protein

P2RX1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P2RX1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The P2X1 receptor (P2X1R) is a member of the P2X family of ATP-gated ion channels, encoded by the P2RX1 gene. It is one of the fastest desensitizing P2X receptors and is primarily expressed in smooth muscle, platelets, and certain neuronal populations.

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🔬 Protein Info

Gene Symbol	P2RX1PROTEIN
Protein Type	Channel
Function	is a member of the P2X family of ATP-gated ion channels, encoded by the P2RX1 gene.
Primary Expression	smooth muscle, platelets, and certain neuronal populations
Amino Acids	399 aa
GeneCards	P2RX1PROTEIN
Human Protein Atlas	P2RX1PROTEIN
N-terminal extracellular domain	ATP binding site with conserved motifs
Two transmembrane domains	TM1 and TM2 forming the pore
C-terminal intracellular domain	Short regulatory tail
Conserved cysteine residues	Form disulfide bonds for structural stability
Associated Diseases	Als, Inflammation
Interactions	adora2b, ADORA2B, ADRA2A, ALDH1A2, F3, GENES
KG Connections	81 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

P2X1 Receptor Protein

protein · 648 words

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Pathway Diagram

graph TD
    P2RX1PROTEIN["P2RX1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    P2RX1PROTEIN -->|"implicated_in"| neurodegeneration
    style P2RX1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning P2RX1PROTEIN in their description or question text

No additional research found