gene

adora2b

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about adora2b: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

0Hypotheses

0Analyses

42Outgoing

15Incoming

0Experiments

0Debates

No summary available yet. View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	ADORA2B
Chromosome	17p12
Protein Type	Receptor
Function	encodes a G protein-coupled receptor that plays important roles in modulating cellular responses to adenosine.
Primary Expression	astrocytes, microglia, neurons, and endothelial cells of the [
Molecular Weight	44 kDa
Pathways	PI3K, MAPK Pathway, NF-κB Pathway, NF-κB
UniProt ID	P29274
NCBI Gene ID	136
Ensembl ID	ENSG00000171490
OMIM	600446
GeneCards	ADORA2B
Human Protein Atlas	ADORA2B
Gαs-coupled	Stimulates adenylate cyclase, increasing cAMP levels
Low Affinity	Requires higher adenosine concentrations than A2A receptor (Kd ~10-20 μM vs ~0.5-5 μM for A2A)
Associated Diseases	Als, Inflammation, ALS, neurodegeneration
KG Connections	2 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: adora2b — AlphaFold P29274 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ADORA2B Gene

gene · 970 words

→

Pathway Diagram

graph TD
    ADORA2B["ADORA2B"]
    ADORA2B -->|"expressed in"| immune_cells["immune cells"]
    ADORA2B -->|"activates"| AMPK["AMPK"]
    ADORA2B -->|"binds"| netrin_1["netrin-1"]
    ADORA2B -->|"upregulates"| hypoxia["hypoxia"]
    ADORA2B -->|"contributes to"| immune_suppression["immune suppression"]
    ADORA2B -->|"downregulates"| mGluR5["mGluR5"]
    ADORA2B -->|"regulates"| inflammation["inflammation"]
    ADORA2B -->|"activates"| Covid["Covid"]
    P2RY1["P2RY1"] -->|"activates"| ADORA2B
    P2RX7["P2RX7"] -->|"activates"| ADORA2B
    P2RY12["P2RY12"] -->|"activates"| ADORA2B
    P2RX5["P2RX5"] -->|"activates"| ADORA2B
    GENES["GENES"] -->|"activates"| ADORA2B
    P2RX4["P2RX4"] -->|"activates"| ADORA2B
    PANX1["PANX1"] -->|"activates"| ADORA2B
    P2RX1["P2RX1"] -->|"activates"| ADORA2B

Outgoing (42)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ADORA2B	data_in	dataset_row	0.00
immune cells	expressed_in	cell_type	0.90
adenosinergic pathway	involved_in	pathway	0.90
Leukocyte	expressed_in	cell_type	0.85
hypoxia	upregulates	biological_process	0.80
immune suppression	contributes_to	biological_process	0.80
netrin-1	binds	protein	0.80
mGluR5	downregulates	receptor	0.80
AMPK	activates	protein	0.80
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Covid	activates	disease	0.65
Als	activates	disease	0.65
Inflammation	inhibits	disease	0.65
P2RY12	activates	gene	0.60
P2RX5	regulates	entity	0.60
P2RX7	regulates	entity	0.60
P2RY1	regulates	entity	0.60
P2RY12	regulates	entity	0.60
PANX1	regulates	entity	0.60
GENES	activates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
FN1	activates	gene	0.60
NAD	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
P2RX4	regulates	entity	0.60
P2RX1	activates	gene	0.60
P2RX4	activates	gene	0.60
P2RX7	activates	gene	0.60
CD38	associated_with	gene	0.60
P2RY1	activates	gene	0.60
P2RX5	activates	gene	0.60
PANX1	activates	gene	0.60
IL5	inhibits	gene	0.60
OCLN	activates	gene	0.60
P2RX1	regulates	entity	0.60
ATP	associated_with	gene	0.60
App	associated_with	protein	0.60
F3	activates	gene	0.60
Covid	activates	disease	0.50
GENE EXPRESSION	activates	concept	0.50

Incoming (15)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ADORA2B	data_in	dataset_row	0.00
Caffeine	inhibits	drug	0.95
CD38	associated_with	gene	0.60
ATP	associated_with	gene	0.60
P2RX1	activates	gene	0.60
GENES	activates	gene	0.60
NAD	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
AND	activates	gene	0.60
P2RY12	activates	gene	0.60
P2RX5	activates	gene	0.60
P2RX4	activates	gene	0.60
PANX1	activates	gene	0.60
P2RY1	activates	gene	0.60
P2RX7	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity