gene

A2M

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about A2M: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

107Connections

0Hypotheses

0Analyses

50Outgoing

36Incoming

Summary

A2M is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, implicated in. Associated with AD, ALS, AMI. Connected to 83 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	A2M
Chromosome	12p13.31 (human)
Protein Family	α2-macroglobulin family
Function	The protein possesses a unique "trap" mechanism
Molecular Weight	~720 kDa (tetramer)
Amino Acids	1450 amino acids
UniProt ID	P01023
NCBI Gene ID	2
GeneCards	A2M
Human Protein Atlas	A2M
Protein	Alpha-2-macroglobulin
Synonyms	A2MP, alpha-2-M, α2M
Protein Length	1450 amino acids
Approach	Development Stage
A2M enhancement	Preclinical
Associated Diseases	AD, AMI, Als, Alzheimer, Alzheimer's disease, Depression
Interactions	DHCR24, HMGCR, MAPT, PARP1, PEN2, PSEN1
KG Connections	107 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: A2M — AlphaFold P01023 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    A2M["A2M"] -->|"interacts"| Alzheimer["Alzheimer"]
    A2M["A2M"] -->|"interacts"| Tumor["Tumor"]
    A2M["A2M"] -->|"interacts"| Als["Als"]
    A2M["A2M"] -->|"associated"| Als_1["Als"]
    A2M["A2M"] -->|"associated"| Ms["Ms"]
    A2M["A2M"] -->|"associated"| Depression["Depression"]
    Hsv_1["Hsv-1"] -->|"binds"| A2M["A2M"]
    NCSTN["NCSTN"] -->|"interacts"| A2M["A2M"]
    FAS["FAS"] -->|"interacts"| A2M["A2M"]
    TNF["TNF"] -->|"interacts"| A2M["A2M"]
    style A2M fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (71)

Target	Relation	Type	Str
Alzheimer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
DHCR24	interacts_with	gene	0.60
HMGCR	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
PEN2	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
DAPK1	interacts_with	gene	0.60
HSPG2	interacts_with	gene	0.60
IL1B	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
EIF2AK2	interacts_with	gene	0.60
AQP4	associated_with	gene	0.60
TNF	associated_with	gene	0.60
P2RX7	associated_with	gene	0.60
ISG15	associated_with	gene	0.60
STAT1	associated_with	gene	0.60
USP18	associated_with	gene	0.60
CXCL12	associated_with	gene	0.60
IL6	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
FAS	interacts_with	gene	0.60
APH1B	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
NCSTN	interacts_with	gene	0.60
PSEN2	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
DYNEIN	interacts_with	gene	0.60
Dynein	interacts_with	protein	0.60
Kinesin	interacts_with	protein	0.60
BCHE	interacts_with	gene	0.60
CHRFAM7A	interacts_with	gene	0.60
CNTN1	interacts_with	gene	0.60
ESR1	interacts_with	gene	0.60
GABRB3	interacts_with	gene	0.60
SCARB2	interacts_with	gene	0.60
TFAM	interacts_with	gene	0.60
TREM2	interacts_with	gene	0.60
UCHL1	interacts_with	gene	0.60
APP	regulates	gene	0.60
LRP1	regulates	gene	0.60
RAGE	regulates	gene	0.60

Incoming (36)

Source	Relation	Type	Str
Hsv-1	binds	entity	0.95
HSV-1	binds	entity	0.90
HSV-1	binds_to	virus	0.90
Herpes simplex virus 1	binds_to	virus	0.80
NCSTN	interacts_with	gene	0.60
FAS	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
APH1B	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
PSEN2	interacts_with	gene	0.60
SGK1	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
DHCR24	interacts_with	gene	0.60
EIF2AK2	interacts_with	gene	0.60
IL1B	interacts_with	gene	0.60
DAPK1	interacts_with	gene	0.60
HMGCR	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
HSPG2	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
DYNEIN	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
PEN2	interacts_with	gene	0.60
MITOCHONDRIAL DNA	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
TFCP2	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

A2M

Understanding Entity Pages

Summary

Wiki Pages (15)

A2M Gene

PMN310 Anti-Amyloid for AD (NCT06750432)

PSEN2 — Presenilin 2

GABRB3 Gene

A2M Protein

PSEN2 Protein (Presenilin-2)

GABRB3

EIF2AK2 — Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2

Presenilin-2 (PSEN2)

Genes Overview

Proteins Overview

APH1B Gene - Anterior Pharynx Defective 1 Homolog B

NCSTN Protein