Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Longevity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Longevity is a disease characterized by neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with Aging, Als, Alzheimer. Connected to 307 entities in the SciDEX knowledge graph.
| Associated Genes | CD38, NAMPT, DNA, AMPK, CERS2, SIRT1, AGING, MITOPHAGY |
| KG Connections | 408 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Longevity["Longevity"] -->|"associated"| Immune_Response["Immune Response"]
Longevity["Longevity"] -->|"associated"| Glycolysis["Glycolysis"]
Longevity["Longevity"] -->|"therapeutic target"| Pi3K["Pi3K"]
Longevity["Longevity"] -->|"therapeutic target"| Apoptosis["Apoptosis"]
Longevity["Longevity"] -->|"biomarker for"| Complement["Complement"]
Longevity["Longevity"] -->|"biomarker for"| Apoptosis_1["Apoptosis"]
Cellular_Maintenance["Cellular Maintenance"] -->|"contributes to"| Longevity["Longevity"]
Biomarkers_Of_Aging_Consortium["Biomarkers Of Aging Consortium"] -->|"involved in"| Longevity["Longevity"]
CERS2["CERS2"] -->|"regulates"| Longevity["Longevity"]
DES["DES"] -->|"therapeutic target"| Longevity["Longevity"]
style Longevity fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Senescence | inhibits | pathway | 0.80 |
| Alzheimer | activates | disease | 0.75 |
| Autophagy | associated_with | pathway | 0.70 |
| Autophagy | regulates | pathway | 0.70 |
| Proteasome | activates | pathway | 0.70 |
| Aging | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Cardiovascular | associated_with | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Anxiety | activates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| Immune Response | associated_with | pathway | 0.60 |
| Glycolysis | associated_with | pathway | 0.60 |
| Pi3K | therapeutic_target | pathway | 0.60 |
| Apoptosis | therapeutic_target | pathway | 0.60 |
| Complement | biomarker_for | pathway | 0.60 |
| Apoptosis | biomarker_for | pathway | 0.60 |
| Mtor | inhibits | pathway | 0.60 |
| Nf-Κb | inhibits | pathway | 0.60 |
| Cell Cycle | activates | pathway | 0.60 |
| Apoptosis | inhibits | pathway | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Insulin Signaling | activates | pathway | 0.60 |
| Senescence | activates | pathway | 0.60 |
| Angiogenesis | activates | pathway | 0.60 |
| Stem Cell | treats | pathway | 0.60 |
| Senescence | treats | pathway | 0.60 |
| Differentiation | contributes_to | pathway | 0.60 |
| Senescence | therapeutic_target | pathway | 0.60 |
| Epigenetic | regulates | pathway | 0.60 |
| Mtor | therapeutic_target | pathway | 0.60 |
| Proteasome | causes | pathway | 0.60 |
| Tgf-Beta | protects_against | pathway | 0.60 |
| Mitochondrial Function | causes | pathway | 0.60 |
| Metastasis | regulates | pathway | 0.60 |
| Mtor | regulates | pathway | 0.60 |
| Mitophagy | regulates | pathway | 0.60 |
| Mitochondrial Function | activates | pathway | 0.60 |
| Oxidative Phosphorylation | inhibits | pathway | 0.60 |
| Oxidative Stress | regulates | pathway | 0.60 |
| Lipid Metabolism | regulates | pathway | 0.60 |
| Mitochondrial Function | regulates | pathway | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| Circadian Rhythm | associated_with | pathway | 0.60 |
| Ubiquitin-Proteasome | activates | pathway | 0.60 |
| Nf-Κb | activates | pathway | 0.60 |
| Microrna | therapeutic_target | pathway | 0.60 |
| Rna Splicing | associated_with | pathway | 0.60 |
| Telomere | associated_with | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Als | associated_with | disease | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| SIRT1 | activates | gene | 1.00 |
| AGING | associated_with | gene | 1.00 |
| Aging | associated_with | disease | 1.00 |
| AGING | activates | gene | 1.00 |
| Aging | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| AGING | regulates | gene | 0.95 |
| AGING | therapeutic_target | gene | 0.95 |
| Ampk | mediates | pathway | 0.90 |
| Calorie Restriction | associated_with | process | 0.90 |
| Dietary Restriction | associated_with | process | 0.90 |
| GENES | regulates | gene | 0.85 |
| AUTOPHAGY | regulates | gene | 0.85 |
| NEURODEGENERATION | activates | gene | 0.85 |
| Cellular Maintenance | contributes_to | process | 0.85 |
| Biomarkers Of Aging Consortium | involved_in | process | 0.85 |
| CANCER | activates | gene | 0.85 |
| CANCER | associated_with | gene | 0.85 |
| ALZHEIMER | activates | gene | 0.85 |
| ALZHEIMER'S DISEASE | activates | gene | 0.85 |
| Lithocholic Acid | associated_with | compound | 0.85 |
| SIRT | regulates | protein | 0.85 |
