cell_type

Endothelial Cell

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Endothelial Cell: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

470Connections

1Hypotheses

0Analyses

41Outgoing

50Incoming

Summary

Endothelial Cell is a cell type relevant to neurodegeneration research. Key relationships include: expressed in, associated with. Connected to 161 entities in the SciDEX knowledge graph.

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🧫 Cell Type Info

Cell Type	Endothelial Cell
Related Genes	STING, NTN1, ALZHEIMER'S DISEASE, NEURON, REST, CD2AP
Linked Hypotheses	98 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| Endothelial_Cell["Endothelial Cell"]
    NEURON["NEURON"] -->|"expressed in"| Endothelial_Cell["Endothelial Cell"]
    REST["REST"] -->|"expressed in"| Endothelial_Cell["Endothelial Cell"]
    CD2AP["CD2AP"] -->|"expressed in"| Endothelial_Cell["Endothelial Cell"]
    style Endothelial_Cell fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (53)

Target	Relation	Type	Str
NTN1	expressed_in	gene	0.85
Blood-Brain Barrier Function	involved_in	process	0.85
Myofibroblast	associated_with	cell_type	0.75
ENDOTHELIAL	activates	concept	0.50
AXON	associated_with	concept	0.50
ENDOTHELIAL	associated_with	concept	0.50
AXON REGENERATION	associated_with	concept	0.50
ENDOTHELIAL CELLS	associated_with	concept	0.50
ENDOTHELIAL	interacts_with	concept	0.50
ENDOTHELIAL CELLS	interacts_with	concept	0.50
CENTRAL NERVOUS SYSTEM	interacts_with	concept	0.50
disease	activates	disease	0.50
TJP1	activates	concept	0.50
ENDOTHELIAL CELLS	activates	concept	0.50
ENDOTHELIAL	inhibits	concept	0.50
ENDOTHELIAL	causes	concept	0.50
ENDOTHELIAL CELLS	causes	concept	0.50
ENDOTHELIAL	regulates	concept	0.50
ENDOTHELIAL CELLS	regulates	concept	0.50
CELL PROLIFERATION	activates	concept	0.50
IPSC	activates	concept	0.50
BLOOD-BRAIN BARRIER DYSFUNCTION	activates	concept	0.50
CELL DEATH	regulates	concept	0.50
ISCHEMIC	inhibits	concept	0.50
ISCHEMIC STROKE	inhibits	concept	0.50
ENDOTHELIAL CELLS	inhibits	concept	0.50
ENDOTHELIAL	protects_against	concept	0.50
ENDOTHELIAL	expressed_in	concept	0.50
ENDOTHELIAL CELLS	expressed_in	concept	0.50
ISCHEMIC	regulates	concept	0.50
ISCHEMIC STROKE	regulates	concept	0.50
STEM CELLS	regulates	concept	0.50
EXTRACELLULAR VESICLES	regulates	concept	0.50
Proteins	interacts_with	protein	0.50
STEM CELLS	interacts_with	concept	0.50
EXTRACELLULAR VESICLES	interacts_with	concept	0.50
ISCHEMIC	associated_with	concept	0.50
RESVERATROL	regulates	concept	0.50
BRAIN INFLAMMATION	associated_with	concept	0.50
Bipolar	interacts_with	disease	0.50
STEM CELLS	activates	concept	0.50

Incoming (417)

Source	Relation	Type	Str
Brain Arteriovenous Malformations	causes	disease	0.92
STING	expressed_in	protein	0.90
Circadian Clock	expressed_in	pathway	0.90
Ethanol	modulates	compound	0.80
ALZHEIMER'S DISEASE	expressed_in	gene	0.55
NEURON	expressed_in	gene	0.55
REST	expressed_in	gene	0.55
CD2AP	expressed_in	gene	0.55
ALZHEIMER	expressed_in	gene	0.55
REELIN	expressed_in	gene	0.55
AXON REGENERATION	expressed_in	gene	0.55
AXON	expressed_in	gene	0.55
AKT	expressed_in	gene	0.55
JUN	expressed_in	gene	0.55
NTN1	expressed_in	gene	0.55
EXOSOMES	expressed_in	gene	0.55
TJP1	expressed_in	gene	0.55
ROS	expressed_in	gene	0.55
STROKE	expressed_in	gene	0.55
CAV1	expressed_in	gene	0.55
CLDN5	expressed_in	gene	0.55
UBIQUITIN	expressed_in	gene	0.55
OCLN	expressed_in	gene	0.55
HIF1A	expressed_in	gene	0.55
BECN1	expressed_in	gene	0.55
AUTOPHAGY	expressed_in	gene	0.55
XBP1	expressed_in	gene	0.55
ATF4	expressed_in	gene	0.55
HSPA5	expressed_in	gene	0.55
CXCL2	expressed_in	gene	0.55
IL23A	expressed_in	gene	0.55
PERK	expressed_in	gene	0.55
PPP1R15A	expressed_in	gene	0.55
DDIT3	expressed_in	gene	0.55
IL12B	expressed_in	gene	0.55
CYTOKINES	expressed_in	gene	0.55
IRE1	expressed_in	gene	0.55
IL6	expressed_in	gene	0.55
CXCL1	expressed_in	gene	0.55
ASTROCYTES	expressed_in	gene	0.55
PIEZO1	expressed_in	gene	0.55
MICROGLIA	expressed_in	gene	0.55
EXERCISE	expressed_in	gene	0.55
TRPA1	expressed_in	gene	0.55
TRPV4	expressed_in	gene	0.55
RUNX2	expressed_in	gene	0.55
GENES	expressed_in	gene	0.55
VEGFB	expressed_in	gene	0.55
BMP2	expressed_in	gene	0.55
PDGFRB	expressed_in	gene	0.55

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Synthetic Biology BBB Endothelial Cell Reprogramming	0.565	neurodegeneration	Blood-brain barrier transport mechanisms

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (8)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Cathepsin S is a novel target for age-related dry eye. [PMID:34910926]	["Yu Z", "Li J", "Govindarajan G", "Hamm	Experimental eye research	2022
Intrinsic functional neuron-type selectivity of transcranial focused ultrasound [PMID:33947867]	["Yu K", "Niu X", "Krook-Magnuson E", "H	Nature communications	2021
NK cells for cancer immunotherapy. [PMID:31907401]	["Shimasaki N", "Jain A", "Campana D"]	Nature reviews. Drug discovery	2020
Potent and specific MTH1 inhibitors targeting gastric cancer. [PMID:31164636]	["Zhou W", "Ma L", "Yang J", "Qiao H", "	Cell death & disease	2019
Clinical factors associated with worse quality-of-life scores in United States t [PMID:30898373]	["Goswami S", "Peipert B", "Mongelli M",	Surgery	2019
Arabidopsis Duodecuple Mutant of PYL ABA Receptors Reveals PYL Repression of ABA [PMID:29898403]	["Zhao Y", "Zhang Z", "Gao J", "Wang P",	Cell reports	2018
Cell transplantation therapy for spinal cord injury. [PMID:28440805]	["Assinck P", "Duncan G", "Hilton B", "P	Nature neuroscience	2017
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. [PMID:22343897]	["Ichimura A", "Hirasawa A", "Poulain-Go	Nature	2012

Endothelial Cell

Understanding Entity Pages

Summary

Wiki Pages (20)

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CNTN4 — Contactin 4

VEGF/Angiogenesis Pathway in Neurodegeneration

Blood-Brain Barrier Biology and Crossing Strategies

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