concept

PAQR4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PAQR4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

30Outgoing

3Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	PAQR4
Key Genes/Proteins	CERS2, CERS5
Related Diseases	Lipodystrophy, Hyperglycemia, Hyperinsulinemia, Partial Lipodystrophy, Hyperglycaemia

Pathway Diagram

graph TD
    PAQR4["PAQR4"]
    PAQR4 -->|"mediates"| Ceramide["Ceramide"]
    PAQR4 -->|"regulates"| Adipocyte_Function["Adipocyte Function"]
    PAQR4 -->|"regulates"| Metabolic_Health["Metabolic Health"]
    PAQR4 -->|"mediates"| CERS2["CERS2"]
    PAQR4 -->|"mediates"| CERS5["CERS5"]
    PAQR4 -->|"regulates"| Ceramide_Homeostasis["Ceramide Homeostasis"]
    PAQR4 -->|"mediates"| Ceramide_Levels["Ceramide Levels"]
    AGING["AGING"] -->|"regulates"| PAQR4
    CERS2 -->|"regulates"| PAQR4

Outgoing (30)

Target	Relation	Type	Str
CERS2	mediates	gene	0.95
CERS5	mediates	gene	0.95
Ceramide Homeostasis	regulates	process	0.95
CERS5	regulates	gene	0.95
Ceramide Levels	mediates	compound	0.94
Glucose Homoeostasis	regulates	process	0.90
Adipogenesis	suppresses	process	0.90
Adipocyte De-Differentiation	associated_with	process	0.90
Lipodystrophy	causes	disease	0.90
ceramide levels	regulates	compound	0.90
Hyperglycemia	causes	phenotype	0.85
Hyperinsulinemia	causes	phenotype	0.85
Lipodystrophy	contributes_to	disease	0.85
Partial Lipodystrophy	causes	disease	0.85
Hyperglycaemia	causes	phenotype	0.85
Adipose Tissue Remodelling	regulates	process	0.85
glucose homeostasis	regulates	process	0.85
Diet-Induced Obesity	associated_with	disease	0.80
Obesity	activates	disease	0.65
Longevity	regulates	disease	0.65
Aging	regulates	disease	0.65
Diabetes	regulates	disease	0.65
AGING	regulates	gene	0.60
AND	regulates	gene	0.60
CERS2	regulates	gene	0.60
Leptin	activates	protein	0.60
Insulin	activates	protein	0.60
Ras	activates	protein	0.60
Rb	regulates	protein	0.60
App	therapeutic_target	protein	0.60

Incoming (3)

Source	Relation	Type	Str
AGING	regulates	gene	0.60
CERS2	regulates	gene	0.60
CERS5	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found