| Intermittent Fasting | protects_against | drug | 0.85 |
| SIRT3 | regulates | protein | 0.80 |
| FOXO3A | associated_with | protein | 0.80 |
| Cancer | associated_with | disease | 0.75 |
| DNA | associated_with | gene | 0.75 |
| INFLAMMATION | inhibits | gene | 0.75 |
| CANCER | inhibits | gene | 0.75 |
| SIRT1 | associated_with | gene | 0.75 |
| MITOPHAGY | regulates | gene | 0.75 |
| CANCER | regulates | gene | 0.75 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.75 |
| MIRNAS | therapeutic_target | gene | 0.75 |
| APOPTOSIS | inhibits | gene | 0.75 |
| INFLAMMATION | associated_with | gene | 0.75 |
| GENES | associated_with | gene | 0.75 |
| GENES | activates | gene | 0.75 |
| Cancer | activates | disease | 0.75 |
| Aging | therapeutic_target | disease | 0.75 |
| Aging | regulates | disease | 0.75 |
| NAD | regulates | gene | 0.75 |
| AUTOPHAGY | associated_with | gene | 0.75 |
| ALZHEIMER | therapeutic_target | gene | 0.75 |
| INFLAMMATION | activates | gene | 0.75 |
| TAU | activates | gene | 0.75 |
| ANXIETY | activates | gene | 0.75 |
| AMYLOID | activates | gene | 0.75 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| FOXO3-Longevity Pathway Epigenetic Reprogramming | 0.386 | neurodegeneration | Epigenetic clocks and biological aging i |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Increased mitophagy protects cochlear hair cells from aminoglycoside-induced dam [PMID:35471096] | Zhang Y, Fang Q, Wang H, Qi J, Sun S, Li | Autophagy | 2023 | 1 |
| Fifteen-minute consultation: Therapeutic hypothermia for infants with hypoxic is [PMID:31292147] | Cawley P, Chakkarapani E | Arch Dis Child Educ Pract Ed | 2020 | 1 |
| Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve reg [PMID:30135423] | Sahoo PK, Lee SJ, Jaiswal PB, Alber S, K | Nat Commun | 2018 | 1 |
| EB1 and EB3 regulate microtubule minus end organization and Golgi morphology. [PMID:28814570] | Yang C, Wu J, de Heus C, Grigoriev I, Li | J Cell Biol | 2017 | 1 |
| c-Rel Regulates Inscuteable Gene Expression during Mouse Embryonic Stem Cell Dif [PMID:26694615] | Ishibashi R, Kozuki S, Kamakura S, Sumim | J Biol Chem | 2016 | 1 |
| DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperate [PMID:24652652] | Polato F, Rusconi P, Zangrossi S, Morell | J Natl Cancer Inst | 2014 | 1 |
| IRF4 addiction in multiple myeloma. [PMID:18568025] | Shaffer AL, Emre NC, Lamy L, Ngo VN, Wri | Nature | 2008 | 1 |
| Guishen-erxian decoction can improve ovarian function in rats with premature ova [PMID:40931880] | Zhong H, He Y, Wang W, Liu Y, Chen D et | Histol Histopathol | 2026 | 0 |
| Metabolic surgery mitigates early kidney injury in obese youth with diabetes by [PMID:41665972] | Naik AS, Alakwaa FM, Nair V, McCown PJ, | J Clin Invest | 2026 | 0 |
| FGF21-Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by [PMID:41860561] | Wu ZL, Ran R, Xie QQ, Zhang C, Chen YJ e | Aging Cell | 2026 | 0 |
| Kaempferol Mitigates Liver Injury Induced by Copper Toxicity Through the Activat [PMID:41891498] | Xu J, Wan W, Mu H, Gong S, Liu Y et al. | J Biochem Mol Toxicol | 2026 | 0 |
| IL-27-Ucp2-FoxO3 axis mediating the polarization of alternatively activated macr [PMID:41918304] | Ma Y, Gan S, Zheng Y, Kang X, Zhu S | Korean J Pain | 2026 | 0 |
| [The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579] | Wu K, Wang N, Zhao D, Wei W, Zhang W et | Zhejiang Da Xue Xue Bao Yi Xue | 2026 | 0 |
| Genome-wide association study and pathway analysis of healthy aging in Super Sen [PMID:41964836] | Hoque R, Leach S, Brooks-Wilson A | Geroscience | 2026 | 0 |
| Dnmt3a-mediated hypermethylation of FoxO3 promotes redox imbalance during osteoc [PMID:40106360] | Zhang W, Li W, Du J, Yang C, Yu L, Yang | Proceedings of the National Ac | 2025 | 0 |
| Mitochondrial dysfunction and aging: multidimensional mechanisms and therapeutic [PMID:40634825] | Wei P, Zhang X, Yan C, Sun S, Chen Z, Li | Biogerontology | 2025 | 0 |
| The multifaceted impact of physical exercise on FoxO signaling pathways. [PMID:40861274] | Liu W, Meng P, Li Z, Shen Y, Meng X, Jin | Frontiers in cell and developm | 2025 | 0 |
| Assessment of the Spatial Distribution of Moisture Content in Granular Material [PMID:31234567] | ["Porzuczek J"] | Sensors (Basel, Switzerland) | 2024 | 0 |
| Banxia Xiexin Decoction Prevents HT22 Cells from High Glucose-induced Neurotoxic [PMID:37608672] | ["Shi Y", "Sheng P", "Guo M", "Chen K", | Current computer-aided drug de | 2024 | 0 |
| Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3. [PMID:36252111] | Zhu D, Liu S, Huang K, Wang Z, Hu S, Li | Circulation research | 2022 | 0 |