Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PARK16: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PARK16 is a Parkinson's disease risk locus containing multiple genes including RAB7L1, associated with lysosomal trafficking, autophagy, and dopaminergic neuron survival.
| Gene Symbol | RAB7L1 (primary gene at locus) |
| Full Name | RAB7-like 1 |
| Aliases | PARK16 |
| Chromosome | 1q32 |
| Amino Acids | 220 aa |
| Pathways | Role of RAB7L1 |
| UniProt ID | Q96NA5 |
| NCBI Gene ID | 493856 |
| Ensembl ID | ENSG00000109189 |
| Alternative Names | RAB7B, Rab7-like protein 1 |
| Gene | Function |
| RAB7L1 | Rab GTPase, vesicular trafficking |
| SLC45A3 | Solute carrier, prostate-specific |
| NUCKS1 | Nuclear casein kinase substrate |
| PM20D1 | Peptidase/amino acid metabolism |
| Associated Diseases | Parkinson, Parkinson's disease |
| Interactions | RAB10, AND, PARKINSON'S DISEASE, Actin, LRRK2 |
| KG Connections | 20 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PARK16["<b>PARK16</b>"]
Parkinson{"Parkinson"}
PARK16 -->|"associated with"| Parkinson
RAB10["RAB10"]
PARK16 -->|"activates"| RAB10
RAB29["RAB29"]
PARK16 -->|"associated with"| RAB29
LRRK2["LRRK2"]
PARK16 -->|"associated with"| LRRK2
neurodegeneration["neurodegeneration"]
PARK16 -->|"implicated in"| neurodegeneration
RAB29 -->|"associated with"| PARK16
LRRK2 -->|"associated with"| PARK16
RAB10 -->|"activates"| PARK16
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"activates"| PARK16
PARKINSON["PARKINSON"]
PARKINSON -->|"associated with"| PARK16
AND["AND"]
AND -->|"activates"| PARK16
style PARK16 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson | associated_with | disease | 0.65 |
| RAB10 | activates | gene | 0.60 |
| RAB29 | associated_with | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
| AND | activates | gene | 0.60 |
| PARKINSON'S DISEASE | activates | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| Actin | activates | protein | 0.60 |
| Parkinson's disease | associated_with | disease | 0.60 |
| PARKINSON | expressed_in | gene | 0.50 |
| PARKINSON'S | expressed_in | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||