Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GLP1R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GLP1R is a concept in neurodegeneration research. Key relationships include: interacts with, inhibits, expressed in. Associated with ALS, Als, Hepatitis. Connected to 93 entities in the SciDEX knowledge graph.
| Name | GLP1R |
| Key Genes/Proteins | BDNF, GFRAL, GDNF, SREBF1 |
| Related Diseases | Als, Tumor, Hepatitis, ALS, Alzheimer |
Knowledge base pages for this entity
graph TD
GLP1R["GLP1R"]
GLP1R -->|"inhibits"| Als["Als"]
GLP1R -->|"interacts"| Tumor["Tumor"]
GLP1R -->|"interacts"| Hepatitis["Hepatitis"]
GLP1R -->|"inhibits"| ALS["ALS"]
GLP1R -->|"interacts"| BDNF["BDNF"]
GLP1R -->|"inhibits"| GFRAL["GFRAL"]
GLP1R -->|"inhibits"| GDNF["GDNF"]
GLP1R -->|"interacts"| SREBF1["SREBF1"]
GLP1R -->|"interacts"| SIRT1["SIRT1"]
h_ee1df336["h-ee1df336"] -->|"targets"| GLP1R
BDNF -->|"interacts"| GLP1R
PPARA["PPARA"] -->|"interacts"| GLP1R
ULK1["ULK1"] -->|"interacts"| GLP1R
STX17["STX17"] -->|"interacts"| GLP1R
SQSTM1["SQSTM1"] -->|"interacts"| GLP1R
NOS3["NOS3"] -->|"interacts"| GLP1R
STING1["STING1"] -->|"interacts"| GLP1R
GDNF -->|"inhibits"| GLP1R| Target | Relation | Type | Str |
|---|---|---|---|
| BDNF neurons | regulates | cell_type | 0.80 |
| NLY01 | activates | drug | 0.80 |
| Als | inhibits | disease | 0.65 |
| Tumor | interacts_with | disease | 0.65 |
| Hepatitis | interacts_with | disease | 0.65 |
| Als | activates | disease | 0.65 |
| ALS | inhibits | disease | 0.65 |
| Alzheimer | expressed_in | disease | 0.65 |
| neurodegeneration | associated_with | disease | 0.62 |
| BDNF | interacts_with | gene | 0.62 |
| GFRAL | inhibits | gene | 0.60 |
| GDNF | inhibits | gene | 0.60 |
| SREBF1 | interacts_with | gene | 0.60 |
| SIRT1 | interacts_with | gene | 0.60 |
| KDM6B | interacts_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| RPTOR | interacts_with | gene | 0.60 |
| PRKAA2 | interacts_with | gene | 0.60 |
| LAMP2 | interacts_with | gene | 0.60 |
| PLIN3 | interacts_with | gene | 0.60 |
| BECN1 | interacts_with | gene | 0.60 |
| GRK2 | interacts_with | gene | 0.60 |
| FOXO1 | interacts_with | gene | 0.60 |
| NR1H3 | interacts_with | gene | 0.60 |
| MAP3K5 | interacts_with | gene | 0.60 |
| SREBF2 | interacts_with | gene | 0.60 |
| NFE2L2 | interacts_with | gene | 0.60 |
| C1Q | interacts_with | gene | 0.60 |
| HTRA2 | interacts_with | gene | 0.60 |
| MTOR | interacts_with | gene | 0.60 |
| SIRT3 | interacts_with | gene | 0.60 |
| PLIN2 | interacts_with | gene | 0.60 |
| TP53 | interacts_with | gene | 0.60 |
| NOS3 | interacts_with | gene | 0.60 |
| neurodegeneration | implicated_in | disease | 0.60 |
| PPARA | interacts_with | gene | 0.60 |
| TFEB | interacts_with | gene | 0.60 |
| GRK2 | activates | entity | 0.60 |
| HTRA2 | activates | entity | 0.60 |
| KDM6B | activates | entity | 0.60 |
| LAMP2 | activates | entity | 0.60 |
| LC3 | activates | entity | 0.60 |
| MAP3K5 | activates | entity | 0.60 |
| MTOR | activates | entity | 0.60 |
| NFE2L2 | activates | entity | 0.60 |
| NOS3 | activates | entity | 0.60 |
| NR1H3 | activates | entity | 0.60 |
| P62 | activates | entity | 0.60 |
| PLIN2 | activates | entity | 0.60 |
| PLIN3 | activates | entity | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-ee1df336 | targets_gene | hypothesis | 0.90 |
| h-ee1df336 | targets | hypothesis | 0.80 |
| BDNF | interacts_with | gene | 0.62 |
| BDNF | inhibits | gene | 0.60 |
| PPARA | interacts_with | gene | 0.60 |
| ULK1 | interacts_with | gene | 0.60 |
| STX17 | interacts_with | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| NOS3 | interacts_with | gene | 0.60 |
| STING1 | interacts_with | gene | 0.60 |
| GDNF | inhibits | gene | 0.60 |
| GFRAL | inhibits | gene | 0.60 |
| FOXO1 | interacts_with | gene | 0.60 |
| TFEB | interacts_with | gene | 0.60 |
| MTOR | interacts_with | gene | 0.60 |
| P62 | interacts_with | gene | 0.60 |
| NR1H3 | interacts_with | gene | 0.60 |
| MAP3K5 | interacts_with | gene | 0.60 |
| LAMP2 | interacts_with | gene | 0.60 |
| BECN1 | interacts_with | gene | 0.60 |
| RPTOR | interacts_with | gene | 0.60 |
| HTRA2 | interacts_with | gene | 0.60 |
| PRKAA2 | interacts_with | gene | 0.60 |
| GRK2 | interacts_with | gene | 0.60 |
| KDM6B | interacts_with | gene | 0.60 |
| SIRT1 | interacts_with | gene | 0.60 |
| NFE2L2 | interacts_with | gene | 0.60 |
| TP53 | interacts_with | gene | 0.60 |
| SREBF2 | interacts_with | gene | 0.60 |
| PLIN2 | interacts_with | gene | 0.60 |
| PLIN3 | interacts_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| SIRT3 | interacts_with | gene | 0.60 |
| SREBF1 | interacts_with | gene | 0.60 |
| C1Q | interacts_with | gene | 0.60 |
| GDNF | expressed_in | entity | 0.60 |
| GFRAL | expressed_in | entity | 0.60 |
| BDNF | associated_with | entity | 0.60 |
| GFRAL | associated_with | entity | 0.60 |
| BECN1 | activates | entity | 0.60 |
| C1Q | activates | entity | 0.60 |
| FOXO1 | activates | entity | 0.60 |
| AQP4 | expressed_in | gene | 0.60 |
| BDNF | downstream_of | gene | 0.60 |
| BDNF | implicated_in | gene | 0.60 |
| BECN1 | regulates | gene | 0.60 |
| C1Q | regulates | gene | 0.60 |
| FOXO1 | regulates | gene | 0.60 |
| GFRAL | implicated_in | gene | 0.60 |
| GDNF | co_localizes_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||