protein

NCSTNPROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about NCSTNPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Nicastrin is a type I transmembrane glycoprotein of ~130 kDa that serves as the substrate receptor of the γ-secretase complex<sup>[1]</sup>.

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🔬 Protein Info

Gene Symbol	NCSTNPROTEIN
Protein Type	Protease
Function	is an essential subunit of the γ-secretase complex that cleaves amyloid precursor protein (APP) and Notch receptors.
Subcellular Localization	** \| Plasma membrane, endosomes, Golgi \|
Molecular Weight	130 kDa
Amino Acids	709 aa
GeneCards	NCSTNPROTEIN
Human Protein Atlas	NCSTNPROTEIN
DAP domain	Peptidase-like domain that recognizes free N-termini of γ-secretase substrates
Lid domain	Covers the active site region; opens to admit substrates
Single transmembrane helix	Anchors nicastrin in the membrane; interacts with APH-1
N-glycosylation	16 potential N-glycosylation sites; heavy glycosylation critical for maturation and surface expression
N-terminus recognition	Nicastrin's Glu333 (DAP domain) recognizes the free N-terminal stub of substrates after ectodomain shedding (by α- or β-secretase)
Size filter	Ectodomain acts as a molecular ruler — only substrates with short (<50 aa) residual ectodomains can access the presenilin active site
No enzymatic activity	Despite structural similarity to aminopeptidases, nicastrin has no catalytic activity
Associated Diseases	AD, Als, Alzheimer, Alzheimer's disease, AMI
Interactions	A2M, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APH1B, APOE
KG Connections	189 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Nicastrin (NCSTN Protein)

protein · 863 words

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Pathway Diagram

graph TD
    NCSTNPROTEIN["NCSTNPROTEIN"]
    neurodegeneration["neurodegeneration"]
    NCSTNPROTEIN -->|"implicated_in"| neurodegeneration
    style NCSTNPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

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Mentioning Analyses (0)

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Experiments (0)

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Related Papers (0)

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Related Research

Hypotheses and analyses mentioning NCSTNPROTEIN in their description or question text

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