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Il_1["Il-1"] -->|"regulates"| Aging["Aging"]
    style Aging fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Il_1["Il-1"] -->|"expressed in"| Dementia["Dementia"]
    style Dementia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    REL["REL"] -->|"activates"| Il_1["Il-1"]
    style REL fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CERS2["CERS2"] -->|"associated"| Il_1["Il-1"]
    style CERS2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    MIRO1["MIRO1"] -->|"associated"| Il_1["Il-1"]
    style MIRO1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    RNA["RNA"] -->|"regulates"| Il_1["Il-1"]
    style RNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    TGFB1["TGFB1"] -->|"regulates"| Il_1["Il-1"]
    style TGFB1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Il_1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (800)

Target	Relation	Type	Str
Cancer	expressed_in	disease	0.60
Parkinson	expressed_in	disease	0.60
Atherosclerosis	therapeutic_target	disease	0.60
Glioblastoma	activates	disease	0.60
Senescence	associated_with	disease	0.60
Cancer	therapeutic_target	disease	0.60
Aging	regulates	disease	0.60
Dementia	expressed_in	disease	0.60
Vascular Dementia	expressed_in	disease	0.60
Als	transports	disease	0.60
Obesity	regulates	disease	0.60
Prion Disease	expressed_in	disease	0.60
Neurodegeneration	expressed_in	disease	0.60
Anxiety	activates	disease	0.60
Aging	inhibits	disease	0.60
Anxiety	inhibits	disease	0.60
Diabetes	protects_against	disease	0.60
Neuroinflammation	protects_against	disease	0.60
Neurodegeneration	protects_against	disease	0.60
Cancer	interacts_with	disease	0.60
Immune Response	regulates	pathway	0.55
Immune Response	expressed_in	pathway	0.55
Innate Immunity	inhibits	pathway	0.55
Glycolysis	activates	pathway	0.55
Toll-Like Receptor	associated_with	pathway	0.55
Immune Response	interacts_with	pathway	0.55
Glycolysis	inhibits	pathway	0.55
Blood-Brain Barrier	associated_with	pathway	0.55
Oxidative Stress	associated_with	pathway	0.55
Jak-Stat	activates	pathway	0.55
Synaptic Plasticity	activates	pathway	0.55
Mapk	therapeutic_target	pathway	0.55
Toll-Like Receptor	therapeutic_target	pathway	0.55
Calcium Signaling	associated_with	pathway	0.55
Cholesterol	therapeutic_target	pathway	0.55
Lipid Metabolism	regulates	pathway	0.55
Apoptosis	contributes_to	pathway	0.55
Oxidative Stress	therapeutic_target	pathway	0.55
Immune Response	inhibits	pathway	0.55

Incoming (826)

Source	Relation	Type	Str
REL	activates	gene	0.60
CERS2	associated_with	gene	0.60
MIRO1	associated_with	gene	0.60
RNA	regulates	gene	0.60
TGFB1	regulates	gene	0.60
FOXP3	regulates	gene	0.60
CD4	regulates	gene	0.60
IL-17	inhibits	gene	0.60
COMPLEMENT	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
GLAUCOMA	activates	gene	0.60
CD38	activates	gene	0.60
PARP1	inhibits	gene	0.60
NAD	inhibits	gene	0.60
NAMPT	inhibits	gene	0.60
SIRT6	inhibits	gene	0.60
EGR2	activates	gene	0.60
CD68	inhibits	gene	0.60
FERROPTOSIS	therapeutic_target	gene	0.60
TFRC	therapeutic_target	gene	0.60
IL-17	associated_with	gene	0.60
PPP1CB	therapeutic_target	gene	0.60
PKM2	inhibits	gene	0.60
ANXA1	therapeutic_target	gene	0.60
NEURON	therapeutic_target	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
CD163	activates	gene	0.60
CD36	activates	gene	0.60
CD68	activates	gene	0.60
IL-18	expressed_in	gene	0.60
CD8	expressed_in	gene	0.60
CD4	expressed_in	gene	0.60
STAR	expressed_in	gene	0.60
TCR	expressed_in	gene	0.60
AMYLOID-BETA	activates	gene	0.60
EXERCISE	activates	gene	0.60
BDNF	activates	gene	0.60
NEURON	expressed_in	gene	0.60
PARKINSON	expressed_in	gene	0.60
CXCL1	inhibits	gene	0.60
AXL	therapeutic_target	gene	0.60
MMP12	inhibits	gene	0.60
PRDX1	activates	gene	0.60
P38	activates	gene	0.60
AKT	activates	gene	0.60
ERK1/2	activates	gene	0.60
GSDMD	activates	gene	0.60
TREM2	activates	gene	0.60
NEURON	activates	gene	0.60
POLE	activates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral	0.601	neuroinflammation	How do B cells mechanistically orchestra
TNF-α/IL-1β-Cx43 Hemichannel Axis as Upstream Link Between S	0.548	cell biology	What is the relative contribution of con
TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Functio	0.499	neuroinflammation	Why do TAM receptors protect against neu

Mentioning Analyses (1)

Scientific analyses that reference this entity

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.521

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Il-1

Understanding Entity Pages

Wiki Pages (20)

Corticobasal Syndrome (CBS)

Paraventricular Hypothalamic Nucleus (PVN) Neurons

Glia-Neuron Crosstalk in Alzheimer's Disease

Gut-Brain Axis in Neurodegeneration

Wallerian Degeneration

Neuroinflammation in Amyotrophic Lateral Sclerosis

Longevity and Rejuvenation Therapies Landscape

UBE2V1 Gene (UEV-1)

Progressive Supranuclear Palsy

Neuroinflammation Microglia

NLRP3 Inflammasome Activation Pathway in Neurodegeneration

Complement-Mediated Synapse Loss

Neuroinflammation in Alzheimer's Disease

NIH Drug Repurposing Program for Neurodegenerative Diseases

TLR5-Mediated Microglial Neuroinflammation Hypothesis

IL1RAP — Interleukin-1 receptor accessory protein