protein

MEKK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MEKK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

5Outgoing

0Incoming

0Experiments

0Debates

Summary

MEK Kinase 2 - MAP3K that activates ERK and JNK pathways with roles in neurodevelopment and neurodegeneration

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	MEKK2
Full Name	MEKK2 (MEK Kinase 2)
Aliases	MEK Kinase 2
Protein Family	MAP3K (MAP Kinase Kinase Kinase) family
Protein Type	Kinase
Function	is a serine/threonine protein kinase that functions as a mitogen-activated protein kinase kinase kinase (MAP3K) in the MAPK signaling cascades.
Primary Expression	Ubiquitous; high in brain, heart, skeletal muscle
Molecular Weight	71.7 kDa
Amino Acids	619 aa
Pathways	MAPK signaling, MAPK pathway, MAPK
UniProt ID	Q9Y252
GeneCards	MEKK2
Human Protein Atlas	MEKK2
Activation Loop	ContainsThr-249 and Ser-252, which are phosphorylated for activation
ATP-Binding Site	Binds ATP and ATP-competitive inhibitors
Associated Diseases	Alzheimer's disease, Parkinson's disease, ALS
Interactions	MAPK
KG Connections	5 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MEKK2 — AlphaFold Q9Y252 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MEKK2 Protein

protein · 2107 words

→

Pathway Diagram

flowchart TD
    MEKK2(["MEKK2"])
    Cardiovascular["Cardiovascular"]
    AND(["AND"])
    MAPK(["MAPK"])
    Mapk["Mapk"]
    Endothelial_Cell["Endothelial Cell"]
    MAPK_SIGNALING("MAPK SIGNALING")
    neurodegeneration["neurodegeneration"]

    MEKK2 -->|"regulates"| Cardiovascular
    MEKK2 -->|"regulates"| AND
    MEKK2 -->|"activates"| MAPK
    MEKK2 -->|"activates"| Mapk
    MEKK2 -->|"expressed in"| Endothelial_Cell
    MEKK2 -->|"activates"| MAPK_SIGNALING
    MEKK2 -->|"implicated in"| neurodegeneration

    style MEKK2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (5)

Target	Relation	Type	Str
Cardiovascular	regulates	disease	0.65
MAPK	activates	gene	0.60
Mapk	activates	pathway	0.60
Endothelial Cell	expressed_in	cell_type	0.55
MAPK SIGNALING	activates	concept	0.50

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MEKK2 in their description or question text

No additional research found